Abstract：
:Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum (CS) under these conditions. GABA accumulation rate (measured with ethanolamine-O-sulfate, an inhibitor of GABA-transaminase) was also increased in both H and CS of rats exposed to LET for 2 h. Unlike after a single exposure, the repeated exposure (2 h/day) for 7, 15, and 30 consecutive days did not change the hypothalamic GABA metabolism. No change in GABA metabolism was observed in CS when rats were repeatedly exposed to LET for 7 consecutive days. Prolongation of repeated exposure to LET (2 h/day) for 15 and 30 consecutive days decreased the striatal GABA level and increased the activity of GABA-transaminase, although GAD activity was not altered under these conditions. These results suggest that single exposure to LET accelerates GABA synthesis and may reduce the GABAergic activity in both H and CS; whereas repeated exposure to LET for 15 or 30 consecutive days enhances GABAergic activity with the stimulation of GABA utilization only in CS without affecting its synthesizing process. Thus, it may be suggested that the hypothalamic and striatal GABA system may play a characteristic role in response to short- and long-term exposure to LET.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Biswas S,Poddar MKdoi
10.1007/BF00968559subject
Has Abstractpub_date
1990-08-01 00:00:00pages
815-20issue
8eissn
0364-3190issn
1573-6903journal_volume
15pub_type
杂志文章abstract：:Malignant peripheral nerve sheath (MPNST) cell lines derived from patients with neurofibromatosis type 1 (NF!) were found to have basal cAMP levels which are two-fold higher than cAMP levels in normal human adult Schwann cells (nHSC). PCR analysis also revealed that normal adult human Schwann cells express mRNA for ty...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0433-2
更新日期：2011-09-01 00:00:00
abstract：:The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit co...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022826220469
更新日期：2003-05-01 00:00:00
abstract：:Chemokines are small secreted proteins that are essential for the recruitment and activation of specific leukocyte subsets at sites of inflammation and for the development and homeostasis of lymphoid and nonlymphoid tissues. During the past decade, chemokines and their receptors have also emerged as key signaling mole...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/b:nere.0000021246.96864.89
更新日期：2004-05-01 00:00:00
abstract：:Exposure of rat pheochromocytoma PC12 cells to 0.1 mM 6-aminonicotinamide (6AN) for 24 hours resulted in a 500-fold increase in 6-phosphogluconate indicating active metabolism of glucose via the oxidative enzymes of the pentose phosphate pathway. Amounts of 6-phosphogluconate that accumulated in 6AN-treated cells at 2...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01000236
更新日期：1987-06-01 00:00:00
abstract：:In an effort to develop an animal model of hyperpipecolatemia, the uptake of pipecolic acid (PA) in the brain and changes of PA levels in serum following administration of D,L-PA were studied in the mouse using a new sensitive HPLC-EC method. Following i.p. injections (250 mg/kg) to adult male mice, the brain concentr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964981
更新日期：1985-10-01 00:00:00
abstract：:Oxidative stress is a long-hypothesized cause of diverse neurological and psychiatric disorders but the pathways by which physiological redox perturbations may detour healthy brain development and aging are unknown. We reported recently (Foley et al., Neurochem Res 39:2030-2039, 2014) that two-electron oxidations, to ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1991-0
更新日期：2016-10-01 00:00:00
abstract：:Disruptive effects of calcium upon neurofilaments and glial filaments were studied in white matter of rat optic nerve and spinal cord and in rat peripheral nerve. Filament ultrastructure and tissue protein composition were compared following a calcium influx into excised tissues. A calcium influx was induced by freeze...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964040
更新日期：1981-03-01 00:00:00
abstract：:Consumption of fifteen percent alcohol, during gestation did not cause any decrease in the total calorie or fluid intake of the rats maintained on normal dietary regimen. However, the alcohol consumption by gestating mothers resulted in a decreased contents of both DNA and protein in the CNS of the in utero alcohol ex...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965614
更新日期：1989-11-01 00:00:00
abstract：:It is well known that the principal biomolecules involved in Alzheimer's disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Aβ42). ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1400-5
更新日期：2014-11-01 00:00:00
abstract：:Cell densities and respiratory rates of astrocytes from neonatal rat brain grown in primary culture were determined after 20-30 days in vitro. Cells grown in flasks reached lower densities (microgram DNA/cm2) and higher protein:DNA ratios than cells grown in petri dishes. Respiratory rates were lower for cells grown i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964355
更新日期：1981-12-01 00:00:00
abstract：:The nerve agent VX has a variable and delayed absorption through the skin, which may have implications for treatment regimens. In the present study, central and peripheral effects of percutaneous VX intoxication were investigated in hairless guinea pigs. Although onset times of clinical signs varied considerably, the ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9508-5
更新日期：2008-02-01 00:00:00
