Ca-controlled, reversible structural transition in myelin.

abstract：:Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...

journal_title：Neurochemical research

authors： Ma Y,Sun S,Zhang J,Chen Z,Guo F,Du Y,Zhang J

更新日期：2016-04-01 00:00:00

abstract：:The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decr...

journal_title：Neurochemical research

authors： Glaser J,Russell VA,de Villiers AS,Searson JA,Taljaard JJ

更新日期：1990-10-01 00:00:00

abstract：:The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...

journal_title：Neurochemical research

authors： Alshuaib WB,Mathew MV

更新日期：2005-09-01 00:00:00

abstract：:Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-d...

journal_title：Neurochemical research

authors： Gerstner JR,Landry CF

更新日期：2007-02-01 00:00:00

abstract：:Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...

journal_title：Neurochemical research

authors： Ramsohoye PV,Fritz IB

更新日期：1998-12-01 00:00:00

abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...

journal_title：Neurochemical research

authors： Jeong JI,Lee YW,Kim YK

更新日期：2003-08-01 00:00:00

abstract：:Deposition of amyloid beta peptide in human brain in the form of senile plaques is a neuropathological hallmark of Alzheimer's disease (AD). Levels of a phospholipid breakdown product, glycerophosphocholine (GPC), also increase in AD brain. The effect of GPC on amyloid beta(1-40) peptide (Abeta) aggregation in PBS buf...

journal_title：Neurochemical research

authors： Mandal PK,McClure RJ,Pettegrew JW

更新日期：2004-12-01 00:00:00

abstract：:The significant increase of free calcium concentration ([Ca2+]i) was found in rat cerebral cortex synaptosomes and hippocampal crude synaptosomal fraction after their exposure to glutamate. But no change of [Ca2+]i was revealed in cerebellar synaptosomes, the slight increase of [Ca2+]i in striatal synaptosomes was not...

journal_title：Neurochemical research

authors： Avrova NF,Shestak KI,Zakharova IO,Sokolova TV,Leont'ev VG

更新日期：1999-09-01 00:00:00

abstract：:The release of the inhibitory neurotransmitter GABA is generally enhanced under potentially cell-damaging conditions. The properties and regulation of preloaded [3H]GABA release from mouse hippocampal slices were now studied in free radical-containing medium in a superfusion system. Free radical production was induced...

journal_title：Neurochemical research

authors： Saransaari P,Oja SS

更新日期：2008-03-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid an...

journal_title：Neurochemical research

authors： Roscetti G,Possenti R,Bassano E,Roda LG

更新日期：1985-10-01 00:00:00

abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...

journal_title：Neurochemical research

authors： Li J,Yu T,Shi F,Zhang Y,Duan Z,Fu B,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:Zinc (Zn2+) was shown to invariably inhibit muscimol-stimulated 36Cl- uptake by synaptoneurosomes in the cerebral cortex, hippocampus and cerebellum. The Zn2+ sensitivity of the GABAA receptor-gated 36Cl- uptake in the cerebral cortex was comparable to that in the hippocampus, whereas the uptake in the cerebellum was ...

journal_title：Neurochemical research

authors： Ito Y,Segawa K,Kobayashi M,Fukuda H

更新日期：1996-08-01 00:00:00

abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...

journal_title：Neurochemical research

authors： Jiang F,Yin H,Qin X

更新日期：2012-09-01 00:00:00

abstract：:We investigated the effects of H(2)O(2)-induced oxidative stress on the delayed-rectifier current (IK(DR)), neuronal physiological and morphological properties. Measurements were obtained from hippocampal CA1 neurons in control solution and from the same neurons after exposure to oxidative stress (short- and long-term...

journal_title：Neurochemical research

authors： Hasan SM,Joe M,Alshuaib WB

更新日期：2007-07-01 00:00:00

abstract：:Donepezil is a selective inhibitor of acetylcholinesterase (AChE) clinically used for treating Alzheimer's disease. Cholinergic effects after short-term exposure of donepezil (up to 12 h) have been extensively studied in rats, but few have addressed the potential long-term effects. After 14 days administration (1x3 mg...

journal_title：Neurochemical research

authors： Haug KH,Bogen IL,Osmundsen H,Walaas I,Fonnum F

更新日期：2005-12-01 00:00:00

abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...

