Transplantation of Mesenchymal Stromal Cells Expressing the Human Preproenkephalin Gene Can Relieve Pain in a Rat Model of Neuropathic Pain.

abstract：:The effect of postdecapitative ischemia (5 min at 37 degrees) and hypoxia (5% O2, 95% N2, 30 min) on the distribution of protein radioactivity in the cellular fractions of guinea pig cerebral cortex was studied. Ischemic conditions resulted in the increase of total radioactivity level and protein content in the mitoch...

journal_title：Neurochemical research

authors： Rossowska M,Zalewska T

更新日期：1979-02-01 00:00:00

abstract：:Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-d...

journal_title：Neurochemical research

authors： Gerstner JR,Landry CF

更新日期：2007-02-01 00:00:00

abstract：:Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved i...

journal_title：Neurochemical research

authors： Kawabe K,Takano K,Moriyama M,Nakamura Y

更新日期：2018-01-01 00:00:00

abstract：:Ubiquinone (coenzyme Q10), in addition to its function as an electron and proton carrier in mitochondrial electron transport coupled to ATP synthesis, acts in its reduced form (ubiquinol) as an antioxidant, inhibiting lipid peroxidation in biological membranes and protecting mitochondrial inner-membrane proteins and D...

journal_title：Neurochemical research

authors： Albano CB,Muralikrishnan D,Ebadi M

更新日期：2002-05-01 00:00:00

abstract：:The release of labeled norepinephrine from preloaded synaptosomes requires the presence of potassium and calcium. ATP-dependent binding of calcium to synaptic plasma membranes (SPM) may provide a means of maintaining the cation in a readily available pool for the triggering of transmitter release. A high Ca-binding ca...

journal_title：Neurochemical research

authors： Corpus V,Sun AY

更新日期：1983-04-01 00:00:00

abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...

journal_title：Neurochemical research

authors： Buntup D,Skare O,Solbu TT,Chaudhry FA,Storm-Mathisen J,Thangnipon W

更新日期：2008-02-01 00:00:00

abstract：:Effects of single and repeated doses of acrylamide on fast and slow axonal transport of radio labeled proteins following the injection of L-[4,5-3H] leucine have been studied in the optic system of male Sprague-Dawley rats. A single dose of acrylamide (100 mg/kg) had no effect, but higher concentrations (200-300 mg/kg...

journal_title：Neurochemical research

authors： Sabri MI,Spencer PS

更新日期：1990-06-01 00:00:00

abstract：:Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...

journal_title：Neurochemical research

authors： Mutsuga N,Gainer H

更新日期：2006-02-01 00:00:00

abstract：:A number of axonal proteins display changes in phosphorylation during goldfish optic nerve regeneration (Larrivee and Grafstein, 1989). (1) To determine whether the phosphorylation of these proteins was closely linked to their synthesis in the retinal ganglion cell body, cycloheximide was injected intraocularly into g...

journal_title：Neurochemical research

authors： Larrivee D

更新日期：1990-09-01 00:00:00

abstract：:Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...

journal_title：Neurochemical research

authors： Henderson NS,Tweedle CD,Kabara JJ

更新日期：1980-12-01 00:00:00

abstract：:Cholinesterase activities in rat forebrain, erythrocytes, and plasma were assessed after a single oral administration of metrifonate or dichlorvos. In 3-month-old rats, the dichlorvos (10 mg/kg p.o.)induced inhibition of cholinesterase reached its peak in brain after l5-45 min and after 10-30 min in erythrocytes and p...

journal_title：Neurochemical research

authors： Hinz V,Grewig S,Schmidt BH

更新日期：1996-03-01 00:00:00

abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...

journal_title：Neurochemical research

authors： Cushman JD,Moore MD,Olsen RW,Fanselow MS

更新日期：2014-06-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected. ...

journal_title：Neurochemical research

authors： Monfil T,Vázquez Roque RA,Camacho-Abrego I,Tendilla-Beltran H,Iannitti T,Meneses-Morales I,Aguilar-Alonso P,Flores G,Morales-Medina JC

更新日期：2018-02-01 00:00:00

abstract：:This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...

journal_title：Neurochemical research

authors： He MH,Cheung ZH,Yu EH,Tay DK,So KF

更新日期：2004-11-01 00:00:00

abstract：:Several lines of evidence indicate that ATP may play an important role in Long-Term Potentiation. In this investigation we evaluated the effect of a memory task (step-down inhibitory avoidance) on the synaptosomal ecto-enzymes (ATP diphosphohydrolase and 5'-nucleotidase) involved in the degradation of ATP to adenosine...

