Abstract：
:The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit collagenase, the amount of bleeding was measured using a hemoglobin assay developed in the present study and was compared with the morphologically determined hematoma volume. The blood amounts and hematoma volumes were significantly correlated, and the hematoma induced by 0.014-unit collagenase was adequate to detect ICH deterioration. In ICH induction using 0.014-unit collagenase, heparin enhanced the hematoma volume 3.4-fold over that seen in control ICH animals and the bleeding 7.6-fold. Data suggest that this sensitive hemoglobin assay is useful for ICH detection, and that a model with a small ICH induced with a low-dose collagenase should be used for evaluation of drugs that may affect ICH.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Terai K,Suzuki M,Sasamata M,Miyata Kdoi
10.1023/a:1022826220469keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
779-85issue
5eissn
0364-3190issn
1573-6903journal_volume
28pub_type
杂志文章abstract：:Pathophysiological concentrations of branched chain keto-acids (BCKAs), such as those that occur in maple syrup urine disease, inhibit oxygen consumption in liver homogenates and brain slices and the enzymatic activity of alpha-ketoglutarate- and pyruvate dehydrogenase complexes. Consistent with previous work, studies...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9291-3
更新日期：2007-04-01 00:00:00
abstract：:Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-9008-4
更新日期：2006-02-01 00:00:00
abstract：:Tyrosinemia type II, also known as Richner-Hanhart syndrome, is an autosomal recessive inborn error of metabolism caused by a deficiency of hepatic cytosolic tyrosine aminotransferase, and is associated with neurologic and development difficulties in numerous patients. Considering that the mechanisms underlying the ne...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1180-3
更新日期：2013-12-01 00:00:00
abstract：:NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02533102
更新日期：1996-12-01 00:00:00
abstract：:Natural products including those derived from plants, have over the years greatly contributed to the development of therapeutic drugs. Polygodial and drimanial are sesquiterpenes isolated from the bark of the plant Drymis Winteri (Winteraceae) that exhibit antinociceptive properties. Since peripheral glutamate present...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-9033-3
更新日期：2006-03-01 00:00:00
abstract：:The effect of isoproterenol, norepinephrine, dopamine, and serotonin on the accumulation of adenosine 3',5'-monophosphate (cAMP) was studied in homogeneous neuronal cultures from 8-day chick embryo hemispheres. Among the catecholamines, isoproterenol had a more pronounced effect on the accumulation of cAMP. Norepineph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966167
更新日期：1980-10-01 00:00:00
abstract：:The subcellular distribution of Ca2+/calmodulin-stimulated adenylate cyclase activity was studied in comparison with that of guanine nucleotide-stimulated cyclase activity. The distributions of these activities were similar among the crude fractions but differed among the purified subsynaptosomal fractions. The specif...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965018
更新日期：1986-03-01 00:00:00
abstract：:Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968406
更新日期：1992-12-01 00:00:00
abstract：:Exercise increases both the consumption of oxygen and the production of reactive species in biological tissues, and this is counterbalanced by antioxidant adaptations to regular physical training. When the intensity of exercise fluctuates between mild and moderate, it improves the status of reduction-oxidation balance...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1339-6
更新日期：2014-08-01 00:00:00
abstract：:The patterns of cholesterol content in chick brain and liver were studied during embryonic development and compared with the variations in the specific activities of mevalonate-activating enzymes during the same period. Total cholesterol content in both embryonic chick brain and liver increased during incubation. The ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964728
更新日期：1983-06-01 00:00:00
abstract：:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1025678510480
更新日期：2003-10-01 00:00:00
abstract：:The long-acting opiate antagonist naltrexone hydrochloride was administered by intraperitoneal injection, in a dose response protocol, to adult rats. The drug was used to observe effects of opiate receptor blockade on cells of the pituitary gland and adjacent hypothalamus. At higher drug doses (5 mg/kg or 10 mg/kg), n...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964168
更新日期：1984-02-01 00:00:00
abstract：:The effects of a number of drugs that deplete catecholamines or block their receptors were investigated on the levels of free amino acids and glutamate decarboxylase activity in rat striatum and substantia nigra, in an attempt to clarify the possible links between catecholamine and amino acid transmitter function. Whi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966009
