Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells.

abstract：:The efflux kinetics of 45Ca from rat brain cortex thin slices previously equilibrated with it, was studied in a superfusion system. Two first order kinetic components of efflux from the tissue were found: k2 = 0.0667 min-1, that was unchanged by lowering the temperature from 37 degrees C to 15 degrees, and k3 = 0.0167...

journal_title：Neurochemical research

authors： Rubiales de Barioglio S,Orrego F

更新日期：1982-11-01 00:00:00

abstract：:It is reported that CNS hemorrhage causes membrane dysfunction and may exacerbate this damage as a result of secondary ischemia or hypoxia. Since hyperbaric oxygenation improves oxygen metabolism, it may reduce this membrane damage. The present study was conducted to reveal whether hyperbaric oxygenation influences me...

journal_title：Neurochemical research

authors： Yufu K,Itoh T,Edamatsu R,Mori A,Hirakawa M

更新日期：1993-09-01 00:00:00

abstract：:The effects of palmitate on intracellular and extracellular amino acid concentrations of cultured astrocytes was studied. Exposure of astrocytes to either 0.72 mM or 0.36 mM palmitate was associated with a significant reduction in the intracellular pool of glutamine and taurine. In contrast, the intracellular concentr...

journal_title：Neurochemical research

authors： Yudkoff M,Nissim I,Nissim I,Stern J,Pleasure D

更新日期：1989-04-01 00:00:00

abstract：:Analysis of gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological conditions. Although there are many techniques used to measure gene expression the validity of any such experiment is directly related to the quality of the RNA in the samples. The most readily ...

journal_title：Neurochemical research

authors： Van Deerlin VM,Gill LH,Nelson PT

更新日期：2002-10-01 00:00:00

abstract：:The present study addressed the hypothesis that the DA transporter ligand, [3H]mazindol, labels multiple sites/states associated with the dopamine (DA) transporter in striatal membranes. Incubations with [3H]mazindol proceeded for 18-24 hr at 4 degrees C in 55.2 mM sodium phosphate buffer, pH 7.4, with a protease inhi...

journal_title：Neurochemical research

authors： Dersch CM,Akunne HC,Partilla JS,Char GU,de Costa BR,Rice KC,Carroll FI,Rothman RB

更新日期：1994-02-01 00:00:00

abstract：:It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...

journal_title：Neurochemical research

authors： Vacotto M,Rapacioli M,Flores V,de Plazas SF

更新日期：2010-10-01 00:00:00

abstract：:The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...

journal_title：Neurochemical research

authors： Selvatici R,Previati M,Marino S,Marani L,Falzarano S,Lanzoni I,Siniscalchi A

更新日期：2009-05-01 00:00:00

abstract：:The effects of pre-treatment with ENA-713, an acetylcholinesterase (AChE) inhibitor, on changes in pre- and postsynaptic cholinergic indices in gerbil brain following transient ischemia were studied at 4 and 14 days after recirculation. In the ischemic group, hippocampal acetylcholine (ACh) level was significantly red...

journal_title：Neurochemical research

authors： Tanaka K,Ogawa N,Mizukawa K,Asanuma M,Kondo Y,Nishibayashi S,Mori A

更新日期：1994-02-01 00:00:00

abstract：:Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...

journal_title：Neurochemical research

authors： Gong SJ,Chen LY,Zhang M,Gong JX,Ma YX,Zhang JM,Wang YJ,Hu YY,Sun XC,Li WB,Zhang Y

更新日期：2012-03-01 00:00:00

abstract：:Leucine is rapidly metabolized in astroglial primary cultures. Therefore, it is considered as valuable fuel in brain energy metabolism. Only few of the leucine metabolites generated and released by astroglial cells have been identified. Therefore, a more detailed study was performed analyzing by NMR techniques the 13C...

journal_title：Neurochemical research

authors： Bixel MG,Engelmann J,Willker W,Hamprecht B,Leibfritz D

更新日期：2004-11-01 00:00:00

abstract：:Rabbits sensitized with whole nervous tissue or myelin basic protein (MBP) plus adjuvant and developing experimental allergic encephalomyelitis (EAE) were studied for the presence of oligoclonal immunoglobulin (Ig) bands in spinal fluid and serum. Samples obtained prior to sensitization and at the time of sacrifice we...

journal_title：Neurochemical research

authors： Whitacre CC,Mattson DH,Paterson PY,Roos RP,Peterson DJ,Arnason BG

更新日期：1981-01-01 00:00:00

abstract：:Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...

journal_title：Neurochemical research

authors： Lie MEK,Kickinger S,Skovgaard-Petersen J,Ecker GF,Clausen RP,Schousboe A,White HS,Wellendorph P

更新日期：2020-07-01 00:00:00

abstract：:The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocam...

journal_title：Neurochemical research

authors： Kandasamy M,Radhakrishnan RK,Poornimai Abirami GP,Roshan SA,Yesudhas A,Balamuthu K,Prahalathan C,Shanmugaapriya S,Moorthy A,Essa MM,Anusuyadevi M

更新日期：2019-08-01 00:00:00

abstract：:Folic acid plays an important role in neuroplasticity and acts as a neuroprotective agent, as observed in experimental brain ischemia studies. The aim of this study was to investigate the effects of folic acid on locomotor activity, aversive memory and Na(+),K(+)-ATPase activity in the frontal cortex and striatum in a...

journal_title：Neurochemical research

authors： Carletti JV,Deniz BF,Miguel PM,Rojas JJ,Kolling J,Scherer EB,de Souza Wyse AT,Netto CA,Pereira LO

