Abstract：
:Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural modifications that may occur later in the life of offspring of PE-like rat model. Pregnant rats divided into early-onset and late-onset groups were administered with N-nitro- L-arginine methyl (L-NAME) through drinking water at gestational days (GD) 8-17. Rats were allowed free access to water throughout the pregnancy. At GD 19, post-natal day (PND) 1 and 60, rats were sacrificed and brain excised for further analysis. The offspring were subjected to behavioural studies for cognitive and sensorimotor impairments before sacrificed at PND 60. Results showed significant down-regulation in the expression of OLIG2 in PE at GD 19 brain which persists till PND 60. Likewise, there was a significant increase in the latency to locate the platform in Morris water maze, time to traverse the balance beam and reduced hanging time on the wire test between the control and the PE treated. PE could lead to impaired neuronal signalling through demyelination which may contributes significantly to long-term sensorimotor and cognitive deficit.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Ijomone OK,Shallie PD,Naicker Tdoi
10.1007/s11064-020-02969-5subject
Has Abstractpub_date
2020-04-01 00:00:00pages
902-914issue
4eissn
0364-3190issn
1573-6903pii
10.1007/s11064-020-02969-5journal_volume
45pub_type
杂志文章abstract：:Cerebral blood flow (CBF) and cerebellar blood flow (CeBF) were measured and correlated with brain lactate, pyruvate and adenosine triphosphate concentrations from groups representing 3-week old suckling (n = 10), 18-22-week old adult (n = 9) and 70-week old aged (n = 7) Sprague-Dawley rats before and during bilateral...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027321203294
更新日期：1997-01-01 00:00:00
abstract：:In human pathology little is known about the activating enzymes for fatty acids of different carbon chain length. In order to have a better insight into disorders of lipid metabolism in human skeletal muscle, we studied the distribution of acyl-CoA synthetases in muscular subcellular fractions. We find that in muscle ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964696
更新日期：1983-05-01 00:00:00
abstract：:Remyelination promoting human IgMs effectively increase the number of myelinated axons in animal models of multiple sclerosis. Hence, they ultimately stimulate myelin production by oligodendrocytes (OLs); however, their exact mechanism of action remains to be elucidated, and in particular, it remains unclear whether t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2701-x
更新日期：2019-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965323
更新日期：1986-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00975043
更新日期：1993-12-01 00:00:00
abstract：:We report further analysis of axonally transported proteoglycans in soluble and membranous subfractions of goldfish optic tectum. Distribution of transported 35SO4 radioactivity was 35.2% soluble, 63.4% Triton-NaCl extractable and 1.4% unextracted. Proteoglycans isolated on DEAE cellulose were treated with chondroitin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00970543
更新日期：1995-02-01 00:00:00
abstract：:Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964414
更新日期：1981-10-01 00:00:00
abstract：:Metformin is the most frequently used drug for the treatment of type 2 diabetes in humans. However, only little is known about effects of metformin on brain metabolism. To investigate potential metabolic consequences of an exposure of brain cells to metformin, we incubated rat astrocyte-rich primary cultures with this...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1733-8
更新日期：2017-01-01 00:00:00
abstract：:Disturbance in cholesterol homeostasis appears to be an important factor in the pathogenesis of neurodegenerative disorders. The aim of the present study was to investigate sterol regulatory element binding protein (SREBP) levels in the nuclear extracts of human neuroblastoma cells and the possible interaction of beta...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9832-4
更新日期：2009-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11064-019-02760-1
更新日期：2019-05-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2040-8
更新日期：2016-11-01 00:00:00
abstract：:Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968406
更新日期：1992-12-01 00:00:00
abstract：:Poly(A)-RNA prepared from the brains of 30-day-old male rats has been shown to direct the synthesis of neuron-specific enolase (NSE) in a cell-free system derived from rabbit reticulocytes. The newly synthesized polypeptides were immunoprecipitated and analyzed on SDS-polyacrylamide slab gels. Autoradiography indicate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964225
更新日期：1980-04-01 00:00:00
abstract：:Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benz...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1723-x
更新日期：2015-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966765
更新日期：1993-09-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-013-1003-6
更新日期：2014-01-01 00:00:00
abstract：:Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9629-5
更新日期：2008-09-01 00:00:00
abstract：:Previous studies suggest that alterations of brain glutamate synthesis and release occur in experimental thiamine deficiency. In order to assess the integrity of post-synaptic glutamatergic receptors in thiamine deficiency, binding sites for [3H]glutamate (displaced by NMDA), [3H]-kainate, and [3H]quisqualate (AMPA si...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00995378
更新日期：1995-10-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-005-6879-3
更新日期：2005-06-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1868-2
更新日期：2016-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965690
更新日期：1991-07-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1020702823600
更新日期：1998-11-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9700-2
更新日期：2008-11-01 00:00:00
abstract：:Methamphetamine (MA), an amphetamine-type psychostimulant, is associated with dopaminergic toxicity and has a high abuse potential. Numerous in vivo and in vitro studies have suggested that impaired mitochondria are critical in dopaminergic toxicity induced by MA. Mitochondria are important energy-producing organelles...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2318-5
更新日期：2018-01-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-010-0323-z
更新日期：2010-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-008-9847-x
更新日期：2009-05-01 00:00:00
abstract：:Using the immunoblot technique, we found that an incubation of purified human myelin in 10 mM Tris-HCl buffer at pH 7.5 resulted in the conversion of the myelin-associated glycoprotein (MAG) to a smaller derivative (dMAG). Exogenously added 5 mM CaCl2 accelerated the conversion of MAG. In buffer containing more than 1...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964509
更新日期：1984-05-01 00:00:00
abstract：:Neurons of the rat cerebral hemispheres are known to undergo a postnatal shift to a short DNA repeat length. In the present study we report that rat neuronal nuclei are more sensitive to digestion with DNAse I when isolated at a developmental stage after the shift in neuronal DNA repeated length compared to nuclei iso...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965136
更新日期：1982-08-01 00:00:00
abstract：:The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966726
更新日期：1994-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is a common neurodegenerative condition that affects the elderly population. Its primary symptom is memory loss. The memory dysfunction in AD has been associated with cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). Zizyphus jujube (ZJ) a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1232-8
更新日期：2014-02-01 00:00:00
