Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis-A Review.

abstract：:The synthetic Liver X receptor (LXR) activator T0901317 has been reported to exert neuroprotective effect in Alzheimer's disease, but the relationship between LXR activation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) remains uncertain. This study investigated the effect of T0901317 on membrane ...

journal_title：Neurochemical research

authors： Cui W,Sun Y,Wang Z,Xu C,Xu L,Wang F,Chen Z,Peng Y,Li R

更新日期：2011-10-01 00:00:00

abstract：:Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of nicotine may prove to be a valuable pharmaceutical agent for the treatment of AD. However, the beneficial effects of nicotine remain a matter of much controversy. In o...

journal_title：Neurochemical research

authors： Shim SB,Lee SH,Chae KR,Kim CK,Hwang DY,Kim BG,Jee SW,Lee SH,Sin JS,Bae CJ,Lee BC,Lee HH,Kim YK

更新日期：2008-09-01 00:00:00

abstract：:Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumu...

journal_title：Neurochemical research

authors： Ferrari DC,Nesic O,Perez-Polo JR

更新日期：2010-12-01 00:00:00

abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...

journal_title：Neurochemical research

authors： Zirrgiebel U,Lindholm D

更新日期：1996-07-01 00:00:00

abstract：:Pathogens such as bacterial lipopolysaccharide (LPS) play an important role in promoting the production of the inflammatory cytokines interleukin-1 beta (IL-1β) and tumour necrosis factor-α (TNF-α) in response to infection or damage in microglia. However, whether different signalling pathways regulate these two inflam...

journal_title：Neurochemical research

authors： Fu SY,Xiong RP,Peng Y,Zhang ZH,Chen X,Zhao Y,Ning YL,Yang N,Zhou YG,Li P

更新日期：2019-12-01 00:00:00

abstract：:Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...

journal_title：Neurochemical research

authors： Thatcher NM,Badar-Goffer RS,Ben-Yoseph O,McLean MA,Morris PG,Prior MJ,Taylor A,Bachelard HS

更新日期：2002-02-01 00:00:00

abstract：:Pig brain cerebral cortex was subfractionated by isopycnic centrifugation in sucrose gradients. In each subfraction the content of the agonist [3H]R-PIA binding, the activity of adenosine metabolizing enzymes (5'-nucleotidase and adenosine deaminase) and the activity of membrane marker enzymes were determined. The fra...

journal_title：Neurochemical research

authors： Casadó V,Lluis C,Canela E,Franco R,Mallol J

更新日期：1992-02-01 00:00:00

abstract：:Although nitric oxide (NO) plays key signaling roles in the nervous systems, excess NO leads to cell death. In this study, the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and apoptosis signal-regulating kinase-1 (ASK1) in NO-induced cell death was investigated in PC12 cells. NO donor transiently act...

journal_title：Neurochemical research

authors： Han OJ,Joe KH,Kim SW,Lee HS,Kwon NS,Baek KJ,Yun HY

更新日期：2001-05-01 00:00:00

abstract：:The carnitine/acylcarnitine transporter is a transport system whose function is essential for the mitochondrial β-oxidation of fatty acids. Here, the presence of carnitine/acylcarnitine carrier (CACT) in nervous tissue and its sub-cellular localization in dorsal root ganglia (DRG) neurons have been investigated. Weste...

journal_title：Neurochemical research

authors： Tonazzi A,Mantovani C,Colella M,Terenghi G,Indiveri C

更新日期：2013-12-01 00:00:00

abstract：:Rabbits were immunized with the myelin-associated glycoprotein (MAG) that had been purified from isolated rat brain myelin by selective extraction with lithium diiodosalicylate (LIS) and phenol followed by preparative SDS gel electrophoresis. Antibodies to MAG were detected qualitatively by immunodiffusion and quantit...

journal_title：Neurochemical research

authors： Quarles RH,Johnson D,Brady RO,Sternberger NH

更新日期：1981-10-01 00:00:00

abstract：:T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...

journal_title：Neurochemical research

authors： Iwasaki Y,Ikeda K,Ichikawa Y,Igarashi O,Kinoshita M,Marubuchi S,Ono S

更新日期：2002-03-01 00:00:00

abstract：:The composition of retrogradely transported axonal proteins was examined by acrylamide gel electrophoresis and gel autoradiography in the experimental neuropathy induced in rats by p-bromophenylacetylurea (BPAU). Protein composition was normal during the early phase of retrograde transport but showed significant abnor...

journal_title：Neurochemical research

authors： Oka N,Brimijoin S

更新日期：1993-06-01 00:00:00

abstract：:Tamoxifen and toremifene are antiestrogenic drugs successfully used in the therapy of breast cancer. Rheumatoid arthritis and malaria have been treated with chloroquine for decades. Unfortunately, tamoxifen and chloroquine are reported to induce retinal changes as a side effect. We now studied the effects of tamoxifen...

journal_title：Neurochemical research

authors： Mäenpää H,Toimela T,Mannerström M,Saransaari P,Tähti H

更新日期：2004-01-01 00:00:00

abstract：:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activ...

journal_title：Neurochemical research

authors： Chechik T,Poduslo SE

更新日期：1987-01-01 00:00:00

abstract：:Intracerebral folate injections produce convulsions and brain lesions, folic acid itself and tetrahydrofolate being more potent toxins than 5-methyltetrahydrofolate, the primary folate of mammalian extracellular fluids. Folates are known to excite neurons, by unknown mechanisms Folates stimulate GTP binding and GTPase...

