Abstract:
:Rabbits sensitized with whole nervous tissue or myelin basic protein (MBP) plus adjuvant and developing experimental allergic encephalomyelitis (EAE) were studied for the presence of oligoclonal immunoglobulin (Ig) bands in spinal fluid and serum. Samples obtained prior to sensitization and at the time of sacrifice were concentrated and subjected to agar gel electrophoresis. Of 11 rabbits receiving whole nervous tissue and developing severe clinical signs of EAE, 7 showed new oligoclonal Ig bands in spinal fluid and in serum obtained 19 days or more after sensitization. With MBP sensitization, 2 of 6 rabbits exhibited new spinal fluid bands, while all 6 rabbits studied demonstrated serum banding. The bands were identified as IgG by immunochemical studies using peroxidase-labeled antisera and by Staph. protein A absorption. The majority of animals showed no banding in presensitization samples. The finding of oligoclonal IgG in EAE reveals yet another immunologic correlation between EAE and the human demyelinating disease, multiple sclerosis.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Whitacre CC,Mattson DH,Paterson PY,Roos RP,Peterson DJ,Arnason BGdoi
10.1007/BF00963909subject
Has Abstractpub_date
1981-01-01 00:00:00pages
87-96issue
1eissn
0364-3190issn
1573-6903journal_volume
6pub_type
杂志文章abstract::The decline in neuronal function during aging may result from increases in extracellular glutamate (Glu), Glu-induced neurotoxicity, and altered mitochondrial metabolism. To study metabolic responses to persistently high levels of Glu at synapses during aging, we used transgenic (Tg) mice that over-express the enzyme ...
journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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更新日期:1987-04-01 00:00:00
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journal_title:Neurochemical research
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更新日期:1981-04-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973280
更新日期:1988-07-01 00:00:00
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