Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities.

abstract：:SENP3 (SUMO-specific proteases 3), a member of the small ubiquitin-like modifier specific protease family, was identified as a molecule that deconjugates SUMOylation of modified protein substrates and functions as an isopeptidase by disrupting SUMO homeostasis to facilitate cancer development and progression. However,...

journal_title：Neurochemical research

authors： Wei H,Teng H,Huan W,Zhang S,Fu H,Chen F,Wang J,Wu C,Zhao J

更新日期：2012-12-01 00:00:00

abstract：:Transgenic therapy for central neuralgia faces the problems of low expression and weak targeting and affects superficial but not deep neurons. In this study, we generated a lentivirus vector with human preproenkephalin gene (hPPE) expression driven by the transcriptional amplification strategy system (TAS) and establi...

journal_title：Neurochemical research

authors： Yang J,Zhang L,Xie P,Pan M,Ma G

更新日期：2020-09-01 00:00:00

abstract：:Leucine is rapidly metabolized in astroglial primary cultures. Therefore, it is considered as valuable fuel in brain energy metabolism. Only few of the leucine metabolites generated and released by astroglial cells have been identified. Therefore, a more detailed study was performed analyzing by NMR techniques the 13C...

journal_title：Neurochemical research

authors： Bixel MG,Engelmann J,Willker W,Hamprecht B,Leibfritz D

更新日期：2004-11-01 00:00:00

abstract：:The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the phar...

journal_title：Neurochemical research

authors： Roques BP,Noble F

更新日期：1996-11-01 00:00:00

abstract：:In the present work we investigated the in vitro effect of the branched-chain amino acids (BCAA) accumulating in maple syrup urine disease (MSUD) on some parameters of energy metabolism in cerebral cortex of rats. 14CO2 production from [1-14C]acetate, [1-5-14C]citrate and [U-14C]glucose, as well as glucose uptake by t...

journal_title：Neurochemical research

authors： Ribeiro CA,Sgaravatti AM,Rosa RB,Schuck PF,Grando V,Schmidt AL,Ferreira GC,Perry ML,Dutra-Filho CS,Wajner M

更新日期：2008-01-01 00:00:00

abstract：:Serotonin uptake and metabolism was studied in ependymal primary cultures. Serotonin uptake was facilitated by two different systems, one of which was the neuronal serotonin transporter SERT, exhibiting a Vmax value of 3.8+/-0.1 pmol x min(-1) x (mg protein)(-1) and an apparent Michaelis-Menten constant of 0.41+/-0.03...

journal_title：Neurochemical research

authors： Verleysdonk S,Hamprecht B,Rapp M,Wellard J

更新日期：2004-09-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) and Schwann cells (SCs) are closely-related cell types with regeneration-promoting properties. Comparative gene expression analysis is particularly relevant since it may explain cell type-specific effects and guide the use of each cell type into special clinical applications. In the ...

journal_title：Neurochemical research

authors： Omar M,Hansmann F,Kreutzer R,Kreutzer M,Brandes G,Wewetzer K

更新日期：2013-05-01 00:00:00

abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...

journal_title：Neurochemical research

authors： Olianas MC,Onali P

更新日期：1990-11-01 00:00:00

abstract：:Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...

journal_title：Neurochemical research

authors： Kennedy SH,Davis BA,Brown GM,Ford CG,d'Souza J

更新日期：1993-12-01 00:00:00

abstract：:The characteristics of endogenous Ca2+/calmodulin (CaM)- and Ca2+/phosphatidylserine (PS)-stimulated phosphorylated proteins in the striatum of rat were partially determined and compared in this study. The Ca2+/CaM-dependent phosphoproteins were associated with serine and threonine residues. The sensitivity of these p...

journal_title：Neurochemical research

authors： Lau YS

更新日期：1990-03-01 00:00:00

abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...

journal_title：Neurochemical research

authors： Krumins SA,Lutz RA,Costa T,Rodbard D

更新日期：1986-06-01 00:00:00

abstract：:Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...

journal_title：Neurochemical research

authors： Liu B,Gu Y,Xiao H,Lei X,Liang W,Zhang J

更新日期：2015-04-01 00:00:00

abstract：:Metabolic modeling of dynamic (13)C labeling curves during infusion of (13)C-labeled substrates allows quantitative measurements of metabolic rates in vivo. However metabolic modeling studies performed in the brain to date have only modeled time courses of total isotopic enrichment at individual carbon positions (posi...

journal_title：Neurochemical research

authors： Shestov AA,Valette J,Deelchand DK,Uğurbil K,Henry PG

更新日期：2012-11-01 00:00:00

abstract：:Hypoxia-induced oxidative stress is one of the major hallmark reasons underlying brain dysfunction. In the present manuscript, we have used CoCl2-induced hypoxic mice to investigate alterations in the activities of chief antioxidative stress enzymes- superoxide dismutase (SOD) and catalase (CAT) and expression of thei...

