Abstract：
:Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia in schizophrenic patients in a prolonged neuroleptic treatment course. Haloperidol (HAL) has been hypothesized to increase oxidative stress, while clozapine (CLO) would produce less oxidative damage. The objective was to determine whether CLO for 28 days could reverse or attenuate HAL-induced oxidative damage in animals previously treated with HAL for 28 days. HAL significantly increased thiobarbituric acid reactive substances levels in the cortex (CX) and striatum and increased protein carbonyls in hippocampus (HP) and CX and this was not attenuated by CLO treatment. In the total radical trapping antioxidant parameter assay there was a decrease in the HP total antioxidant potential induced by HAL and by treatment with HAL + CLO. Our findings demonstrated that the atypical antipsychotic CLO could not revert oxidative damage caused by HAL.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Agostinho FR,Jornada LK,Schröder N,Roesler R,Dal-Pizzol F,Quevedo Jdoi
10.1007/s11064-007-9311-3subject
Has Abstractpub_date
2007-08-01 00:00:00pages
1343-50issue
8eissn
0364-3190issn
1573-6903journal_volume
32pub_type
杂志文章abstract：:A set of synaptic membrane antigens has been investigated in a number of tissues by indirect immunofluorescence histochemistry, using an antiserum (SPM-I) raised against a purified synaptosomal plasma membrane fraction prepared from day-old chick forebrain. The antigens were found to be present in both the central and...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966022
更新日期：1977-02-01 00:00:00
abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964696
更新日期：1983-05-01 00:00:00
abstract：:Dual-specificity tyrosine-regulated kinase 2 (DYRK2), a protein kinase that phosphorylates its substrates on serine/threonine, is expressed in numerous human tumors, but little is known about its role in the pathophysiology of glioma. In this study, we made an effort to explore the expression and function in human gli...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2345-2
更新日期：2017-11-01 00:00:00
abstract：:The control and maintenance of the intracellular redox state is an essential task for cells and organisms. NAD(+) and NADH constitute a redox pair crucially involved in cellular metabolism as a cofactor for many dehydrogenases. In addition, NAD(+) is used as a substrate independent of its redox-carrier function by enz...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0760-y
更新日期：2012-11-01 00:00:00
abstract：:Cell densities and respiratory rates of astrocytes from neonatal rat brain grown in primary culture were determined after 20-30 days in vitro. Cells grown in flasks reached lower densities (microgram DNA/cm2) and higher protein:DNA ratios than cells grown in petri dishes. Respiratory rates were lower for cells grown i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964355
更新日期：1981-12-01 00:00:00
abstract：:The effects of vinpocetine on internal Na+ (Na(i)), cAMP accumulation, internal Ca2+ (Ca(i)) and excitatory amino acid neurotransmitters release, under resting and under depolarized conditions, was investigated in rat striatum synaptosomes. Veratridine (20 microM) or high K+ (30 mM) were used as depolarizing agents. R...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021164418478
更新日期：1999-12-01 00:00:00
abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-012-0906-y
更新日期：2013-06-01 00:00:00
abstract：:ESR spin trapping technique was used to detect and analyze free radical formation. When 6-hydroxydopamine (6-OHDA) was incubated alone or in the presence of a free radical generating system (H2O2 and FeSO4), hydroxyl free radicals were observed in a concentration-dependent manner. Glutathione was found to be the most ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965833
更新日期：1991-01-01 00:00:00
abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964981
更新日期：1985-10-01 00:00:00
abstract：:Bilateral lesion of the nucleus basalis with ibotenic acid infusions in young and aged rats results in the degeneration of cholinergic neurons which innervate the cortex. As expected, high-affinity uptake of choline was decreased in the frontal cortex subsequent to the lesion. Twenty one days after surgery there was a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00974576
更新日期：1992-04-01 00:00:00
abstract：:Rabbits sensitized with whole nervous tissue or myelin basic protein (MBP) plus adjuvant and developing experimental allergic encephalomyelitis (EAE) were studied for the presence of oligoclonal immunoglobulin (Ig) bands in spinal fluid and serum. Samples obtained prior to sensitization and at the time of sacrifice we...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963909
更新日期：1981-01-01 00:00:00
abstract：:The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and G...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964170
更新日期：1984-02-01 00:00:00
