Abstract：
:C-6 glial cells were studied in culture with respect to morphological and biochemical changes under several experimental conditions. Doubling time was 33 hr for cells plated at either 0.5 or 1.0×10(6) cells per flask. Markedly reduced cell growth and astrocyte-like appearance were observed following dibutyryl cyclic AMP (DBcAMP) treatment. An inverse relationship between cell density and DNA, RNA, and protein content per cell was observed. AChE and BuChE activities were also inversely related to cell density, and treatment with DBcAMP increased enzyme activity, but did not alter the cell density relationship. Uptake of(3)H-norepinephrine also decreased with increasing cell density. In DBcAMP-treated cells,(3)H-NE uptake was markedly lower than in nontreated controls, and cortisol treatment decreased the uptake of(3)H-NE in DBcAMP-treated cells further still. We interpreted the foregoing changes to indicate that cellular activity is cell density-dependent.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Vernadakis A,Nidess Rdoi
10.1007/BF00966230subject
Has Abstractpub_date
1976-08-01 00:00:00pages
385-402issue
4eissn
0364-3190issn
1573-6903journal_volume
1pub_type
杂志文章abstract：:Paclitaxel (PTX) is an antineoplastic agent commonly used in the treatment of solid tumors and is known to cause dose-limiting peripheral neurotoxicity. This study was performed to evaluate the protective effect of curcumin (CUR) against PTX-induced spinal cord and sciatic nerve injuries in rats. The rats were adminis...
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