The Extract of Leonurus sibiricus Transgenic Roots with AtPAP1 Transcriptional Factor Induces Apoptosis via DNA Damage and Down Regulation of Selected Epigenetic Factors in Human Cancer Cells.

abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...

journal_title：Neurochemical research

authors： Morell P,Jurevics H

更新日期：1996-04-01 00:00:00

abstract：:Selective blockade of a subset of GABA(A) receptors may be involved in the antipsychotic effects of Clozapine and several other antipsychotic drugs. Seven antipsychotic drugs, and 11 drugs classified as antidepressants that only partially reverse the inhibitory effect of 1 microM GABA on [35S]TBPS binding, do not yiel...

journal_title：Neurochemical research

authors： Squires RF,Saederup E

更新日期：1997-02-01 00:00:00

abstract：:The finding that ketamine, an anaesthetic, can elicit a rapid antidepressant effect at low doses that lasts for weeks in patients with depression is arguably a major achievement in psychiatry in the last decades. However, the mechanisms of action are unclear. The glutamatergic hypothesis of ketamine action posits that...

journal_title：Neurochemical research

authors： Stenovec M,Božić M,Pirnat S,Zorec R

更新日期：2020-01-01 00:00:00

abstract：:Zinc (Zn2+) was shown to invariably inhibit muscimol-stimulated 36Cl- uptake by synaptoneurosomes in the cerebral cortex, hippocampus and cerebellum. The Zn2+ sensitivity of the GABAA receptor-gated 36Cl- uptake in the cerebral cortex was comparable to that in the hippocampus, whereas the uptake in the cerebellum was ...

journal_title：Neurochemical research

authors： Ito Y,Segawa K,Kobayashi M,Fukuda H

更新日期：1996-08-01 00:00:00

abstract：:Donepezil is a selective inhibitor of acetylcholinesterase (AChE) clinically used for treating Alzheimer's disease. Cholinergic effects after short-term exposure of donepezil (up to 12 h) have been extensively studied in rats, but few have addressed the potential long-term effects. After 14 days administration (1x3 mg...

journal_title：Neurochemical research

authors： Haug KH,Bogen IL,Osmundsen H,Walaas I,Fonnum F

更新日期：2005-12-01 00:00:00

abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...

journal_title：Neurochemical research

authors： Trevisan C,DiMauro S

更新日期：1983-05-01 00:00:00

abstract：:It is reported that CNS hemorrhage causes membrane dysfunction and may exacerbate this damage as a result of secondary ischemia or hypoxia. Since hyperbaric oxygenation improves oxygen metabolism, it may reduce this membrane damage. The present study was conducted to reveal whether hyperbaric oxygenation influences me...

journal_title：Neurochemical research

authors： Yufu K,Itoh T,Edamatsu R,Mori A,Hirakawa M

更新日期：1993-09-01 00:00:00

abstract：:Implication of protein phosphatases in Alzheimer disease led us to a systemic investigation of the identification of these enzyme activities in human brain. Human brain phosphatases eluted from DEAE-Sephacel with 0.22 M NaCl were resolved into two main groups by affi-gel blue chromatography, namely affi-gel blue-bindi...

journal_title：Neurochemical research

authors： Cheng LY,Wang JZ,Gong CX,Pei JJ,Zaidi T,Grundke-Iqbal I,Iqbal K

更新日期：2000-01-01 00:00:00

abstract：:Cold restraint stress (CRS) model exerts similar effect as physiological stress because it combines emotional stress (escape reaction) and physical stress (muscle work). It is well established that various responses to stress are regulated by sympathoadrenal system, brain monoaminergic systems and oxidative processes....

journal_title：Neurochemical research

authors： Lyle N,Chakrabarti S,Sur T,Gomes A,Bhattacharyya D

更新日期：2012-12-01 00:00:00

abstract：:Age-related increase of reactive oxygen species (ROS) is particularly detrimental in postmitotic tissues. Calorie restriction (CR) has been shown to exert beneficial effects, consistent with reduced ROS generation by mitochondria. Many antioxidant compounds also mimic such effects. N-acetyl cysteine (NAC) provides thi...

journal_title：Neurochemical research

authors： Nicoletti VG,Marino VM,Cuppari C,Licciardello D,Patti D,Purrello VS,Stella AM

更新日期：2005-06-01 00:00:00

abstract：:Metal ions are often used to block calcium channels in various tissues, including synaptosomes. In the present study, Fura-2 was used to determine the effectiveness of various metal ions as calcium channel blockers in rat brain synaptosomes in vitro. In buffer solutions, La3+ and Cd2+ increased the Fura-2 fluorescence...

journal_title：Neurochemical research

authors： Sun YD,Benishin CG

更新日期：1989-11-01 00:00:00

abstract：:It has been proposed that taurine may function as an oxidant in a dose-dependent manner in vivo and in vitro. The present study was carried out to investigate the relationship between taurine concentration and 3-nitrotyrosine level, a stable marker of peroxynitrite action, in hepatocytes of guinea pig in endotoxemia b...

journal_title：Neurochemical research

authors： Erdamar H,Türközkan N,Balabanli B,Ozan G,Bircan FS

更新日期：2007-11-01 00:00:00

abstract：:In the present study mitochondrial respiratory function of fibroblasts from a patient affected by early-onset parkinsonism carrying the homozygous W437X nonsense mutation in the PINK1 gene has been thoroughly characterized. When compared with normal fibroblasts, the patient's fibroblast mitochondria exhibited a lower ...

