Abstract:
:Protein kinase A (PKA) plays a crucial role in tau hyperphosphorylation, an early event of Alzheimer disease (AD), and 17beta-estradiol replacement in aging women forestalls the onset of AD. However, the role of estradiol in PKA-induced tau hyperphosphorylation is not known. Here, we investigated the effect of 17beta-estradiol on cAMP/PKA activity and the PKA-induced tau hyperphosphorylation in HEK293 cells stably expressing tau441. We found that 17beta-estradiol effectively attenuated forskolin-induced overactivation of PKA and elevation of cAMP, and thus prevented tau from hyperphosphorylation. These data provide the first evidence that 17beta-estradiol can inhibit PKA overactivation and the PKA-induced tau hyperphosphorylation, implying a preventive role of 17beta-estradiol in AD-like tau pathology.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Liu XA,Zhu LQ,Zhang Q,Shi HR,Wang SH,Wang Q,Wang JZdoi
10.1007/s11064-008-9638-4subject
Has Abstractpub_date
2008-09-01 00:00:00pages
1811-20issue
9eissn
0364-3190issn
1573-6903journal_volume
33pub_type
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