abstract：:Numerous studies have demonstrated that the Acetyl Coenzyme A-dependent arylamine NAT enzyme exist in many tissues of experimental animals including humans, and that NAT has been shown to be exist in mouse brain tissue. Increased NAT activity levels are associated with increased sensitivity to the mutagenic effects of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1007632326953
更新日期：2000-11-01 00:00:00
abstract：:During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9506-7
更新日期：2008-04-01 00:00:00
abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-9032-4
更新日期：2006-03-01 00:00:00
abstract：:Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1609-y
更新日期：2017-01-01 00:00:00
abstract：:The developmental profiles of acetylcholinesterase and choline acetyltransferase in chick optic tectum and retina cell aggregates, over a 30-day period, have been determined and compared with the corresponding developmental curves obtained in vivo. Both acetylcholinesterase and choline acetyltransferase activities in ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965466
更新日期：1977-08-01 00:00:00
abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF01101712
更新日期：1990-11-01 00:00:00
abstract：:The effect of isoproterenol, norepinephrine, dopamine, and serotonin on the accumulation of adenosine 3',5'-monophosphate (cAMP) was studied in homogeneous neuronal cultures from 8-day chick embryo hemispheres. Among the catecholamines, isoproterenol had a more pronounced effect on the accumulation of cAMP. Norepineph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966167
更新日期：1980-10-01 00:00:00
abstract：:The objective of the present study was to investigate the effects of senescence on the binding characteristics of muscarinic receptors by using [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) as ligands in young (3 months), middle-age (10 months) and old (24 months) male Fischer 344 rats. M...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971637
更新日期：1988-12-01 00:00:00
abstract：:Due to the biological importance of sodium and its relative scarcity within many natural environments, 'salt appetite' has evolved whereby dietary salt is highly sought after and palatable when tasted. In addition to peripheral responses, salt depletion is detected within the brain via circumventricular organs and 11β...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2336-3
更新日期：2018-01-01 00:00:00
abstract：:During evolution, living organisms develop a specialized apparatus called nociceptors to sense their environment and avoid hazardous situations. Intense stimulation of high threshold C- and Adelta-fibers of nociceptive primary sensory neurons will elicit pain, which is acute and protective under normal conditions. A f...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-008-9711-z
更新日期：2008-10-01 00:00:00
abstract：:Chronic thiamine deprivation in the rat leads to ataxia, loss of righting reflex and neuropathological damage to lateral vestibular nucleus. Before onset of neurological symptoms, transketolase (TK) activities were found to be selectively reduced by 25% in lateral vestibular nucleus and surrounding pons. Further progr...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00972141
更新日期：1987-03-01 00:00:00
abstract：:The binding of [3H]ethylketocyclazocine ([3H]EKC) under the suppression of mu and delta sites in the brain of EL mice (seizure-susceptible) was examined to determine the relationship between seizures and the dynorphinergic system. The density of kappa-opioid receptors in the cerebrum of adult EL mice during interictal...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022424707543
更新日期：1998-02-01 00:00:00
abstract：:Adult neural stem cells can be isolated from various regions of the rat brain and seem to have multilineage differentiation potential. In this study, we investigated the hypothesis that global protein expression of adult neural stem cells isolated from rat hippocampus is changed during in vitro differentiation. After ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000023600.25994.11
更新日期：2004-06-01 00:00:00
abstract：:Aging is accompanied by the loss of memory and cognitive functions. The extracellular signal-regulated kinase (ERK) pathway has been shown to play an essential role in synaptic plasticity and memory. Although a reduction in basal ERK1/2 activity has been found in the cerebral cortex in aged rats, changes in ERK1/2 mRN...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1024948532633
更新日期：2003-09-01 00:00:00
abstract：:NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02533102
更新日期：1996-12-01 00:00:00
abstract：:Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...
journal_title：Neurochemical research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00975048
更新日期：1993-12-01 00:00:00
abstract：:Endogenous and xenobiotic sulphur-containing convulsant and non-convulsant compounds containing structural moieties of, or bearing a structural resemblance to, GABA and homocysteine were tested in binding studies for their potency in displacing the GABA-mimetic [3H]muscimol from specific, high-affinity sites (Kd = 3.6...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971006
更新日期：1987-07-01 00:00:00
abstract：:The anterograde axonal transport of choline-phosphoglycerides was studied in sciatic nerve motoneurons of adult (3-month-old) and aged (24-month-old) rats. After the spinal cord injection of [2-3H]glycerol, choline-phosphoglycerides; the major phospholipid class was transported along the nerve. The axonal transport ra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971365
更新日期：1987-01-01 00:00:00
abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0938-3
更新日期：2013-03-01 00:00:00
