Abstract:
:Bilateral lesion of the nucleus basalis with ibotenic acid infusions in young and aged rats results in the degeneration of cholinergic neurons which innervate the cortex. As expected, high-affinity uptake of choline was decreased in the frontal cortex subsequent to the lesion. Twenty one days after surgery there was a significantly decrease of the transport rate of GABA, glutamate and glycine in the frontal cortex of young rats, but those activities showed a recovery six months after lesion. On the contrary, 12-month old rats lesioned with the same experimental protocol showed no recovery of the transport rates in the frontal cortex. Uptake of choline, GABA, glutamate and glycine has also been studied in other areas of the brain, namely, hippocampus, olfactory bulb and cerebellum. The present results suggest that lesioning the nucleus basalis of rats led to a more effective and permanent impairment of some biochemical functions of the brain, when compared to young lesioned animals, and also suggest a functional relationship between the nucleus basalis and other areas of the brain.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Gomeza J,Aragón C,Giménez Cdoi
10.1007/BF00974576keywords:
subject
Has Abstractpub_date
1992-04-01 00:00:00pages
345-50issue
4eissn
0364-3190issn
1573-6903journal_volume
17pub_type
杂志文章abstract::The conversion of phosphoethanolamine to phosphocholine requires 3 separate N-methyltransferases. We had previously purified the enzyme catalyzing the last methylation, phosphodimethylethanolamine N-methyltransferase. We have successfully purified the enzyme catalyzing the initial methylation of phosphoethanolamine. A...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00995388
更新日期:1995-10-01 00:00:00
abstract::Parecoxib is a recently described novel COX-2 inhibitor whose functional significance and neuroprotective mechanisms remain elusive. Therefore, in this study, we aimed to investigate whether delayed administration of parecoxib inhibited mitochondria-mediated neuronal apoptosis induced by ischemic reperfusion injury vi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0615-y
更新日期:2012-02-01 00:00:00
abstract::Calcium-naive synaptosomes were used to assess the effects of divalent cations on [3H]acetylcholine release from rat hippocampal homogenates. Following equilibration with calcium-free buffer (containing 10 microM EGTA), calcium reversibly increased [3H]acetylcholine efflux (up to five-fold) while causing no measurable...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966598
更新日期:1991-10-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disease, with genetics and environment contributing to the disease onset. The limited pathological cognize of the disease restrained the approaches to improve the clinical treatment. Recently, studies showed that endoplasmic reticulum (ER) stress played an important role...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1922-0
更新日期:2016-08-01 00:00:00
abstract::Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964224
更新日期:1980-04-01 00:00:00
abstract::Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02778-5
更新日期:2020-03-01 00:00:00
abstract::Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965830
更新日期:1991-01-01 00:00:00
abstract::Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964414
更新日期:1981-10-01 00:00:00
abstract::The effects of neuroleptic treatments on dopamine transporters and on dopamine receptors was investigated in the forebrain of adult rats treated for 21 days with either haloperidol, clozapine or saline. The dopamine D1 receptors, labeled with [3H]SCH23390, increased in nucleus accumbens, latero-dorsal rostral neostria...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022405621365
更新日期:1998-01-01 00:00:00
abstract::Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-017-2430-6
更新日期:2018-02-01 00:00:00
abstract::Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007632326953
更新日期:2000-11-01 00:00:00
abstract::The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973322
更新日期:1988-02-01 00:00:00
abstract::Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Here, the effect of proteasome inhibition on the morphology of cultured rat cortical astrocytes was investigated. Increasing evidence suggests that the function of astrocytes is related close...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9830-6
更新日期:2009-05-01 00:00:00
abstract::Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03017-y
更新日期:2020-07-01 00:00:00
abstract::Plasmalogens are ether-linked phospholipids that are abundant in nervous tissues. Their biological role is unclear, but may involve membrane structure/function and antioxidant activities. This study further investigates a recent report that chronic administration of myo-inositol in rats increased brain phosphatidyleth...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000018859.23881.f9
