Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat.

abstract：:Bovine brain synaptic membranes which were frozen and then extensively washed showed low affinity [3H]muscimol binding. These membranes contained GABA and calmodulin, apparently tightly bound within the membrane fraction. Membranes which were additionally treated with the detergent Triton X-100 showed high affinity [3...

journal_title：Neurochemical research

authors： O'Neill C,Williams DC

更新日期：1988-09-01 00:00:00

abstract：:Deciphering what governs inflammation and its effects on tissues is vital for understanding many pathologies. The recent discovery that glycogen synthase kinase-3 (GSK3) promotes inflammation reveals a new component of its well-documented actions in several prevalent diseases which involve inflammation, including mood...

journal_title：Neurochemical research

authors： Jope RS,Yuskaitis CJ,Beurel E

更新日期：2007-04-01 00:00:00

abstract：:Specific [3H]MK801 binding to rat brain NMDA receptors after the administration of the convulsant drug 3-mercaptopropionic acid (MP) and the adenosine analogue cyclopentyladenosine (CPA) was studied by means of a quantitative autoradiographic method. MP administration (150 mg/kg, i.p.) caused significant decreases in ...

journal_title：Neurochemical research

authors： Giraldez L,Girardi E

更新日期：1998-10-01 00:00:00

abstract：:One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melaton...

journal_title：Neurochemical research

authors： Li X,Zhang M,Tang W

更新日期：2013-03-01 00:00:00

abstract：:Lipid peroxides, quantitated as lipid conjugated dienes, and (Na+, K+)-ATPase activity were assayed concurrently in brains of control rats and in three groups subjected to 30 min of reversible forebrain ischemia followed by 0, 1, and 4 hr of recirculation. Multiple small samples were taken from lateral, dorsolateral a...

journal_title：Neurochemical research

authors： Goldberg WJ,Watson BD,Busto R,Kurchner H,Santiso M,Ginsberg MD

更新日期：1984-12-01 00:00:00

abstract：:Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervo...

journal_title：Neurochemical research

authors： Nieoczym D,Socała K,Wlaź P

更新日期：2018-05-01 00:00:00

abstract：:The experiments reported in this paper address the hypothesis that [3H]leucine enkephalin labels both mu and delta receptors. As reported by other workers, this peptide dissociates from rat brain membranes in a biphasic manner. This is consistent with a two site binding model which hypothesizes that the peptide labels...

journal_title：Neurochemical research

authors： Rothman RB,Westfall TC

更新日期：1983-02-01 00:00:00

abstract：:Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei iso...

journal_title：Neurochemical research

authors： Greenwood PD,Brown IR

更新日期：1982-08-01 00:00:00

abstract：:In this study, we investigated if subunit displacement and/or alterations in proteasome biosynthesis are responsible for the changes in the levels of constitutive proteasomes (c-20S), immunoproteasomes (i-20S) and the activators PA28 and PA700 in neurons and astrocytes cultured with a cytokine mixture (IFN-γ/TNF-α/IL-...

journal_title：Neurochemical research

authors： Shanley KL,Hu CL,Bizzozero OA

更新日期：2020-04-01 00:00:00

abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...

journal_title：Neurochemical research

authors： Meyer EM,Otero DH

更新日期：1989-02-01 00:00:00

abstract：:Ciliary ganglion neurons and nonneurons can be separated from each other, based on the greater adhesivity of the nonneurons to untreated tissue culture plastic in the presence of serum. When the separation was carried out in the presence of Serum Plus (a commercially available supplemented serum), two populations of n...

journal_title：Neurochemical research

authors： Needels DL,Nieto-Sampedro M,Cotman CW

更新日期：1987-10-01 00:00:00

abstract：:To assess RNAi mediated inhibition of the expression of wt-DYT1 on H(2)O(2)-induced toxicity in NIH 3T3 cells and primary cortical neurons. To detect the function of wild-type Torsin A and the effect of SiRNA on the wt-DYT1 gene. The shRNA expression vector was constructed by ligating annealed complementary shRNA olig...

journal_title：Neurochemical research

authors： Chen XP,Hu XH,Wu SH,Zhang YW,Xiao B,Shang HF

更新日期：2010-08-01 00:00:00

abstract：:Previous studies have shown that hypoxia induces nitric oxide synthase-mediated generation of nitric oxide free radicals leading to peroxynitrite production. The present study tests the hypothesis that hypoxia results in NO-mediated modification of Na+, K+-ATPase in the fetal brain. Studies were conducted in guinea pi...

journal_title：Neurochemical research

authors： Qayyum I,Zubrow AB,Ashraf QM,Kubin J,Delivoria-Papadopoulos M,Mishra OP

更新日期：2001-10-01 00:00:00

abstract：:The action of electroacupuncture (EA) may be similar to analgesia by electrode stimulation or transcutaneous nerve stimulation. Since EA may directly stimulate nerve activity or indirectly enhance the release of opiate peptides and other neurotransmitter substances, we have used (Na+ + K+)-ATPase as a model to study t...

journal_title：Neurochemical research

authors： Lee DZ,Sun AY

更新日期：1984-05-01 00:00:00

abstract：:(4S)-4-Amino-5,6-heptadienoic acid [S)-gamma-allenyl-GABA; MDL 72483) is a potent inactivator of brain GABA-T in mice; (ED50 (i.p.) = 60 mg.kg-1; ED50 (oral) = 70 mg.kg-1). Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concent...

