Genes expressed in cortical neurons--chromatin conformation and DNase I hypersensitive sites.

abstract：:It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes...

journal_title：Neurochemical research

authors： Saito M,Smiley J,Toth R,Vadasz C

更新日期：2002-10-01 00:00:00

abstract：:Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide a...

journal_title：Neurochemical research

authors： Kaufman S

更新日期：1991-09-01 00:00:00

abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...

journal_title：Neurochemical research

authors： Jeong JI,Lee YW,Kim YK

更新日期：2003-08-01 00:00:00

abstract：:The first mentioning of the word "receptor" for the structure with which a bioactive compound should react for obtaining its specific influence on a physiological system goes back to the years around 1900. The receptor concept was adapted from the lock and key theory for the enzyme substrate and blockers interactions....

journal_title：Neurochemical research

authors： Kooistra AJ,de Graaf C,Timmerman H

更新日期：2014-10-01 00:00:00

abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...

journal_title：Neurochemical research

authors： Shen Y,Zhao H,Li P,Peng Y,Cui P,Miao F,Zhang Y,Zhang A,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...

journal_title：Neurochemical research

authors： An L,Li G,Si J,Zhang C,Han X,Wang S,Jiang L,Xie K

更新日期：2016-05-01 00:00:00

abstract：:Schwann cell biosynthesis of glycolipids was studied by in vitro incorporation of [3H]galactose into neonatal rat sciatic nerves before and after endoneurial explant culture and in culture of purified Schwann cells. In neonatal nerves prior to culture, [3H]galactose was actively incorporated into galactocerebrosides (...

journal_title：Neurochemical research

authors： Yao JK,Windebank AJ,Poduslo JF,Yoshino JE

更新日期：1990-03-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:This study was designed to investigate the effects of chronic toluene inhalation in high concentration on lipid peroxidation, antioxidant enzyme activities and ultrastructural changes in the sciatic nerves of rats. Male Wistar albino rats (150-250 g) were divided in two experimental groups: the control and the toluene...

journal_title：Neurochemical research

authors： Coskun O,Oter S,Korkmaz A,Armutcu F,Kanter M

更新日期：2005-01-01 00:00:00

abstract：:Human dental follicle cells (DFCs) are ectomesenchymal multipotent stem cells that form spheroid cell clusters (SCCs) under serum free medium cell culture conditions (SFM). Until today, molecular mechanisms for the formation of SCCs are unknown. In this study a quantitative phosphoproteomics approach revealed regulate...

journal_title：Neurochemical research

authors： Beck HC,Gosau M,Kristensen LP,Morsczeck C

更新日期：2014-07-01 00:00:00

abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...

journal_title：Neurochemical research

authors： Rostas JA,Jeffrey PL

更新日期：1977-02-01 00:00:00

abstract：:Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to identify genes whose expression is modulated due to the over-expression of human mutant presenilin-2 (N141I) (hPS2m) in transgenic mice, which has previously been p...

journal_title：Neurochemical research

authors： Hwang DY,Cho JS,Oh JH,Shim SB,Jee SW,Lee SH,Seo SJ,Lee SK,Lee SH,Kim YK

更新日期：2005-08-01 00:00:00

abstract：:A hemagglutinating activity was detected in a synaptic vesicle-enriched fraction prepared from adult rat brain, using trypsinized glutaraldehyde-fixed rabbit erythrocytes. The specific activity of the fraction, in two series of experiments, was 7.5 and 16-fold higher than in the other subcellular fractions. The activi...

journal_title：Neurochemical research

authors： Popoli M,Mengano A

更新日期：1988-01-01 00:00:00

abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...

journal_title：Neurochemical research

authors： Benjamins JA,Nedelkoska L

更新日期：2007-02-01 00:00:00

abstract：:A study was undertaken in rats to evaluate the effects of short-term oral ethanol administration on the levels of fatty acid ethyl esters (FAEE) in brain and peripheral organs in the presence and absence of pretreatment with L-carnitine. Administration of ethanol to rats for seven days resulted in fatty acid ethyl est...

journal_title：Neurochemical research

authors： Calabrese V,Rizza V

更新日期：1999-01-01 00:00:00

abstract：:Cysteinyl leukotrienes (CysLTs) are potent pro-inflammatory and immune modulating lipid mediators involved in inflammatory diseases and were boosted in human brain after acute phase of cerebral ischemia. The antagonism of CysLTs receptors may offer protection against ischemic damage. Therefore it seemed interesting to...

journal_title：Neurochemical research

authors： Saad MA,Abdelsalam RM,Kenawy SA,Attia AS

更新日期：2015-01-01 00:00:00

abstract：:Mice infected with the Venezuelan equine encephalomyelitis virus showed a significant decrease in the GABA content of cerebral hemispheres. Activity of the enzyme which synthetizes GABA, glutamate decarboxylase, is also reduced in whole cerebral hemispheres, neostriatum, and frontal cortex of infected animals, as comp...