更新日期:2004-04-01 00:00:00
abstract::It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activity of neurons, but the detailed mechanism is still an open question. In this study, ES was used to stimulate c...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1197-7
更新日期:2014-01-01 00:00:00
abstract::An analytical method for the determination of saturated very long chain (VLC) fatty acids in the serum has been devised. Free fatty acids obtained after hydrolysis of total lipid extracts were converted into p-bromophenacyl esters. The derivatives were purified in two sequential steps by clean-up on C18 reversed-phase...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968082
更新日期:1984-12-01 00:00:00
abstract::Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963809
更新日期:1979-06-01 00:00:00
abstract::The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02833-1
更新日期:2019-08-01 00:00:00
abstract::Analysis in mouse brain slices of the uptake of acetyl-L-[N-methyl-14C]carnitine with time showed it to be concentrative, and kinetic analysis gave a Km of 1.92 mM and a Vmax of 1.96 mumol/min per ml, indicating the presence of a low-affinity carrier system. The uptake was energy-requiring and sodium-dependent, being ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964865
更新日期:1989-05-01 00:00:00
abstract::Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021670607647
更新日期:2002-12-01 00:00:00
abstract::We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026670620633
更新日期:2000-12-01 00:00:00
abstract::Menadione (2-methyl-1,4-naphthoquinone) is a synthetic derivative of vitamin K that allows rapid redox cycling in cells and thereby generates reactive oxygen species (ROS). To test for the consequences of a treatment of brain astrocytes with menadione, we incubated primary astrocyte cultures with this compound. Incuba...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-019-02760-1
更新日期:2019-05-01 00:00:00
abstract::The study examined (a) whether there is sex difference in spinal cord and plasma oxidative stress profiles in Dark Agouti rats immunised for experimental autoimmune encephalomyelitis (EAE), the principal experimental model of multiple sclerosis, and (b) whether there is correlation between the oxidative stress in spin...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2094-7
更新日期:2017-02-01 00:00:00
abstract::The antibodies against omega-conotoxin GVIA (omega-CTX GVIA; N-type voltage-dependent calcium channel [VDCC] blocker) and B1Nt (N-terminal segment [residues 1-13] of BI alpha1 subunits of VDCCs) were prepared, and the selectivity for each antigen omega-CTX GVIA and B1Nt was investigated. For the antigen selectivity of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1023208103438
更新日期:2003-06-01 00:00:00
abstract::The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applicat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9966-z
更新日期:2009-11-01 00:00:00
abstract::Ethyl pyruvate (EP) has recently been reported to afford protection against neurodegenerative disorders. However, the mechanism underlying EP-mediated neuroprotection remains to be elucidated. Because peroxynitrite has been extensively implicated in the pathogenesis of various forms of neurodegenerative disorders via ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-0059-9
更新日期:2010-02-01 00:00:00
abstract::Brain noradrenergic system has been implicated in early-life stress effects on adult physiology and behavior; however, the mechanisms for this relationship are not clear. Here we tested the hypothesis that stress hormones, glucocorticoids, may affect noradrenergic system activity by modulating gene expression and func...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0676-y
更新日期:2012-04-01 00:00:00
abstract::The major breakthrough discovery of enkephalins as endogenous opiates led our attempts to determine their inactivation mechanisms. Because the NH2-terminal tyrosine is absolutely necessary for the neuropeptides to exert analgesic effects, and aminopeptidase activities are extraordinarily high in the brain, a specific ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-007-9356-3
更新日期:2007-12-01 00:00:00
abstract::The finding that ketamine, an anaesthetic, can elicit a rapid antidepressant effect at low doses that lasts for weeks in patients with depression is arguably a major achievement in psychiatry in the last decades. However, the mechanisms of action are unclear. The glutamatergic hypothesis of ketamine action posits that...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02744-1
更新日期:2020-01-01 00:00:00