journal_title：Neurochemical research

authors： Olianas MC,Onali P

更新日期：1990-11-01 00:00:00

abstract：:(E)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeine (HOEC), a naturally caffeic ester isolated from Incarvillea mairei, has been reported to possess anti-inflammatory activity by targeting 5-lipoxygenase. However, its other potential activities have yet to be explored. In this study, we measured antioxidant activity of ...

journal_title：Neurochemical research

authors： Chen B,Yue R,Yang Y,Zeng H,Chang W,Gao N,Yuan X,Zhang W,Shan L

更新日期：2015-03-01 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA) and L-glutamate activate membrane receptors that produce substantial permeation of Na+, K+ and Ca2+ through the neuronal membrane. These ionic fluxes are intimately linked to processes that regulate neuronal survival, growth and differentiation. Intracellular free Ca2+ concentrations are th...

journal_title：Neurochemical research

authors： Michaelis EK,Michaelis ML

更新日期：1992-01-01 00:00:00

abstract：:Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...

journal_title：Neurochemical research

authors： Ma J,Liu J,Yu H,Chen Y,Wang Q,Xiang L

更新日期：2016-05-01 00:00:00

abstract：:Phosphate activated glutaminase (PAG) was assayed in whole homogenate and synaptosomes of cerebral cortex from normal or fasted for 120 h rats. The specific activity (s.a.) of PAG was found diminished by 25% in the whole homogenate from the fasted animals compared to the normal. On the contrary, fasting did not affect...

journal_title：Neurochemical research

authors： Lellos V,Tselentis V,Galanopoulos E,Philippidis H,Palaiologos G

更新日期：1991-01-01 00:00:00

abstract：:The calcium-activated phosphodiesteratic hydrolysis of 32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasi...

journal_title：Neurochemical research

authors： Van Rooijen LA,Agranoff BW

更新日期：1985-08-01 00:00:00

abstract：:T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...

journal_title：Neurochemical research

authors： Iwasaki Y,Ikeda K,Ichikawa Y,Igarashi O,Kinoshita M,Marubuchi S,Ono S

更新日期：2002-03-01 00:00:00

abstract：:We have previously shown that extracellular ATP caused cell death in PC12 cells through activation of its receptors. Oxidative stress has been implicated as a mechanism of cell death caused by extracellular ATP. In the present study we examined the possible signal transduction cascades leading to cell death by extrace...

journal_title：Neurochemical research

authors： Chen Y,Sun AY

更新日期：1998-04-01 00:00:00

abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...

journal_title：Neurochemical research

authors： Chaitanya GV,Babu PP

更新日期：2008-11-01 00:00:00

abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...

journal_title：Neurochemical research

authors： Tanaka K,Asanuma M,Ogawa N

更新日期：2004-08-01 00:00:00

abstract：:We have developed a coupled Xenopus oocyte expression system for evaluating the functional effects of mutations in known or suspected adhesion molecules, which allows for a very rapid assessment of intercellular adhesion. As a model protein, we first used Protein zero (Po), an adhesion molecule that mediates self-adhe...

journal_title：Neurochemical research

authors： Yoshida M,Colma DR

更新日期：2001-06-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a promising biological marker and prognostic indicator in many neurological diseases. Although VEGF concentrations in plasma and cerebrospinal fluid (CSF) are increasingly reported, CSF-VEGF stability pre- and during-assay procedures is seldom evaluated. In the current stud...

journal_title：Neurochemical research

authors： Yang J,Dombrowski SM,Deshpande A,Krajcir N,El-Khoury S,Krishnan C,Luciano MG

更新日期：2011-11-01 00:00:00

abstract：:Systemic inflammation is present in obesity and emerging evidence, primarily from studies using male rodents fed high-fat diets, suggests neuroimmune signaling also is involved. We investigated early changes in neuroimmune signaling during the weight gain that follows ovariectomy in rats. Ovariectomized (OVX) rats wer...

journal_title：Neurochemical research

authors： Curtis KS,McCracken K,Espinosa E,Ong J,Buck DJ,Davis RL

更新日期：2018-09-01 00:00:00

abstract：:The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the phar...

journal_title：Neurochemical research

authors： Roques BP,Noble F

更新日期：1996-11-01 00:00:00