journal_title：Neurochemical research

authors： Bonilla E,Ryder E,Ryder S

更新日期：1980-02-01 00:00:00

abstract：:The human formyl peptide receptor like 1 (FPRL-1) is a variant of the Gi-coupled formyl-peptide receptor. Functional FPRL-1 is endogenously expressed in the U87 astrocytoma cell line and there is accumulating evidence to suggest that FPRL-1 may be involved in neuroinflammation associated with the pathogenesis of Alzhe...

journal_title：Neurochemical research

authors： Kwan DH,Kam AY,Wong YH

更新日期：2008-01-01 00:00:00

abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...

journal_title：Neurochemical research

authors： Vacotto M,Rapacioli M,Flores V,de Plazas SF

更新日期：2010-10-01 00:00:00

abstract：:Sonic hedgehog (Shh), a secreted glycoprotein factor, can activate the Shh pathway, which has been implicated in neuronal polarization involving neurite outgrowth. However, little evidence is available about the effect of Shh on neurite outgrowth in primary cortical neurons and its potential mechanism. Here, we reveal...

journal_title：Neurochemical research

authors： He W,Cui L,Zhang C,Zhang X,He J,Xie Y

更新日期：2016-04-01 00:00:00

abstract：:Endoplasmic reticulum (ER) and mitochondria are intracellular organelles and their interactions are directly involved in different processes such as Ca(2+) signaling in cell survival and death mechanisms. Bcl-2 is an anti-apoptotic protein intrinsically related to ER and mitochondria, modulating Ca(2+) content in thes...

journal_title：Neurochemical research

authors： Hirata H,Lopes GS,Jurkiewicz A,Garcez-do-Carmo L,Smaili SS

更新日期：2012-02-01 00:00:00

abstract：:Selective and limited proteolysis is a key step in the post-translational modification of peptide hormone precursors. This process appears to involve a proteolytic machinery including highly specific endoproteases. Some of the enzyme systems possibly involved in the processing of pro-neuropeptides will be described an...

journal_title：Neurochemical research

authors： Gluschankof P,Cohen P

更新日期：1987-10-01 00:00:00

abstract：:Memory impairment is a major problem afflicting mankind. The association between memory functions and neurotransmitter functions is of great interest for understanding brain function. Serotonergic pathways play an important role in the modulation of memory functions but the importance of its receptor types and subtype...

journal_title：Neurochemical research

authors： Haider S,Khaliq S,Tabassum S,Haleem DJ

更新日期：2012-10-01 00:00:00

abstract：:Status epilepticus (SE) is a severe clinical manifestation of epilepsy associated with intense neuronal loss and inflammation, two key factors involved in the pathophysiology of temporal lobe epilepsy. Bone marrow mononuclear cells (BMMC) attenuated the consequences of pilocarpine-induced SE, including neuronal loss, ...

journal_title：Neurochemical research

authors： Leal MM,Costa-Ferro ZS,Souza BS,Azevedo CM,Carvalho TM,Kaneto CM,Carvalho RH,Dos Santos RR,Soares MB

更新日期：2014-02-01 00:00:00

abstract：:The recent publication of the human genome sequence provides an opportunity both to combat diseases that are presently considered as pharmaceutically intractable and also to improve current therapies for many common human diseases. The identification of every human gene by ongoing bioinformatic efforts has the potenti...

journal_title：Neurochemical research

authors： Butcher SP

更新日期：2003-02-01 00:00:00

abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...

journal_title：Neurochemical research

authors： Kim JS,Giacobini E

更新日期：1985-10-01 00:00:00

abstract：:Isoleucine, together with leucine and valine, constitutes the group of branched-chain amino acids (BCAAs). BCAAs are transported from the blood into the brain parenchyma, where they can serve several distinct functions. Since brain tissue is known to oxidatively metabolize BCAAs to CO(2), they are considered as fuel m...

journal_title：Neurochemical research

authors： Murín R,Mohammadi G,Leibfritz D,Hamprecht B

更新日期：2009-01-01 00:00:00

abstract：:Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation and chemotherapy, this cancer recurs within short time and median survival after diagnosis is less than a year. Glioblastoma stem cells (GSCs) left in the brain after surgery is thought to explain the inevitable recurre...

journal_title：Neurochemical research

authors： Skjellegrind HK,Fayzullin A,Johnsen EO,Eide L,Langmoen IA,Moe MC,Vik-Mo EO

更新日期：2016-07-01 00:00:00

abstract：:The MAO inhibitor phenelzine (PLZ) at a dose of 25 mg/kg does not affect the behavior of rats. In contrast, the equivalent dose of a deuterated analog (alpha, alpha, beta, beta-tetradeutero-PLZ, d4PLZ) elicits a biphasic behavioral syndrome in rats. In an attempt to correlate changes in cerebral monoamines with behavi...

journal_title：Neurochemical research

authors： Dewar KM,Dyck LE,Durden DA,Boulton AA

更新日期：1988-02-01 00:00:00

abstract：:This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...

journal_title：Neurochemical research

authors： He MH,Cheung ZH,Yu EH,Tay DK,So KF

更新日期：2004-11-01 00:00:00