journal_title：Neurochemical research

authors： Sarhan S,Casara P,Knödgen B,Seiler N

更新日期：1991-03-01 00:00:00

abstract：:The immediate and long-term effects of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on rat striatal serotonergic neurons were examined after its intracerebroventricular administration using in vivo voltammetry. Extracellular concentration of 5-hydroxyindoles increased immediately following i...

journal_title：Neurochemical research

authors： Nakazato T,Akiyama A

更新日期：1998-01-01 00:00:00

abstract：:Brain noradrenergic system has been implicated in early-life stress effects on adult physiology and behavior; however, the mechanisms for this relationship are not clear. Here we tested the hypothesis that stress hormones, glucocorticoids, may affect noradrenergic system activity by modulating gene expression and func...

journal_title：Neurochemical research

authors： Kalinina TS,Shishkina GT,Dygalo NN

更新日期：2012-04-01 00:00:00

abstract：:In vitro aggregation and fibrillization of synthetic amyloid beta-protein Abeta 1-40 was assessed in the conditioned media from rhabdomyosarcoma (CRL 1598, HTB 82, HTB 153, CCL 136), adenocarcinoma (CCL 218), neuroblastoma (SY5Y), and COS cells cultured in the absence and presence of 10% heat-inactivated fetal bovine ...

journal_title：Neurochemical research

authors： Chauhan A,Chauhan VP,Rubenstein R,Wegiel J,Wisniewski HM

更新日期：1997-02-01 00:00:00

abstract：:The concentration of vitamin E (alpha-tocopherol) was measured in samples of cortex from patients with Alzheimer's disease (AD), fetuses with Down's syndrome (DS), and also in a group of centenarians. The mean tocopherol concentrations in the two patient groups did not differ significantly from appropriate controls. W...

journal_title：Neurochemical research

authors： Metcalfe T,Bowen DM,Muller DP

更新日期：1989-12-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...

journal_title：Neurochemical research

authors： Yamada D,Fujikawa K,Kawabe K,Furuta T,Nakada M,Takarada T

更新日期：2018-11-01 00:00:00

abstract：:There is ample evidence stating Polychlorinated biphenyls (PCBs) as neurotoxins. In the current study, we have analyzed the behavioural impact of PCBs exposure in adult rats and assessed the simultaneous effect of antioxidant melatonin against the PCBs action. The rats were grouped into four and treated intraperitonea...

journal_title：Neurochemical research

authors： Bavithra S,Selvakumar K,Sundareswaran L,Arunakaran J

更新日期：2017-02-01 00:00:00

abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...

journal_title：Neurochemical research

authors： Jiang B,Song L,Huang C,Zhang W

更新日期：2016-05-01 00:00:00

abstract：:This review presents data on metabotropic uridine nucleotide receptor subtypes (P2UR) activated by UTP, sometimes also by UDP and/or ATP. Some chemical details of receptor subtypes and ligand interactions are described. Ligand-activated P2UR subtypes may couple to different second messengers, yet little is known about...

journal_title：Neurochemical research

authors： Heilbronn E,Knoblauch BH,Müller CE

更新日期：1997-08-01 00:00:00

abstract：:Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...

journal_title：Neurochemical research

authors： Gong SJ,Chen LY,Zhang M,Gong JX,Ma YX,Zhang JM,Wang YJ,Hu YY,Sun XC,Li WB,Zhang Y

更新日期：2012-03-01 00:00:00

abstract：:Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine ...

journal_title：Neurochemical research

authors： Agostinho FR,Jornada LK,Schröder N,Roesler R,Dal-Pizzol F,Quevedo J

更新日期：2007-08-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood-brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a sub...

journal_title：Neurochemical research

authors： Yu Y,Fang H,Qiu Z,Xia Z,Zhou B

更新日期：2020-02-01 00:00:00

abstract：:When excised goldfish spinal cord is kept in physiological saline at room temperature, the myelin multilayers swell. As studied by X-ray diffraction, the original repeating distance of 150 A (AS myelin) swells to 177 A (AL myelin); no intermediate distances are seen. At least 70% of the myelin can undergo this gradual...

journal_title：Neurochemical research

authors： Blaurock AE,Yale JL,Roots BI

更新日期：1986-08-01 00:00:00

abstract：:Endogenous and xenobiotic sulphur-containing convulsant and non-convulsant compounds containing structural moieties of, or bearing a structural resemblance to, GABA and homocysteine were tested in binding studies for their potency in displacing the GABA-mimetic [3H]muscimol from specific, high-affinity sites (Kd = 3.6...

journal_title：Neurochemical research

authors： Egbuta JO,Griffiths R

更新日期：1987-07-01 00:00:00

abstract：:Exposure chronically to n-hexane produces peripheral-central axonopathy mediated by 2,5-hexanedione (HD). Previous studies have demonstrated decreases in neurofilament (NF) contents of peripheral and central nervous regions from rats intoxicated with HD, and recent analysis has demonstrated that axonal atrophy, instea...

journal_title：Neurochemical research

authors： Zhang T,Zhao X,Zhu Z,Yu L,Han X,Zhang C,Xie K

更新日期：2005-02-01 00:00:00

abstract：:CNTF (ciliary neurotrophic factor) has been suggested to be an important survival factor for oligodendrocytes; however, this effect is inconsistently obtained and myelination appears normal in CNTF null animals. On the other hand, CNTF stimulates astrocytes to produce growth and trophic factors. Therefore, we tested t...

journal_title：Neurochemical research

authors： Albrecht PJ,Enterline JC,Cromer J,Levison SW

更新日期：2007-02-01 00:00:00