journal_title：Neurochemical research

authors： Bonan CD,Dias MM,Battastini AM,Dias RD,Sarkis JJ

更新日期：1998-07-01 00:00:00

abstract：:The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...

journal_title：Neurochemical research

authors： Yoshino Y

更新日期：1984-03-01 00:00:00

abstract：:Several models for the transmission and progression of prion diseases have arisen, evolving with the acquisition of new experimental results. It is generally accepted that the PrP(Sc) protein is at least part of the infectious particle and the major protein component of the scrapie-associated fibrils (SAFs) that chara...

journal_title：Neurochemical research

authors： Grossman A,Zeiler B,Sapirstein V

更新日期：2003-06-01 00:00:00

abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....

journal_title：Neurochemical research

authors： Lai JC,Sheu KF

更新日期：1987-08-01 00:00:00

abstract：:Staurosporine was found to bring about complete growth inhibition of human glioma cell lines. U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine tre...

journal_title：Neurochemical research

authors： Harmalkar MN,Shirsat NV

更新日期：2006-05-01 00:00:00

abstract：:Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...

journal_title：Neurochemical research

authors： Galoyan AA,Gurvitz BYa,Sharova NP

更新日期：1989-12-01 00:00:00

abstract：:The elevated plus maze (EPM) is an animal model of anxiety used to test the effects of anxioselective drugs. The loss of the anxiolytic effect of drugs during the second exposure to the EPM is called the "one trial tolerance" (OTT) phenomenon. The present study was designed to investigate the relationship between the ...

journal_title：Neurochemical research

authors： Kocahan S,Akillioglu K

更新日期：2013-07-01 00:00:00

abstract：:Social isolation during early development is one of the most potent stressors that can cause alterations in the processes of brain maturation, leading to behavioral and neurochemical changes that may persist to adulthood. Exposure to palatable diets during development can also affect neural circuits with long-term con...

journal_title：Neurochemical research

authors： Arcego DM,Krolow R,Lampert C,Noschang C,Pettenuzzo LF,Marcolin ML,Toniazzo AP,Dalmaz C

更新日期：2013-09-01 00:00:00

abstract：:We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (t...

journal_title：Neurochemical research

authors： Ishrat T,Pillai B,Ergul A,Hafez S,Fagan SC

更新日期：2013-12-01 00:00:00

abstract：:The maximal rate of some cerebral enzymatic activities related to energy transduction (hexokinase; phosphofructokinase; lactate dehydrogenase; citrate synthase; malate dehydrogenase; total NADH-cytochrome c reductase; cytochrome oxidase), amino acid metabolism (glutamate decarboxylase; glutamate dehydrogenase) and cho...

journal_title：Neurochemical research

authors： Villa RF,Marzatico F,Benzi G

更新日期：1983-02-01 00:00:00

abstract：:The purpose of this study was to investigate whether the kappa-opioid receptor (KOR) agonist, BRL52537, has a neuroprotective effect against cerebral ischemia/reperfusion (I/R) injury in rats and further explore the underlying mechanisms. Adult male Sprague-Dawley rats were randomly assigned into sham (group A), I/R (...

journal_title：Neurochemical research

authors： Fang S,Xu H,Lu J,Zhu Y,Jiang H

更新日期：2013-11-01 00:00:00

abstract：:Zonisamide (ZNS), an antiepileptic drug having beneficial effects also against Parkinson's disease symptoms, has proven to display an antioxidant effects in different experimental models. In the present study, the effects of ZNS on rotenone-induced cell injury were investigated in human neuroblastoma SH-SY5Y cells dif...

journal_title：Neurochemical research

authors： Condello S,Currò M,Ferlazzo N,Costa G,Visalli G,Caccamo D,Pisani LR,Costa C,Calabresi P,Ientile R,Pisani F

更新日期：2013-12-01 00:00:00

abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...

journal_title：Neurochemical research

authors： Brockerhoff H,Wisniewski HM,Lipton LC,Deshmukh DS

更新日期：1980-06-01 00:00:00

abstract：:The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when admi...

journal_title：Neurochemical research

authors： Stefanovich V

更新日期：1979-10-01 00:00:00

abstract：:We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory. Although it has been shown that mGlu5 signalling is required for certain forms of learning and memory, its role in spatial learning is unclear since studies using pharmacological or knockout mice models provid...

journal_title：Neurochemical research

authors： Tan SZ,Ganella DE,Dick AL,Duncan JR,Ong-Palsson E,Bathgate RA,Kim JH,Lawrence AJ

更新日期：2015-06-01 00:00:00

abstract：:The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...

journal_title：Neurochemical research

authors： Nadler JV

更新日期：2011-04-01 00:00:00