journal_title：Neurochemical research

authors： Piccoli C,Sardanelli A,Scrima R,Ripoli M,Quarato G,D'Aprile A,Bellomo F,Scacco S,De Michele G,Filla A,Iuso A,Boffoli D,Capitanio N,Papa S

更新日期：2008-12-01 00:00:00

abstract：:The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been epidemiologically associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases. Flavonoid glycosides, the main class of flavonoids, have been shown to exert CNS-mediated activities, p...

journal_title：Neurochemical research

authors： Fernandez SP,Nguyen M,Yow TT,Chu C,Johnston GA,Hanrahan JR,Chebib M

更新日期：2009-10-01 00:00:00

abstract：:Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...

journal_title：Neurochemical research

authors： Maurer MH,Feldmann RE Jr,Fütterer CD,Butlin J,Kuschinsky W

更新日期：2004-06-01 00:00:00

abstract：:The purpose of this study was to investigate whether the kappa-opioid receptor (KOR) agonist, BRL52537, has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in rats and further explore the underlying mechanisms. Adult male Sprague-Dawley rats were randomly assigned into sham (group A), I/R (...

journal_title：Neurochemical research

authors： Fang S,Xu H,Lu J,Zhu Y,Jiang H

更新日期：2013-11-01 00:00:00

abstract：:Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...

journal_title：Neurochemical research

authors： Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Lee SK,Lee SH,Kim YK

更新日期：2005-08-01 00:00:00

abstract：:Protein kinase A (PKA) plays a crucial role in tau hyperphosphorylation, an early event of Alzheimer disease (AD), and 17beta-estradiol replacement in aging women forestalls the onset of AD. However, the role of estradiol in PKA-induced tau hyperphosphorylation is not known. Here, we investigated the effect of 17beta-...

journal_title：Neurochemical research

authors： Liu XA,Zhu LQ,Zhang Q,Shi HR,Wang SH,Wang Q,Wang JZ

更新日期：2008-09-01 00:00:00

abstract：:Transgenic therapy for central neuralgia faces the problems of low expression and weak targeting and affects superficial but not deep neurons. In this study, we generated a lentivirus vector with human preproenkephalin gene (hPPE) expression driven by the transcriptional amplification strategy system (TAS) and establi...

journal_title：Neurochemical research

authors： Yang J,Zhang L,Xie P,Pan M,Ma G

更新日期：2020-09-01 00:00:00

abstract：:To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...

journal_title：Neurochemical research

authors： Tanaka K,Asanuma M,Ogawa N

更新日期：2004-08-01 00:00:00

abstract：:Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in ...

journal_title：Neurochemical research

authors： Basha PM,Poojary A

更新日期：2011-02-01 00:00:00

abstract：:Spinal cord injury (SCI) is a type of long-term disability with a high morbidity rate in clinical settings for which there is no effective clinical treatment to date. Usually, lithium is used as a popular mood stabilizer. Recently, growing evidence has shown that lithium has clear neuroprotective effects after SCI, an...

journal_title：Neurochemical research

authors： Li B,Ren J,Yang L,Li X,Sun G,Xia M

更新日期：2018-04-01 00:00:00

abstract：:It is now established that (1) concentrations of 2-phenylethylamine (PEA) are greatly increased in brain following administration of monoamine oxidase inhibitor (MAOI) antidepressants; (2) PEA is a metabolite of the MAOI antidepressant phenelzine; and (3) PEA may be a neuromodulator of catecholamine activity. On the b...

journal_title：Neurochemical research

authors： Paetsch PR,Greenshaw AJ

更新日期：1993-09-01 00:00:00

abstract：:Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysi...

journal_title：Neurochemical research

authors： Borowicz-Reutt KK,Banach M,Piskorska B

更新日期：2016-05-01 00:00:00

abstract：:Radioactive 125I seeds-based radiotherapy has achieved great success in treatment of human cancers. However, radioresistance and severe side effects badly limited its clinic application. Recently, chemoradiotherapy as a superior strategy has been rapidly developed and widely used in clinic. However, the underlying mec...

journal_title：Neurochemical research

authors： Liu C,Wang L,Qiu H,Dong Q,Feng Y,Li D,Li C,Fan C

更新日期：2018-07-01 00:00:00

abstract：:During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering multiple cellular responses to injury. Here, we evaluated changes in extracellular ATP, ADP and AMP hydrolysis at different times (0-24 hours) after unilateral cortical stab injury (CSI) in adul...

journal_title：Neurochemical research

authors： Nedeljkovic N,Bjelobaba I,Lavrnja I,Stojkov D,Pekovic S,Rakic L,Stojiljkovic M

更新日期：2008-05-01 00:00:00

abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...

journal_title：Neurochemical research

authors： Liu P,Zhao P,Li B,Xu D,Wang K

更新日期：2020-12-01 00:00:00

abstract：:Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...

journal_title：Neurochemical research

authors： Heinämäki AA,Muhonen AS,Piha RS

更新日期：1986-04-01 00:00:00

abstract：:Glucocorticoid receptors (GRs) exert actions on the hippocampus that are important for memory formation. There are correlations between vascular dysfunctions and GR-related gene expression. Both vascular dysfunction and GR gene expression decline occur during the ageing process. Therefore, hypotensors, which have effe...

journal_title：Neurochemical research

authors： Li X,Ma J,Xu J,Zhu D,Li A,Che Y,Chen D,Feng X

更新日期：2017-11-01 00:00:00

abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...

journal_title：Neurochemical research

authors： Ivanov TR,Brown IR

更新日期：1989-02-01 00:00:00