abstract：:The aim of this study was to explore effects of hypoxia, glucose deprivation (HGD) and recovery on expression and activities of equilibrative nucleoside transporters (rENT) and concentrative nucleoside transporters (rCNT) in rat astrocytes in primary culture. Amounts of cellular ATP in the control group (CG, 5% CO(2) ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0203-6
更新日期：2010-09-01 00:00:00
abstract：:In the present work we investigated the in vitro effect of the branched-chain amino acids (BCAA) accumulating in maple syrup urine disease (MSUD) on some parameters of energy metabolism in cerebral cortex of rats. 14CO2 production from [1-14C]acetate, [1-5-14C]citrate and [U-14C]glucose, as well as glucose uptake by t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9423-9
更新日期：2008-01-01 00:00:00
abstract：:A rapid and specific method for assaying 4-aminobutyrate-2-oxoglutarate aminotransferase was developed. The method was based on the selectivity of ion exchange resin and the speed of vacuum filtration. With this new method, the aminotransferase activity in various tissues has been determined as follows: brain, 10.2; s...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964061
更新日期：1978-04-01 00:00:00
abstract：:The folate cycle, which has a close correlation with nucleic acid synthesis as well as with sulfur amino acid metabolism, may have some bearing on the pathogenesis of amyotrophic lateral sclerosis. The folate cycle hypothesis offers a unified explanation of the reduction of RNA and the elevation of taurine in nervous ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963985
更新日期：1984-03-01 00:00:00
abstract：:Several amine oxidases are involved in the metabolism of the natural polyamines putrescine, spermidine, and spermine, and play a role in the regulation of intracellular concentrations, and the elimination of these amines. Since the products of the amine oxidase-catalyzed reactions -- hydrogen peroxide and aminoaldehyd...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007508008731
更新日期：2000-04-01 00:00:00
abstract：:The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967255
更新日期：1993-04-01 00:00:00
abstract：:Metabotropic glutamate receptors (mGluR) play a role in synaptic transmission, neuronal modulation and plasticity but their action in epileptic activity is still controversial. On the other hand adenosine acts as a neuromodulator with endogenous anticonvulsive properties. Since cerebellum from epileptic patients has s...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9275-8
更新日期：2007-07-01 00:00:00
abstract：:Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0327-8
更新日期：2011-02-01 00:00:00
abstract：:Ethylcholine mustard aziridinium ion (ECMA) was infused intracerebroventricularly (icv) to rats followed by measurement of two markers of presynaptic cholinergic neurons, choline acetyltransferase (ChAT) activity and high affinity choline transport (HAChT), in the hippocampus and cortex. Bilateral icv administration o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971589
更新日期：1988-08-01 00:00:00
abstract：:The calcium-activated phosphodiesteratic hydrolysis of 32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965878
更新日期：1985-08-01 00:00:00
abstract：:This study examined the relationship between the distance of axotomy and the death of injured retinal ganglion cells (RGCs) in adult hamsters and the relationship of cytochrome c and caspase-3 on the death pathway of RGCs. The left optic nerve (ON) of adult hamsters was transected either at 1 or 3 mm away from the opt...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-6889-6
更新日期：2004-11-01 00:00:00
abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007632326953
更新日期：2000-11-01 00:00:00
abstract：:Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before. In this study, we investigated the effect of TC on kainic acid-induced seizure activity ca...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1474-0
更新日期：2015-01-01 00:00:00
abstract：:Rhesus macaque monkey brain microvessel endothelial cells (BMECs) were isolated and grown in culture in an effort to establish an appropriate primate in vitro model of the endothelial component of the blood-brain barrier. The presence of Factor VIII antigen, alkaline phosphatase, gamma-glutamyl transpeptidase, lactate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967320
更新日期：1994-04-01 00:00:00
abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007696112956
更新日期：2000-10-01 00:00:00
abstract：:The aim of present study was to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on lipid peroxidation in experimental brain ischemia-reperfusion in rats. Present study was performed on the 34 male Wistar-albino rats, weigth 350-400 g. Experiment groups were designed as 1-Sham; 2-Ischemia-reperfusion; animal we...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1889-x
更新日期：2016-07-01 00:00:00
abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532309
更新日期：1996-07-01 00:00:00
abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1282-6
更新日期：2014-06-01 00:00:00