journal_title：Neurochemical research

authors： Rani A,Prasad S

更新日期：2014-09-01 00:00:00

abstract：:Several lines of evidence indicate that ATP may play an important role in Long-Term Potentiation. In this investigation we evaluated the effect of a memory task (step-down inhibitory avoidance) on the synaptosomal ecto-enzymes (ATP diphosphohydrolase and 5'-nucleotidase) involved in the degradation of ATP to adenosine...

journal_title：Neurochemical research

authors： Bonan CD,Dias MM,Battastini AM,Dias RD,Sarkis JJ

更新日期：1998-07-01 00:00:00

abstract：:The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...

journal_title：Neurochemical research

authors： Nakajima T

更新日期：1996-02-01 00:00:00

abstract：:The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the ...

journal_title：Neurochemical research

authors： Zhang J,Liu Z,Pei Y,Yang W,Xie C,Long S

更新日期：2020-09-01 00:00:00

abstract：:The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....

journal_title：Neurochemical research

authors： Mishra OP,Delivoria-Papadopoulos M

更新日期：1992-12-01 00:00:00

abstract：:Cathepsin B (EC 3.4.22.1) was purified 746-fold with a 21% recovery from bovine brain by autolysis, fractional precipitation with acetone, carboxy-methyl-Sephadex chromatography, affinity chromatography on a cystamine containing column and gel filtration chromatography. The purified cathepsin B eluted on gel filtratio...

journal_title：Neurochemical research

authors： Bradley JD,Whitaker JN

更新日期：1986-06-01 00:00:00

abstract：:Several amine oxidases are involved in the metabolism of the natural polyamines putrescine, spermidine, and spermine, and play a role in the regulation of intracellular concentrations, and the elimination of these amines. Since the products of the amine oxidase-catalyzed reactions -- hydrogen peroxide and aminoaldehyd...

journal_title：Neurochemical research

authors： Seiler N

更新日期：2000-04-01 00:00:00

abstract：:Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-old rats and lowest in adults, while the density of muscarinic binding...

journal_title：Neurochemical research

authors： Balduini W,Costa LG,Murphy SD

更新日期：1990-01-01 00:00:00

abstract：:The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...

journal_title：Neurochemical research

authors： Kar F,Hacioglu C,Uslu S,Kanbak G

更新日期：2019-08-01 00:00:00

abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...

journal_title：Neurochemical research

authors： Ono K

更新日期：2017-12-01 00:00:00

abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...

journal_title：Neurochemical research

authors： Brockerhoff H,Wisniewski HM,Lipton LC,Deshmukh DS

更新日期：1980-06-01 00:00:00

abstract：:Single prolonged stress (SPS) rats is a rodent model of post traumatic stress disorder (PTSD). Abnormal hippocampal morphology and function were found in the PTSD patients. Our previous study has shown that SPS induce loss of hippocampal neurons. But the effects of SPS on glial cells in the hippocampus have not been e...

journal_title：Neurochemical research

authors： Han F,Xiao B,Wen L

更新日期：2015-05-01 00:00:00

abstract：:5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GC-MS of the ditrifluoromethylbenzoyl...

journal_title：Neurochemical research

authors： Andrew R,Watson DG,Best SA,Midgley JM,Wenlong H,Petty RK

更新日期：1993-11-01 00:00:00

abstract：:The 12/15-lipoxygenase(s) (LOX), poly(ADP-ribose) polymerase (PARP-1) activity and mitochondrial apoptosis inducing factor (AIF) protein in the amyloid β (Aβ) toxicity were investigated in PC12 cells that express either wild-type (APPwt) or double Swedish mutation (APPsw) forms of human Aβ precursor protein. Different...

journal_title：Neurochemical research

authors： Strosznajder JB,Cieslik M,Cakala M,Jesko H,Eckert A,Strosznajder RP

更新日期：2011-05-01 00:00:00

abstract：:The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacrylamide gel electrophoresis and computerized quantitation. Experiments were done on three groups of eggs: control group was incubated in the dark; simultan...

journal_title：Neurochemical research

authors： Zhang J,Huether G,Neuhoff V

更新日期：1987-04-01 00:00:00

abstract：:C-6 glial cells were studied in culture with respect to morphological and biochemical changes under several experimental conditions. Doubling time was 33 hr for cells plated at either 0.5 or 1.0×10(6) cells per flask. Markedly reduced cell growth and astrocyte-like appearance were observed following dibutyryl cyclic A...

journal_title：Neurochemical research

authors： Vernadakis A,Nidess R

更新日期：1976-08-01 00:00:00

abstract：:Brain development is a highly orchestrated complex process. The developing brain utilizes many substrates including glucose, ketone bodies, lactate, fatty acids and amino acids for energy, cell division and the biosynthesis of nucleotides, proteins and lipids. Metabolism is crucial to provide energy for all cellular p...

journal_title：Neurochemical research

authors： McKenna MC,Scafidi S,Robertson CL

更新日期：2015-12-01 00:00:00