journal_title：Neurochemical research

authors： Hartley DM,Snodgrass SR

更新日期：1990-07-01 00:00:00

abstract：:There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well. In this study, we investigated the mechanism of ceramide-i...

journal_title：Neurochemical research

authors： Strazza M,Luddi A,Brogi A,Carbone M,Riccio M,Santi S,Melli M,Costantino-Ceccarini E

更新日期：2004-05-01 00:00:00

abstract：:A simple, rapid method for determining depolarization-induced 45Ca influx into synaptosomes is described. Synaptosomes which had been depolarized in the presence of 45Ca were applied to a small column of Chelex-100 resin to separate free Ca2+ from that taken up by the tissue. Approximately 70% of the synaptosomal prot...

journal_title：Neurochemical research

authors： Michaelis ML,Michaelis EK,Simpson AE

更新日期：1982-02-01 00:00:00

abstract：:Specific [3H]MK801 binding to rat brain NMDA receptors after the administration of the convulsant drug 3-mercaptopropionic acid (MP) and the adenosine analogue cyclopentyladenosine (CPA) was studied by means of a quantitative autoradiographic method. MP administration (150 mg/kg, i.p.) caused significant decreases in ...

journal_title：Neurochemical research

authors： Giraldez L,Girardi E

更新日期：1998-10-01 00:00:00

abstract：:Mouse isolated vas deferens preincubated with [3-H]noradrenaline was superfused and the effect of alpha 1-adrenoceptor agonists was studied on the release of total radioactivity ([3H]noradrenaline + 3H-metabolites) and [3H]noradrenaline. Reverse phase high pressure liquid chromatography (HPLC) combined with scintillat...

journal_title：Neurochemical research

authors： Vizi ES,Somogyi GT,Harsing LG Jr,Zimanyi I

更新日期：1986-01-01 00:00:00

abstract：:We previously showed that extracellular levels of N-acetylaspartate (NAA) increase when a medium with reduced NaCl concentration is perfused through a microdialysis probe, and proposed that NAA may be released during hypoosmotic swelling. Here, we demonstrate that this effect is due to hypoosmolarity of the perfusion ...

journal_title：Neurochemical research

authors： Davies SE,Gotoh M,Richards DA,Obrenovitch TP

更新日期：1998-08-01 00:00:00

abstract：:A double ligand enzyme-linked immunosorbent assay (ELISA) has been developed to detect antibodies against brain tissue antigens in the sera of patients with neurological diseases. The sera were tested on human white matter homogenate. The technique consists of successive incubations with the human serum to be tested, ...

journal_title：Neurochemical research

authors： Bologa L,Hofstetter W,Schonenberger K,Jacque C,Herschkowitz N

更新日期：1985-04-01 00:00:00

abstract：:Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...

journal_title：Neurochemical research

authors： Fei Y,Wang X,Chen S,Zhou Q,Zhang C,Li Y,Sun L,Zhang L

更新日期：2016-07-01 00:00:00

abstract：:Exposure to Hg2+ below 10 micrometer destroys synaptosomal membrane-associated sialidase of bovine brain in situ. Inhibition by Cu2+ occurs only at relatively higher concentrations, and is demonstrable after the synaptosomal membrane preparation has been presaturated with Cu2+ . Pb2+ does not inhibit enzymatic activit...

journal_title：Neurochemical research

authors： Yohe HC,Rosenberg A

更新日期：1978-02-01 00:00:00

abstract：:Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...

journal_title：Neurochemical research

authors： Mutsuga N,Gainer H

更新日期：2006-02-01 00:00:00

abstract：:TRH-like immunoreactivity distinct from TRH is present in various tissues and fluids. In order to determine whether TRH-like molecules are secreted by the hypothalamus, we analyzed tissues and media from hypothalamic slices incubated in Krebs Ringer bicarbonate. Media from basal or high KCl conditions contained 3 TRH-...

journal_title：Neurochemical research

authors： Méndez M,Cisneros M,Baez A,Joseph-Bravo P,Charli JL

更新日期：1999-07-01 00:00:00

abstract：:Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysi...

journal_title：Neurochemical research

authors： Borowicz-Reutt KK,Banach M,Piskorska B

更新日期：2016-05-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...

journal_title：Neurochemical research

authors： Ijomone OK,Shallie PD,Naicker T

更新日期：2020-04-01 00:00:00

abstract：:Metal ions are often used to block calcium channels in various tissues, including synaptosomes. In the present study, Fura-2 was used to determine the effectiveness of various metal ions as calcium channel blockers in rat brain synaptosomes in vitro. In buffer solutions, La3+ and Cd2+ increased the Fura-2 fluorescence...

journal_title：Neurochemical research

authors： Sun YD,Benishin CG

更新日期：1989-11-01 00:00:00

abstract：:The aggravated risk on intracerebral hemorrhage (ICH) with drugs used for stroke patients should be estimated carefully. We therefore established sensitive quantification methods and provided a rat ICH model for detection of ICH deterioration. In ICH intrastriatally induced by 0.014-unit, 0.070-unit, and 0.350-unit co...

journal_title：Neurochemical research

authors： Terai K,Suzuki M,Sasamata M,Miyata K

更新日期：2003-05-01 00:00:00

abstract：:Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...

journal_title：Neurochemical research

authors： Chen Z,Hu Q,Xie Q,Wu S,Pang Q,Liu M,Zhao Y,Tu F,Liu C,Chen X

更新日期：2019-04-01 00:00:00