Abstract:
:Parkinson's disease (PD) is characterized by the presence of insoluble protein clusters containing α-synuclein. Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by α-synuclein toxicity, which is also associated with the higher levels of ROS found in the aged brain and in PD. Oxidative stress leads to protein oligomerization and aggregation that impair autophagy and mitochondrial dynamics leading to a vicious cycle of organelles damage and neurodegeneration. In this review we focused on the role of α-synuclein dysfunction as a cellular stressor that impairs mitochondria, endoplasmic reticulum, autophagy and cellular dynamics culminating with dopaminergic depletion and the pathogenesis of PD.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Melo TQ,Copray SJCVM,Ferrari MFRdoi
10.1007/s11064-018-2673-xsubject
Has Abstractpub_date
2018-12-01 00:00:00pages
2212-2223issue
12eissn
0364-3190issn
1573-6903pii
10.1007/s11064-018-2673-xjournal_volume
43pub_type
杂志文章,评审abstract::The effect of light exposure on the protein patterns of optic lobe and forebrain of the chick embryo was analysed by a high-resolution micro-two-dimensional polyacrylamide gel electrophoresis and computerized quantitation. Experiments were done on three groups of eggs: control group was incubated in the dark; simultan...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00993240
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abstract::In our previous study vesamicol, an inhibitor of the acetylcholine transporter of the cholinergic vesicles, inhibited veratridine-evoked external Ca(2+)-dependent acetylcholine release from striatal slices but did not influence acetylcholine release observed in Ca(2+)-free medium (4). Here we examined if the effect of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968780
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abstract::This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...
journal_title:Neurochemical research
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doi:10.1007/BF00969761
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abstract::The mutual interactions and the effects of GABA on the saturable transport components of taurine and hypotaurine were investigated with mouse brain slices. The low-affinity taurine transport was competitively inhibited by both hypotaurine and GABA. Hypotaurine did not alter the kinetic parameters of high-affinity taur...
journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1983-11-01 00:00:00
abstract::In the unrestrained rat, the hyperphagic-like ingestion of food evoked by the sustained elevation of neuropeptide-Y (NPY) in the hypothalamus was correlated with the release and turnover of monoaminergic transmitters in this structure. A single guide tube was implanted stereotaxically in the perifornical region of the...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967290
更新日期:1992-11-01 00:00:00
abstract::Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...
journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964513
更新日期:1984-05-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973296
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journal_title:Neurochemical research
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract::The cellular effects of eleven compounds including chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives were studied in rat pheochromocytoma PC12 cells. Of the compounds tested, 4'-O-β-D-glucopyranosyl-3',4-dimethoxychalcone (A2) significantly increased the levels of the phosph...
journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01101714
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journal_title:Neurochemical research
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pub_type: 杂志文章
doi:10.1007/s11064-010-0203-6
更新日期:2010-09-01 00:00:00
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journal_title:Neurochemical research
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journal_title:Neurochemical research
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