Abstract:
:The effects of carbachol (CCh) on the frequency (f) of the miniature endplate potentials were tested at temperatures between 5 and 30 degrees C. Higher CCh concentrations, 1 x 10(-5) and 5 x 10(-6) M, reduced the f to 60% and the temperature dependence was negligible. However, an inverse temperature dependence was found when low concentrations 3 x 10(-7) and 6 x 10(-7) M were applied. The depression of f was 40-50% in 5-10 degrees C but only 10-20% of the control in the 25 and 30 degrees C. During application of CCh, the new steady of f was reached at temperatures between 5 and 30 degrees C within 17-20 min (Q10 = 1.07). Much greater temperature dependence of recovery was observed during washing out CCh (Q10 = 1.6). The temperature-independence of the steady state effects of CCh, good agreement with Langmuir adsorption-desorption theory and non-steady kinetics indicate that physical rather than receptor-mediated events are responsible for the depression of f.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Strunsky EG,Borisover MD,Nikolsky EE,Vyskocil Fdoi
10.1023/a:1012372115058keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
891-7issue
8-9eissn
0364-3190issn
1573-6903journal_volume
26pub_type
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