Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination.

abstract：:Spinal cord injury (SCI) is a functional impairment of the spinal cord caused by external forces, accompanied by limb movement disorders and permanent paralysis, which seriously lowers the life quality of SCI patients. Secondary injury caused by inflammation attenuated the therapeutic effects of SCI. Therefore, the ex...

journal_title：Neurochemical research

authors： Zhao L,Shen J,Jia K,Shi F,Hao Q,Gao F

更新日期：2021-01-13 00:00:00

abstract：:In order to obtain further evidence of putative neurotransmitters in primary sensory neurons and interneurons in the dorsal spinal cord, we have studied the effects of unilateral section of dorsal roots and unilateral occlusion of the dorsal spinal artery on cholinergic enzyme activity and on selected amino acid level...

journal_title：Neurochemical research

authors： Fujita K,Nagata Y

更新日期：1989-05-01 00:00:00

abstract：:Kv1.3 is a voltage gated potassium channel that has been implicated in pathophysiology of multiple sclerosis (MS). In the present study we investigated temporal and cellular expression pattern of this channel in the lumbar part of spinal cords of animals with experimental autoimmune encephalomyelitis (EAE), animal mod...

journal_title：Neurochemical research

authors： Bozic I,Tesovic K,Laketa D,Adzic M,Jakovljevic M,Bjelobaba I,Savic D,Nedeljkovic N,Pekovic S,Lavrnja I

更新日期：2018-05-01 00:00:00

abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...

journal_title：Neurochemical research

authors： Giacobini E

更新日期：2003-04-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease, with genetics and environment contributing to the disease onset. The limited pathological cognize of the disease restrained the approaches to improve the clinical treatment. Recently, studies showed that endoplasmic reticulum (ER) stress played an important role...

journal_title：Neurochemical research

authors： Ning B,Deng M,Zhang Q,Wang N,Fang Y

更新日期：2016-08-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we i...

journal_title：Neurochemical research

authors： Watanabe R,Kurose T,Morishige Y,Fujimori K

更新日期：2018-02-01 00:00:00

abstract：:The expression and localization of syntaxin isoforms 1A and 1B in adrenergic and noradrenergic chromaffin cells were examined by both immunoblot analysis and confocal immunofluorescence microscopy. Syntaxin 1A was found in higher levels in noradrenergic cells, whereas syntaxin 1B was similarly expressed in most noradr...

journal_title：Neurochemical research

authors： Baltazar G,Carvalho AP,Duarte EP

更新日期：2003-10-01 00:00:00

abstract：:The monoclonal antibody 14E immunocytochemically stains the nuclear membrane of oligodendrocytes but not myelin in tissue sections of adult normal human white matter. The nuclear membranes of Schwann cells in human peripheral nerve and cerebellar Bergmann glia were also visualized with this antibody. In actively demye...

journal_title：Neurochemical research

authors： Newcombe J,Naik N,Cuzner ML

更新日期：1992-09-01 00:00:00

abstract：:Factors secreted by C6 glioma cells which induce electrical resistances across endothelial monolayers in an in vitro blood-brain barrier model have been partially characterised for the first time. These transendothelial electrical resistances (TEERs) were only evident when cell-free conditioned medium derived from C6 ...

journal_title：Neurochemical research

authors： Ramsohoye PV,Fritz IB

更新日期：1998-12-01 00:00:00

abstract：:Social isolation during early development is one of the most potent stressors that can cause alterations in the processes of brain maturation, leading to behavioral and neurochemical changes that may persist to adulthood. Exposure to palatable diets during development can also affect neural circuits with long-term con...

journal_title：Neurochemical research

authors： Arcego DM,Krolow R,Lampert C,Noschang C,Pettenuzzo LF,Marcolin ML,Toniazzo AP,Dalmaz C

更新日期：2013-09-01 00:00:00

abstract：: ...

journal_title：Neurochemical research

authors： Choi IY,Schousboe A

更新日期：2019-01-01 00:00:00

abstract：:Glutamine synthetase (GS) is the major glutamine-forming enzyme of vertebrates and is accepted to be a marker of astroglial cells. Maturation of astroglial cells is characterized by an increase of GS activity, and the regulation of this enzyme is the topic of many publications. Because of the fundamental role of the G...

journal_title：Neurochemical research

authors： Haghighat N

更新日期：2005-05-01 00:00:00

abstract：:Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutritio...

journal_title：Neurochemical research

authors： Perry G,Nunomura A,Raina AK,Aliev G,Siedlak SL,Harris PL,Casadesus G,Petersen RB,Bligh-Glover W,Balraj E,Petot GJ,Smith MA

更新日期：2003-10-01 00:00:00

abstract：:Astrocytes have been considered to be transformed from radial glial cells that appear at early stage of development and play a scaffold-role for neuronal cell migration. Recent studies indicate that neuroepithelial cells in the spinal cord also give rise to astrocytes. However, the mode of astroglial generation and mi...

journal_title：Neurochemical research

authors： Seo JH,Chang JH,Song SH,Lee HN,Jeon GS,Kim DW,Chung CK,Cho SS

更新日期：2008-07-01 00:00:00

abstract：:Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...

journal_title：Neurochemical research

authors： Ferchmin PA,Pérez D,Cuadrado BL,Carrasco M,Martins AH,Eterović VA

更新日期：2015-10-01 00:00:00

abstract：:Crayfish glutamic acid decarboxylase (GAD), like the homologous enzymes from other species, is inhibited by carbonyl-trapping agents (e.g. aminooxyacetic acid; AOAA) and sulfhydryl reagents (e.g. 5,5'-dithiobis-(2-nitrobenzoic acid); DTNB). It also is inhibited by the product GABA, many anions (e.g. SCN- and Cl-), and...

