Abstract：
:Status epilepticus is a common manifestation of nerve agent toxicity and represents a serious medical emergency with high rates of mortality and neurologic injury in those that survive. The aim of the current study was to determine if targeting oxidative stress with the catalytic antioxidant, AEOL10150, would reduce pilocarpine-induced mortality and attenuate neuronal death and neuroinflammation. We found that treatment with AEOL10150 in conjunction with scopolamine and diazepam following pilocarpine-induced SE was able to significantly reduce mortality compared to treatment with just scopolamine and diazepam. Mortality was further reduced when AEOL10150 was used in conjunction with atropine and diazepam which is considered the standard of care for nerve agent exposures. Both treatment paradigms offered significant protection against SE-induced oxidative stress. Additionally, treatment with scopolamine, AEOL10150 and diazepam attenuated SE-induced neuronal loss and neuroinflammation. Taken together, the data suggest that pharmacological targeting of oxidative stress can improve survival and attenuate secondary neurological damage following SE induced by the nerve agent surrogate pilocarpine.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Pearson-Smith JN,Liang LP,Rowley SD,Day BJ,Patel Mdoi
10.1007/s11064-017-2273-1subject
Has Abstractpub_date
2017-07-01 00:00:00pages
2024-2032issue
7eissn
0364-3190issn
1573-6903pii
10.1007/s11064-017-2273-1journal_volume
42pub_type
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