Abstract：
:MicroRNAs (miRNAs), an abundant class of small noncoding RNA molecules, which regulate gene expression by functioning as post-transcriptional regulatory factors, have been identified as key components of traumatic brain injury (TBI) progression. MicroRNA-21 (miR-21) is a recently identified typical miRNA that is involved in the signaling pathways of inflammation, neuronal apoptosis, reactive gliosis, disruption of blood brain barrier, angiogenesis and recovery process induced by physical exercises in TBI. Hence, miR-21 is now considered as a potential therapeutic target of TBI. We review the correlative literature and research progress regarding the roles of miR-21 in TBI in this article.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Ji W,Jiao J,Cheng C,Shao Jdoi
10.1007/s11064-018-2602-zsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
1863-1868issue
10eissn
0364-3190issn
1573-6903pii
10.1007/s11064-018-2602-zjournal_volume
43pub_type
杂志文章,评审abstract：:Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate tha...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-019-02753-0
更新日期：2020-03-01 00:00:00
abstract：:This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9661-5
更新日期：2008-09-01 00:00:00
abstract：:The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1282-6
更新日期：2014-06-01 00:00:00
abstract：:Cortical spreading depression (CSD) enhances ischemic tolerance to temporary focal ischemia. Although this effect most likely requires the expression or activation of neuroprotective factors, their identity remains relatively unknown. One important factor involved in neuroprotection is adenosine monophosphate-dependen...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1447-3
更新日期：2014-12-01 00:00:00
abstract：:The effect of ageing and the relationships between the catalytic properties of enzymes linked to Krebs' cycle, electron transfer chain, glutamate and aminoacid metabolism of cerebral cortex, a functional area very sensitive to both age and ischemia, were studied on mitochondria of adult and aged rats, after complete i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0004-y
更新日期：2009-12-01 00:00:00
abstract：: ...
journal_title：Neurochemical research
pub_type： 传,社论,历史文章
doi：10.1007/s11064-018-02702-3
更新日期：2019-01-01 00:00:00
abstract：:Leucine is rapidly metabolized in astroglial primary cultures. Therefore, it is considered as valuable fuel in brain energy metabolism. Only few of the leucine metabolites generated and released by astroglial cells have been identified. Therefore, a more detailed study was performed analyzing by NMR techniques the 13C...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-6879-8
更新日期：2004-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00978372
更新日期：1993-11-01 00:00:00
abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022869222652
更新日期：2003-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0649-1
更新日期：2012-03-01 00:00:00
abstract：:A number of axonal proteins display changes in phosphorylation during goldfish optic nerve regeneration (Larrivee and Grafstein, 1989). (1) To determine whether the phosphorylation of these proteins was closely linked to their synthesis in the retinal ganglion cell body, cycloheximide was injected intraocularly into g...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965906
更新日期：1990-09-01 00:00:00
abstract：:Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we cha...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9434-6
更新日期：2008-01-01 00:00:00
abstract：:Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). In the present study we investigated temporal and cellular expression pattern of this channel in the lumbar part of spinal cords of animals with experimental autoimmune encephalomyelitis (EAE), animal mod...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2509-8
更新日期：2018-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973747
更新日期：1990-06-01 00:00:00
abstract：:Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0639-3
更新日期：2012-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971579
更新日期：1994-03-01 00:00:00
abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969632
更新日期：1989-02-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01474679
更新日期：1993-02-01 00:00:00
abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965208
更新日期：1986-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03078-z
更新日期：2020-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0633-9
更新日期：2012-03-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964552
更新日期：1983-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022466624223
更新日期：1997-08-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2486-y
更新日期：2018-04-01 00:00:00
abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1024280429036
更新日期：2003-08-01 00:00:00
abstract：:The 7S NGF complex from the male mouse submaxillary gland consists of the alpha, gamma, and beta subunits in the ratio alpha 2 gamma 2 beta. The beta (NGF) subunit contains all the known biolocial activity of 7S NGF. The alpha and gamma subunits are both members of glandular kallikrein gene family, yet only gamma subu...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965545
更新日期：1991-06-01 00:00:00
abstract：:The features of neuronal damage induced by the mitochondrial toxin NaN(3) were investigated in rat primary cortical neuron cultures. Cell viability (MTT colorimetric determination) and transmembrane mitochondrial potential (J-C1 fluorescence) were concentration-dependently reduced 24 h after NaN(3); neither nuclear fr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9852-0
更新日期：2009-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00993245
更新日期：1987-04-01 00:00:00
abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965201
更新日期：1983-08-01 00:00:00
abstract：:Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968559
更新日期：1990-08-01 00:00:00
