Abstract:
:Neurons, purified by bulk-isolation procedures from 10 day-old rat brain, are 80-90% homogeneous. Contaminants are primarily blood vessels and occasional oligodendroglia. All sizes and shapes of neurons are obtained, as they are isolated from all areas of the brain, except the cerebellum. Neurotransmitter enzyme activities involved in the metabolism of catecholamines, acetylcholine, and GABA are found at twice the level in these purified neurons when compared to that found in whole brain tissue. However, acetycholinesterase is found at a similar activity as in whole brain tissue, suggesting its localization in other cell types as well. Thus purified rat neurons are a good model system for studying neuronal function.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Chechik T,Poduslo SEdoi
10.1007/BF00971368subject
Has Abstractpub_date
1987-01-01 00:00:00pages
79-82issue
1eissn
0364-3190issn
1573-6903journal_volume
12pub_type
杂志文章abstract::Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...
journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00965193
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1979-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971007
更新日期:1987-07-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1986-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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更新日期:2007-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965136
更新日期:1982-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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更新日期:2016-06-01 00:00:00
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更新日期:2012-12-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965545
更新日期:1991-06-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:2015-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1978-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1993-02-01 00:00:00
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更新日期:2015-08-01 00:00:00
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更新日期:2014-02-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1992-06-01 00:00:00
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journal_title:Neurochemical research
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更新日期:2012-02-01 00:00:00