Abstract：
:The calcium-activated phosphodiesteratic hydrolysis of 32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasing concentrations of Ca2+, indicating that the aminoglycosides exert their effect by displacing Ca2+ from lipid.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Van Rooijen LA,Agranoff BWdoi
10.1007/BF00965878subject
Has Abstractpub_date
1985-08-01 00:00:00pages
1019-24issue
8eissn
0364-3190issn
1573-6903journal_volume
10pub_type
杂志文章abstract：:Harpagophytum procumbens, popularly known as devil's claw, is a plant commonly used in the treatment of diseases of inflammatory origin. The anti-inflammatory effects of H. procumbens have been studied; however, the mechanism of action is not elucidated. It is known that excess of reactive oxygen and nitrogen species ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1133-x
更新日期：2013-11-01 00:00:00
abstract：:The effect of the calcium channel blocker (KB-2796) on metabolic and functional recovery in rabbit spinal cord after 20, 30, and 40 min ischemia and 4 days of recovery was investigated. The drug was given intraperitoneally in three different doses, 10, 20, or 50 mg/kg pre- or post-ischemia of 20, 30, or 40 min duratio...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968997
更新日期：1994-12-01 00:00:00
abstract：UNLABELLED:Depressive disorder is a multifactorial diseases, that one of the typical feature are cognitive impairments. The aim of this study was to determine the total antioxidant status (TAS) in patients with recurrent depressive disorder (rDD) and to define relationship between plasma levels of TAS and the cognitive...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0788-z
更新日期：2012-08-01 00:00:00
abstract：:The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2544-5
更新日期：2018-06-01 00:00:00
abstract：:Parkinson's disease (PD) is a common progressive neurodegenerative disorder, for which at present no causal treatment is available. On the understanding that the causes of PD are mainly oxidative stress and mitochondrial dysfunction, antioxidants and other drugs are expected to be used. In the present study, we demons...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0046-1
更新日期：2010-02-01 00:00:00
abstract：:The conversion of phosphoethanolamine to phosphocholine requires 3 separate N-methyltransferases. We had previously purified the enzyme catalyzing the last methylation, phosphodimethylethanolamine N-methyltransferase. We have successfully purified the enzyme catalyzing the initial methylation of phosphoethanolamine. A...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995388
更新日期：1995-10-01 00:00:00
abstract：:Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9608-x
更新日期：2008-09-01 00:00:00
abstract：:Mevalonate phosphorylation was studied in neonatal chick brain. Formation of phosphorylated derivatives of mevalonic acid increased with the pH in the range assays (5.5-9.5). Phosphomevalonate kinase was completely inactivated after treatment at 50 degree C for 5-10 min, whereas mevalonate kinase was found to retain i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965047
更新日期：1981-08-01 00:00:00
abstract：:It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1400-5
更新日期：2014-11-01 00:00:00
abstract：:The present work describes the kinetics of enkephalin hydrolysis by plasma enzymes and the fragmentation pattern of both the parent peptide and of the first hydrolysis by-products. The degradation kinetics were followed by positive identification of the hydrolysis fragments by chromatographic methods, by amino acid an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964980
更新日期：1985-10-01 00:00:00
abstract：:Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1360-9
更新日期：2014-09-01 00:00:00
abstract：:The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963985
更新日期：1984-03-01 00:00:00
abstract：:With the aid of histochemical and electrophoretic techniques activities for esterase and esterprotease were investigated in the digastric and masseter muscles from normal and dystrophic mice. The substrates used were alpha-naphthyl acetate and N-acetyl-L-alanine alpha-naphthyl ester. According to the microscopic obser...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971312
更新日期：1989-03-01 00:00:00
abstract：:We measured the activity of several acid hydrolases in oligodendrocyte and mixed glial (predominantly astrocytic) cell cultures prepared from neonatal rat cerebra. When compared with the mixed glial cultures, the cultured oligodendrocytes exhibited higher levels for all the hydrolases when activities were normalized t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970764
更新日期：1988-10-01 00:00:00
abstract：:Rat obturator nerve 16S acetylcholinesterase (16S AChE) was separated by sucrose gradient velocity sedimentation and compared to the 16S form of AChE similarly derived from endplate regions of anterior gracilis muscles. The 16S AChE from both tissues could only be extracted in high ionic strength buffer; as it aggrega...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965031
更新日期：1981-09-01 00:00:00
abstract：:Alzheimer's disease (AD) is pathologically characterized by presence of senile plaques in the hippocampus, which are composed mainly of extracellular deposition of a polypeptide known as the beta amyloid, the Aβ. It has been demonstrated on numerous occasions that it was the deposition and aggregation of this Aβ pepti...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0846-6
更新日期：2012-10-01 00:00:00
abstract：:Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0327-8
更新日期：2011-02-01 00:00:00
abstract：:Calpains, cathepsins and caspases play crucial role in mediating cell death. In the present study we observed a cascade of events involving the three proteases during middle cerebral artery occlusion (MCAo) in Wistar rats. The rats were MCA occluded and reperfused at various time points. We observed a maximal increase...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9567-7
更新日期：2008-11-01 00:00:00
abstract：:Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1729-4
更新日期：2015-10-01 00:00:00
abstract：:The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02839-9
更新日期：2019-08-01 00:00:00
abstract：:Consumption of fifteen percent alcohol, during gestation did not cause any decrease in the total calorie or fluid intake of the rats maintained on normal dietary regimen. However, the alcohol consumption by gestating mothers resulted in a decreased contents of both DNA and protein in the CNS of the in utero alcohol ex...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965614
更新日期：1989-11-01 00:00:00
abstract：:We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9751-4
更新日期：2008-10-01 00:00:00
abstract：:The mutual interactions and the effects of GABA on the saturable transport components of taurine and hypotaurine were investigated with mouse brain slices. The low-affinity taurine transport was competitively inhibited by both hypotaurine and GABA. Hypotaurine did not alter the kinetic parameters of high-affinity taur...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964995
更新日期：1983-11-01 00:00:00
abstract：:Addiction is a debilitating, chronic psychiatric disorder that is difficult to cure completely owing to the high rate of relapse. Behavioral sensitization is considered to may underlie behavioral changes, such as relapse, caused by chronic abuse of psychomotor stimulants. Thus, its animal models have been widely used ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1976-z
更新日期：2016-10-01 00:00:00
abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9527-2
更新日期：2008-02-01 00:00:00
abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03138-4
更新日期：2020-12-01 00:00:00
abstract：:The putative dopamine D4 receptor protein in rat brain was labelled and quantified autoradiographically using two selective benzamides: [3H]YM-09151-2 which labels D2, D3 and D4 dopamine receptors and [3H]Raclopride which labels D2 and D3. The difference in densities of both ligands at saturable concentrations, show a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027399408608
更新日期：1997-04-01 00:00:00
abstract：:The efflux kinetics of 45Ca from rat brain cortex thin slices previously equilibrated with it, was studied in a superfusion system. Two first order kinetic components of efflux from the tissue were found: k2 = 0.0667 min-1, that was unchanged by lowering the temperature from 37 degrees C to 15 degrees, and k3 = 0.0167...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966071
更新日期：1982-11-01 00:00:00
abstract：:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966062
更新日期：1982-11-01 00:00:00
abstract：:Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that is activated mostly by association with its activators, p35 and p39. Initially projected as a neuron-specific kinase, cdk5 is expressed ubiquitously and its kinase activity solely depends on the presence of its activators, which are al...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-008-9885-4
更新日期：2009-06-01 00:00:00