更新日期：1977-10-01 00:00:00
abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9187-7
更新日期：2007-02-01 00:00:00
abstract：:We have previously showed that peptide neurotensin inhibits neuronal Na(+), K(+)-ATPase activity, an effect which involves high affinity neurotensin receptor. Nitric oxide (NO) acts as a neurotransmitter or as a neuromodulator when it is synthesized by neuronal nitric oxide synthase. Neurotensin effect on Na(+), K(+)-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0552-9
更新日期：2011-12-01 00:00:00
abstract：:Curcumin (diferuloyl), from the Indian spice turmeric, reduces oxidative damage and induces apoptosis. Utilizing DNA microarrays, we have demonstrated that a low (5 microM) dose of curcumin added to a mixture of astrocytes and oligodendrocytes (C6 rat glioma cells) in culture for 24 and 48 h significantly modulates ge...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9608-x
更新日期：2008-09-01 00:00:00
abstract：:Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2621-9
更新日期：2018-10-01 00:00:00
abstract：:The amyloid peptide (Abeta) deposited in Alzheimer's disease (AD) is generated by beta- and gamma-secretase processing of a larger integral membrane protein precursor (APP). Intramembrane processing of APP by gamma-secretase also yields an intracellular fragment, CTFgamma (a.k.a. AICD), which is highly conserved and i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-007-9449-z
更新日期：2007-12-01 00:00:00
abstract：:Glutamine synthetase (GS) from the chick brain was purified to apparent homogeneity by ammonium sulfate fractionation followed by affinity chromatography, electrofocusing and Sephadex G-150 chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate analysis in polyacrylamide gel. By sedimentati...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970934
更新日期：1987-11-01 00:00:00
abstract：:Ion fluxes in mammalian myelinated axons are restricted to the nodes of Ranvier, where, in particular, voltage-gated Na+ channels are clustered at a high density. The node of Ranvier is separated from the internode by two distinct domains of the axolemma, the paranode and the juxtaparanode. Each axonal domain is chara...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021608514646
更新日期：2003-01-01 00:00:00
abstract：:The mutual interactions and the effects of GABA on the saturable transport components of taurine and hypotaurine were investigated with mouse brain slices. The low-affinity taurine transport was competitively inhibited by both hypotaurine and GABA. Hypotaurine did not alter the kinetic parameters of high-affinity taur...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964995
更新日期：1983-11-01 00:00:00
abstract：:A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532395
更新日期：1996-10-01 00:00:00
abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969632
更新日期：1989-02-01 00:00:00
abstract：:In the present paper we describe the presence in avian CNS of an endogenous inhibitor of [3H]flunitrazepam binding. This compound was extracted from a synaptic membrane fraction isolated from chick optic lobe and brain using an exhaustive aqueous washing procedure, then purified by means of solid-phase extraction with...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020702823600
更新日期：1998-11-01 00:00:00
abstract：:We have synthesized the tertiary amines of pyridostigmine and neostigmine, 3-pyridinol dimethylcarbamate (norpyridostigmine) and 3-dimethylaminophenol dimethylcarbamate (norneostigmine) respectively, and we have tested their abilities to cross the blood-brain barrier and inhibit mouse brain AChE activity. The in vivo ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00973747
更新日期：1990-06-01 00:00:00
abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969627
更新日期：1989-02-01 00:00:00
abstract：:The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. In the first two experiments corticosterone significantl...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966670
更新日期：1992-03-01 00:00:00
abstract：:Altered neurogenesis has been reported in Alzheimer disease (AD), the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of β-amyloid (Aβ). Recent studies suggest that tau phosphorylation is essential for hippocampal neurogenesis, however, it is not known whether tau pho...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0316-y
更新日期：2011-02-01 00:00:00
abstract：:28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffeoyl triterpene with little information associated with its pharmacological target(s). To date no data is av...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03202-z
更新日期：2021-01-03 00:00:00
abstract：:Systemic inflammation is present in obesity and emerging evidence, primarily from studies using male rodents fed high-fat diets, suggests neuroimmune signaling also is involved. We investigated early changes in neuroimmune signaling during the weight gain that follows ovariectomy in rats. Ovariectomized (OVX) rats wer...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2596-6
更新日期：2018-09-01 00:00:00
