Abstract:
:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetylcholine receptor antagonist. Different behavior tests including the Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. Scopolamine significantly decreased the spontaneous alternation and step-through latency of C57BL/6J mice in Y-maze test and passive avoidance test, whereas increased the time of mice spent to find the hidden platform in Morris water maze test. Importantly, intraperitoneal administration of P7C3 effectively reversed those Scopolamine-induced cognitive impairments in C57BL/6J mice. Furthermore, P7C3 treatment significantly enhanced the level of brain-derived neurotrophic factor (BDNF) signaling pathway in the cortex and hippocampus, and the usage of selective BDNF signaling inhibitor fully blocked the anti-amnesic effects of P7C3. Therefore, these findings suggest that P7C3 could improve the scopolamine-induced learning and memory impairment possibly through activation of BDNF signaling pathway, thereby exhibiting a cognition-enhancing potential.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Jiang B,Song L,Huang C,Zhang Wdoi
10.1007/s11064-015-1783-ysubject
Has Abstractpub_date
2016-05-01 00:00:00pages
1010-9issue
5eissn
0364-3190issn
1573-6903pii
10.1007/s11064-015-1783-yjournal_volume
41pub_type
杂志文章abstract::The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...
journal_title:Neurochemical research
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doi:10.1007/s11064-014-1262-x
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journal_title:Neurochemical research
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更新日期:1989-12-01 00:00:00
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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doi:10.1007/s11064-017-2354-1
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
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