journal_title：Neurochemical research

authors： Grossfeld RM,Yancey SW,Baxter CF

更新日期：1984-07-01 00:00:00

abstract：:Umbilical cord blood-derived marrow stromal cells (UCB-MSCs) with high proliferation capacity and immunomodulatory properties are considered to be a good candidate for cell-based therapies. But until now, little work has been focused on the differentiation of UCB-MSCs. In this work, UCB-MSCs were demonstrated to be ne...

journal_title：Neurochemical research

authors： Zeng Y,Rong M,Liu Y,Liu J,Lu M,Tao X,Li Z,Chen X,Yang K,Li C,Liu Z

更新日期：2013-12-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by α-synuclein toxicity, which is also associated with the higher le...

journal_title：Neurochemical research

authors： Melo TQ,Copray SJCVM,Ferrari MFR

更新日期：2018-12-01 00:00:00

abstract：:The effects of phenylalanine (PHE) and its deaminated metabolites phenylpyruvate (PHP), phenyllactate (PHL) and phenylacetate (PHA) on sodium and potassium activated adenosinetriphosphatase (Na+,K+-ATPase) in synaptosomes from rat brain were investigated. At very low concentrations (5-10 microM). PHE, PHL and PHA inhi...

journal_title：Neurochemical research

authors： Dwivedy AK,Shah SN

更新日期：1982-06-01 00:00:00

abstract：:We have synthesized the tertiary amines of pyridostigmine and neostigmine, 3-pyridinol dimethylcarbamate (norpyridostigmine) and 3-dimethylaminophenol dimethylcarbamate (norneostigmine) respectively, and we have tested their abilities to cross the blood-brain barrier and inhibit mouse brain AChE activity. The in vivo ...

journal_title：Neurochemical research

authors： Arnal F,Coté LJ,Ginsburg S,Lawrence GD,Naini A,Sano M

更新日期：1990-06-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...

journal_title：Neurochemical research

authors： Ijomone OK,Shallie PD,Naicker T

更新日期：2020-04-01 00:00:00

abstract：:SENP3 (SUMO-specific proteases 3), a member of the small ubiquitin-like modifier specific protease family, was identified as a molecule that deconjugates SUMOylation of modified protein substrates and functions as an isopeptidase by disrupting SUMO homeostasis to facilitate cancer development and progression. However,...

journal_title：Neurochemical research

authors： Wei H,Teng H,Huan W,Zhang S,Fu H,Chen F,Wang J,Wu C,Zhao J

更新日期：2012-12-01 00:00:00

abstract：:Proteolipid protein (PLP) is the major intrinsic membrane protein of CNS myelin and is expressed in oligodendrocytes as part of a coordinate program of myelin-specific gene activation. In order to identify the DNA sequences and proteins involved in the regulation of PLP transcription, we have analyzed the 5' flanking ...

journal_title：Neurochemical research

authors： Cambi F,Kamholz J

更新日期：1994-08-01 00:00:00

abstract：:The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...

journal_title：Neurochemical research

authors： Benjamins JA,Nedelkoska L

更新日期：2007-02-01 00:00:00

abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...

journal_title：Neurochemical research

authors： Tasset I,Drucker-Colín R,Peña J,Jimena I,Montilla P,Medina FJ,Túnez I

更新日期：2010-08-01 00:00:00

abstract：:Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...

journal_title：Neurochemical research

authors： Yuwiler A,Bennett BL,Geller E

更新日期：1982-10-01 00:00:00

abstract：:Microvessels were isolated from a bovine cortex and the transport of glucose was investigated by using 2-deoxy-D-[3H]glucose (2-DG). The apparent Km for 2-DG transport was 118 microM and therefore indicates a significant high affinity for the substrate. The inhibition of 2-DG uptake by D-glucose showed an apparent Ki ...

journal_title：Neurochemical research

authors： Stefanovich V,Gojowczyk G

更新日期：1981-04-01 00:00:00

abstract：:The real time dynamics of K+ evoked neurosecretion in cerebellar slices has been monitored electrochemically. In the presence of 5-methyltetrahydrofolate a statistically significant diminution in secretory response occurs. Agonists to probe the pharmacological basis for this indicate it is not due to voltage sensitive...

journal_title：Neurochemical research

authors： Lucock MD,Levene MI,Hartley R

更新日期：1993-05-01 00:00:00

abstract：:Schwann cell biosynthesis of glycolipids was studied by in vitro incorporation of [3H]galactose into neonatal rat sciatic nerves before and after endoneurial explant culture and in culture of purified Schwann cells. In neonatal nerves prior to culture, [3H]galactose was actively incorporated into galactocerebrosides (...

journal_title：Neurochemical research

authors： Yao JK,Windebank AJ,Poduslo JF,Yoshino JE

更新日期：1990-03-01 00:00:00

abstract：:The endogenous opioid peptide dynorphin A elicits non-opioid receptor-mediated neurotoxic effects. These effects are blocked by pretreatment with N-methyl-D-aspartate (NMDA) receptor antagonists. Herein, the mechanism for the non-opioid effects of dynorphin and related peptides was studied by matrix-assisted laser des...

journal_title：Neurochemical research

authors： Woods A,Zangen A

更新日期：2001-04-01 00:00:00