Abstract:
:Mevalonate phosphorylation was studied in neonatal chick brain. Formation of phosphorylated derivatives of mevalonic acid increased with the pH in the range assays (5.5-9.5). Phosphomevalonate kinase was completely inactivated after treatment at 50 degree C for 5-10 min, whereas mevalonate kinase was found to retain its activity under the same conditions. Exposure to 65 degree C for 5 min resulted in the inactivation of mevalonate kinase. Both mevalonate-activating enzymes from chick brain were located primarily in the soluble fraction. The amounts of phosphomevalonic acid and pyrophosphomevalonic acid did not show a significant diurnal variation to suggest the presence of a circadian rhythm in either kinase. Cholesterol feeding and fasting had no effect on mevalonate phosphorylation by neonatal chick brain.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Linares A,Aguilera JA,García-Peregrín Edoi
10.1007/BF00965047subject
Has Abstractpub_date
1981-08-01 00:00:00pages
893-900issue
8eissn
0364-3190issn
1573-6903journal_volume
6pub_type
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