更新日期：2012-08-01 00:00:00

abstract：:We observed that AP-3, an antagonist of metabotropic glutamate receptors, reduced carbachol-induced hydrolysis of phospholipids in hippocampal slices. This inhibition could be explained in different ways, e.g.: 1) AP-3 acts also as antagonist of muscarinic receptors mediating the hydrolysis of phospholipids induced by...

journal_title：Neurochemical research

authors： Llansola M,Hermenegildo C,Miñana MD,Felipo V

更新日期：1998-06-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation,...

journal_title：Neurochemical research

authors： Wei N,Wei Y,Li B,Pang L

更新日期：2017-05-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:Trigeminal neuralgia (TN) is a type of chronic neuropathic pain that is caused by peripheral nerve lesions that result from various conditions, including the compression of vessels, tumors and viral infections. MicroRNAs (miRs) are increasingly recognized as potential regulators of neuropathic pain. Previous evidence ...

journal_title：Neurochemical research

authors： Wang X,Wang H,Zhang T,He M,Liang H,Wang H,Xu L,Chen S,Xu M

更新日期：2019-07-01 00:00:00

abstract：:Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...

journal_title：Neurochemical research

authors： Yarom M,Bao J,Tang XW,Wu E,Lee YH,Tsai WH,Wu JY

更新日期：1992-01-01 00:00:00

abstract：:We examined the impact of peroxiredoxin-I (Prx-I) and peroxiredoxin-II (Prx-II) stable transduction on oxidative stress in PC12 neurons and NIH3T3 fibroblasts and found variability depending on cell type and Prx subtype. In PC12 neurons, Prx-II suppressed reactive oxygen species (ROS) generation by 36% (p < 0.01) rela...

journal_title：Neurochemical research

authors： Simzar S,Ellyin R,Shau H,Sarafian TA

更新日期：2000-12-01 00:00:00

abstract：:Neuronal differentiation and aging are known to involve many genes, which may also be differentially expressed during these developmental processes. From primary cultured cerebral cortical neurons, we have previously identified various differentially expressed gene transcripts from cultured cortical neurons using the ...

journal_title：Neurochemical research

authors： Yu AC,Sun CX,Li Q,Liu HD,Wang CR,Zhao GP,Jin M,Lau LT,Fung YW,Liu S

更新日期：2005-10-01 00:00:00

abstract：:Cloned fragments of members of the Drosophila and mouse major heat shock (hsp70) gene family were used to demonstrate that homologous sequences are present in the rabbit genome. After a physiologically relevant increase in body temperature of 3 degrees C, transcription of inducible hsp70 genes is detected in both the ...

journal_title：Neurochemical research

authors： Brown IR,Lowe DG,Moran LA

更新日期：1985-09-01 00:00:00

abstract：:The extracellular amino acid content was measured in the parietal cortex in portacaval and sham operated rats, using the brain dialysis technique. The amino acid content of the perfusate was determined for 10 min before and during stimulation with potassium chloride. Basal levels of aspartate, glutamine, glycine, meth...

journal_title：Neurochemical research

authors： Tossman U,Delin A,Eriksson LS,Ungerstedt U

更新日期：1987-03-01 00:00:00

abstract：:Exposure of rat pheochromocytoma PC12 cells to 0.1 mM 6-aminonicotinamide (6AN) for 24 hours resulted in a 500-fold increase in 6-phosphogluconate indicating active metabolism of glucose via the oxidative enzymes of the pentose phosphate pathway. Amounts of 6-phosphogluconate that accumulated in 6AN-treated cells at 2...

journal_title：Neurochemical research

authors： Davis LH,Kauffman FC

更新日期：1987-06-01 00:00:00

abstract：:The characteristics and properties of the increase in cytosolic [Ca2+] that occurs in bovine adrenal medullary chromaffin cells on exposure to angiotensin 11 have been investigated. In fura-2 loaded cells exposure to a maximally effective concentration of angiotensin II (100 nM) caused a rapid, but transient increase ...

journal_title：Neurochemical research

authors： Powis DA,Zerbes M,Herd LM,Dunkley PR

更新日期：2003-09-01 00:00:00

abstract：:Abnormal myo-[2-3H]inositol incorporation into phosphatidylinositol has been found in phentolamine-treated synaptosomes that were isolated from the cerebral hemispheres of galactose toxic rats and incubated with [33P]Pi and myo-[2-3H] inositol. In galactose toxic rats phentolamine-stimulated myo-[2-3H]inositol labelin...

journal_title：Neurochemical research

authors： Berry G,Yandrasitz JR,Segal S

更新日期：1982-01-01 00:00:00

abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...

journal_title：Neurochemical research

authors： Schousboe A,Larsson OM,Seiler N

更新日期：1986-11-01 00:00:00

abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...

journal_title：Neurochemical research

authors： Sharma RK,Johnson DA

更新日期：2000-10-01 00:00:00

abstract：:Altered neurogenesis has been reported in Alzheimer disease (AD), the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of β-amyloid (Aβ). Recent studies suggest that tau phosphorylation is essential for hippocampal neurogenesis, however, it is not known whether tau pho...

journal_title：Neurochemical research

authors： Hong XP,Peng CX,Wei W,Tian Q,Liu YH,Cao FY,Wang Q,Wang JZ

更新日期：2011-02-01 00:00:00

abstract：:Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive. The aim of the current study was to determine if targeting oxidative stress with the catalytic antioxidant, AEOL10150, would reduce p...

journal_title：Neurochemical research

authors： Pearson-Smith JN,Liang LP,Rowley SD,Day BJ,Patel M

更新日期：2017-07-01 00:00:00