Effect of hypoxia and ischemia on the distribution of protein in brain cellular fractions.

abstract：:Silibinin has been widely used to treat liver diseases due to its antioxidant activity. However, the effects of silibinin on the central nervous system have not been thoroughly investigated. The pathological hallmarks of Alzheimer's disease are the accumulation of amyloid β protein, development of neurofibrillary tang...

journal_title：Neurochemical research

authors： Bai D,Jin G,Yin S,Zou D,Zhu Q,Yang Z,Liu X,Ren L,Sun Y,Gan S

更新日期：2017-12-01 00:00:00

abstract：:Evidence suggests that apoptosis contributes significantly to cell death after cerebral ischemia. Our recent studies that utilized human umbilical cord blood-derived mesenchymal stem cells (hUCBSCs) demonstrated the potential of hUCBSCs to inhibit neuronal apoptosis in a rat model of CNS injury. Therefore, we hypothes...

journal_title：Neurochemical research

authors： Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Veeravalli KK

更新日期：2014-08-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:In this communication, the effect of acute treatment with lamotrigine (LTG) was investigated on release of main excitatory amino acids (EAA) such as glutamate (Glu) and aspartate (Asp) in the hippocampus of pentylenetetrazol (PTZ)-induced and PTZ-kindled freely moving rats using micro dialysis. The results show that, ...

journal_title：Neurochemical research

authors： Deng Y,Wang M,Wang W,Ma C,He N

更新日期：2013-03-01 00:00:00

abstract：:During evolution, living organisms develop a specialized apparatus called nociceptors to sense their environment and avoid hazardous situations. Intense stimulation of high threshold C- and Adelta-fibers of nociceptive primary sensory neurons will elicit pain, which is acute and protective under normal conditions. A f...

journal_title：Neurochemical research

authors： Cheng JK,Ji RR

更新日期：2008-10-01 00:00:00

abstract：:Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using ...

journal_title：Neurochemical research

authors： Jung WY,Kim H,Jeon SJ,Park HJ,Choi HJ,Kim NJ,Kim DH,Jang DS,Ryu JH

更新日期：2018-02-01 00:00:00

abstract：:We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some...

journal_title：Neurochemical research

authors： Sacks W,Cowburn D,Bigler RE,Sacks S,Fleischer A

更新日期：1985-02-01 00:00:00

abstract：:Serotonin (5HT) synthesis in brain is influenced by precursor (tryptophan (TRP)) concentrations, which are modified by food ingestion. Hence, in rats, a carbohydrate meal raises brain TRP and 5HT; a protein-containing meal does not, but little attention has focused on differences among dietary proteins. Recently, sing...

journal_title：Neurochemical research

authors： Choi S,DiSilvio B,Fernstrom MH,Fernstrom JD

更新日期：2011-03-01 00:00:00

abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...

journal_title：Neurochemical research

authors： Spector R,Boose B

更新日期：1983-08-01 00:00:00

abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...

journal_title：Neurochemical research

authors： Krumins SA,Lutz RA,Costa T,Rodbard D

更新日期：1986-06-01 00:00:00

abstract：:A double ligand enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against brain tissue antigens in the sera of patients with neurological diseases. The sera were tested on human white matter homogenate. The technique consists of successive incubations with the human serum to be tested, ...

journal_title：Neurochemical research

authors： Bologa L,Hofstetter W,Schonenberger K,Jacque C,Herschkowitz N

更新日期：1985-04-01 00:00:00

abstract：:The 7S NGF complex from the male mouse submaxillary gland consists of the alpha, gamma, and beta subunits in the ratio alpha 2 gamma 2 beta. The beta (NGF) subunit contains all the known biolocial activity of 7S NGF. The alpha and gamma subunits are both members of glandular kallikrein gene family, yet only gamma subu...

journal_title：Neurochemical research

authors： Burcham TS,Sim I,Bolin LM,Shooter EM

更新日期：1991-06-01 00:00:00

abstract：:The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M1AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did no...

journal_title：Neurochemical research

authors： Pintor A,Fortuna S,Lorenzini P,Pascale A,Battaini F,Avellino C,Malvezzi Campeggi L,Salvati S

更新日期：1996-05-01 00:00:00

abstract：:Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports i...

journal_title：Neurochemical research

authors： de Oliveira MR

更新日期：2016-06-01 00:00:00

abstract：:The chemical warfare nerve agent (CWNA) soman irreversibly inhibits acetylcholinesterase (AChE) causing seizure, neuropathology and neurobehavioral deficits. Pyridostigmine bromide (PB), the currently approved pretreatment for soman, is a reversible AChE inhibitor that does not cross the blood-brain barrier (BBB) to p...

