Abstract:
:Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of cyclinD1 in controlling the self-renewal and differentiation of NSCs. Moreover, we found that the over-expression of cyclinD1 can drive cells to enter S phase and support the clonal self-renewing growth of NSCs. During the differentiation of NSCs, the over-expression of cyclinD1 promoted the generation of astrocytes, and their promotion likely occurred through synergistic phosphorylation of the signal transducer and activator of transcription 3. Our data suggest that the over-expression of cyclinD1 promotes the proliferation of NSCs and induces their differentiation into astrocytes via Jak-STAT3 pathways.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Ma J,Cui B,Ding X,Wei J,Cui Ldoi
10.1007/s11064-015-1635-9subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1681-90issue
8eissn
0364-3190issn
1573-6903journal_volume
40pub_type
杂志文章abstract::Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by α-synuclein toxicity, which is also associated with the higher le...
journal_title:Neurochemical research
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abstract::Unrelated cells such as dental follicle precursor cells (DFPCs) and retinal Müller cells (MCs) make spheres after cultivation in serum-replacement medium (SRM). Until today, the relation and molecular processes of sphere formation from different cell types remain undescribed. Thus in this study we compared proteomes o...
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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doi:10.1007/s11064-010-0316-y
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journal_title:Neurochemical research
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