journal_title：Neurochemical research

authors： Wang Y,Wei Y,Oguntayo S,Jensen N,Doctor BP,Nambiar MP

更新日期：2011-12-01 00:00:00

abstract：:Here we review experimental evidence of non-NMDA glutamate receptor expression in the embryonic central nervous system. AMPA- and kainate-preferring glutamate receptor subunit mRNA transcripts are detected in embryonic neurons, glia and neural progenitors. Functional assays demonstrate that in some cell subpopulations...

journal_title：Neurochemical research

authors： Gallo V,Pende M,Scherer S,Molné M,Wright P

更新日期：1995-05-01 00:00:00

abstract：:Pathophysiological concentrations of branched chain keto-acids (BCKAs), such as those that occur in maple syrup urine disease, inhibit oxygen consumption in liver homogenates and brain slices and the enzymatic activity of alpha-ketoglutarate- and pyruvate dehydrogenase complexes. Consistent with previous work, studies...

journal_title：Neurochemical research

authors： Shestopalov AI,Kristal BS

更新日期：2007-04-01 00:00:00

abstract：:"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...

journal_title：Neurochemical research

authors： Ekonomou A,Angelatou F

更新日期：1999-12-01 00:00:00

abstract：:Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of...

journal_title：Neurochemical research

authors： LeBaron FN,Sanyal S,Jungalwala FB

更新日期：1981-10-01 00:00:00

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00

abstract：:The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...

journal_title：Neurochemical research

authors： Selvatici R,Previati M,Marino S,Marani L,Falzarano S,Lanzoni I,Siniscalchi A

更新日期：2009-05-01 00:00:00

abstract：:Prevention and amelioration of Mibyou (sub-healthy condition) is the critical target for disease prevention including age-related diseases and cancer although the Mibyou condition is not yet pathologically defined. Since the oxidative stress is an underlying basic etiology associated with many diseases and aging, the ...

journal_title：Neurochemical research

authors： Konishi T

更新日期：2009-04-01 00:00:00

abstract：:It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...

journal_title：Neurochemical research

authors： Potapenko E,Kostyuk E,Voitenko N,Kostyuk P

更新日期：2004-09-01 00:00:00

abstract：:Astrocytes occupy a strategic position in the brain where they can act as an interface between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This location is ideal for functioning as interoceptors, as they may sense changes in brain microenvironment and contribute to the adaptive homeostatic r...

journal_title：Neurochemical research

authors： Teschemacher AG,Gourine AV,Kasparov S

更新日期：2015-12-01 00:00:00

abstract：:The participation of voltage-sensitive Na+ channels (VSSC) on the changes on internal (i) Na+, K+, Ca2+, and on DA, Glu, and GABA release caused by different concentrations of 4-AP was investigated in striatum synaptosomes. TTX, which abolished the increase in Na(i) (as determined with SBFI), induced by 0.1 mM 4-AP on...

journal_title：Neurochemical research

authors： Galván E,Sitges M

更新日期：2004-02-01 00:00:00

abstract：:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...

journal_title：Neurochemical research

authors： Chechik T,Poduslo SE

更新日期：1987-01-01 00:00:00

abstract：:Neurovascular injury comprises a wide spectrum of pathophysiology that underlies the progression of brain injury after cerebral ischemia. Recently, it has been shown that activation of the integrin-associated protein CD47 mediates the development of blood-brain barrier injury and edema after cerebral ischemia. However...

journal_title：Neurochemical research

authors： Xing C,Arai K,Park KP,Lo EH

更新日期：2010-07-01 00:00:00

abstract：:We have adopted the PC12 cell line as in vitro cell model for studying Dp71 function in neuronal cells. These cells express a cytoplasmic (Dp71f) and a nuclear (Dp71d) isoform of Dp71 as well as various dystrophin-associated proteins (DAPs). In this study, we revealed by confocal microscopy analysis and Western blotti...

journal_title：Neurochemical research

authors： Villarreal-Silva M,Suárez-Sánchez R,Rodríguez-Muñoz R,Mornet D,Cisneros B

更新日期：2010-03-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) and Schwann cells (SCs) are closely-related cell types with regeneration-promoting properties. Comparative gene expression analysis is particularly relevant since it may explain cell type-specific effects and guide the use of each cell type into special clinical applications. In the ...

journal_title：Neurochemical research

authors： Omar M,Hansmann F,Kreutzer R,Kreutzer M,Brandes G,Wewetzer K

更新日期：2013-05-01 00:00:00

abstract：:Tau is a protein involved in regulation of microtubule stability, axonal differentiation and transport. Alteration of retrograde transport may lead to motor neuron degeneration. Thus alternative mRNA splicing and expression of tau isoforms were studied in a transgenic mouse model harboring the human SOD1 G93A mutation...

journal_title：Neurochemical research

authors： Usarek E,Kuźma-Kozakiewicz M,Schwalenstöcker B,Kaźmierczak B,Münch C,Ludolph AC,Barańczyk-Kuźma A

更新日期：2006-05-01 00:00:00