Mutual interactions in the transport of taurine, hypotaurine, and GABA in brain slices.

abstract：:The effects of 100microg melatonin injection at postnatal day 5 (PD 5) on the development of the central serotonergic systems in male and female rats were investigated. The contents of serotonin (5-HT) and 5-hydroxy-3-indolacetic acid (5-HIAA) were measured in several extrahypothalamic regions at 3, 10 and 42 weeks of...

journal_title：Neurochemical research

authors： Muneoka K,Ogawa T,Takigawa M

更新日期：2000-06-01 00:00:00

abstract：:Detergents Triton X-100, sodium deoxycholate, and octyl-beta-D-glucopyranoside, and proteinase papain proved to be excellent agents solubilizing the gamma-glutamyltransferase (gamma-GT) from human brain cortex microvessels. Ficin also solubilized gamma-GT but to a lesser extent than papain. The relative molecular mass...

journal_title：Neurochemical research

authors： Veselý J,Cernoch M

更新日期：1984-07-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder of dopaminergic, noradrenergic, and serotonergic systems, in which dopamine, noradrenaline, and serotonin levels are depleted and lead to the development of motor and non-motor symptoms such as tremor, bradykinesia, weight changes, fatigue, depression, and visua...

journal_title：Neurochemical research

authors： Parambi DGT,Saleem U,Shah MA,Anwar F,Ahmad B,Manzar A,Itzaz A,Harilal S,Uddin MS,Kim H,Mathew B

更新日期：2020-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downre...

journal_title：Neurochemical research

authors： Wang W,Duan W,Wang Y,Wen D,Liu Y,Li Z,Hu H,Cui H,Cui C,Lin H,Li C

更新日期：2017-04-01 00:00:00

abstract：:The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the phar...

journal_title：Neurochemical research

authors： Roques BP,Noble F

更新日期：1996-11-01 00:00:00

abstract：:Hypothalamic and plasma dopamine-beta-hydroxylase [DBH, EC 1.14.2.1] activites were measured by a coupled radioenzymatic method. Animals representing five experimental groups [intact controls, adrenalectomized, pinealectomized, adrenalectomized pinealectomized, doubly sham-operated] were killed and sampled at 8 times ...

journal_title：Neurochemical research

authors： Banerji TK,Quay WB,Kachi T

更新日期：1978-06-01 00:00:00

abstract：:The role of protein phosphorylation in catecholamine secretion from bovine adrenomedullary chromaffin cells was studied using different protein kinase inhibitors. Naphthalenesulfonamide derivatives as ML9 and ML7, more specific for the myosin light chain kinase, and the calmodulin antagonist W7 inhibited catecholamine...

journal_title：Neurochemical research

authors： Reig JA,Viniegra S,Ballesta JJ,Palmero M,Guitierrez LM

更新日期：1993-03-01 00:00:00

abstract：:During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells, triggering multiple cellular responses to injury. Here, we evaluated changes in extracellular ATP, ADP and AMP hydrolysis at different times (0-24 hours) after unilateral cortical stab injury (CSI) in adul...

journal_title：Neurochemical research

authors： Nedeljkovic N,Bjelobaba I,Lavrnja I,Stojkov D,Pekovic S,Rakic L,Stojiljkovic M

更新日期：2008-05-01 00:00:00

abstract：:The oxidation of pyruvate is mediated by the pyruvate dehydrogenase complex (PDHC; EC 1.2.4.1, EC 2.3.1.12 and EC 1.6.4.3) whose catalytic activity is influenced by phosphorylation and by product inhibition. 2-Oxoglutarate and 3-hydroxybutyrate are readily utilized by brain mitochondria and inhibit pyruvate oxidation....

journal_title：Neurochemical research

authors： Lai JC,Sheu KF

更新日期：1987-08-01 00:00:00

abstract：:We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-family member thioredoxin (THX), and asked whether changes in PDI/THX were associated with production of oxidative/nitro...

journal_title：Neurochemical research

authors： Tshala-Katumbay D,Desjardins P,Sabri M,Butterworth R,Spencer P

更新日期：2009-11-01 00:00:00

abstract：:Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of importan...

journal_title：Neurochemical research

authors： Wang Y,Sun D,Yue Z,Tang W,Xiao B,Feng L

更新日期：2016-09-01 00:00:00

abstract：:Transferrin (Tf), the iron-transport protein of vertebrate serum, is mainly synthesized in hepatocytes but is also found in other cell-types including oligodendrocytes. Our laboratory has characterized in a human oligodendrial cell line the presence of a new Tf transcript containing an alternative exon 1b replacing th...

journal_title：Neurochemical research

authors： Duchange N,Saleh MC,de Arriba Zerpa G,Pidoux J,Guillou F,Zakin MM,Baron B

更新日期：2002-11-01 00:00:00

abstract：:The metabolic effects of ganglioside GM1 were found to be quite different in brain synaptosomes and phagocytic cells. Incubation of rat brain cortex synaptosomes with GM1 was shown to decrease the production of reactive oxygen species induced by Fe2+-H2O2 system and measured by chemiluminometric method in the presence...

journal_title：Neurochemical research

authors： Avrova NF,Zakharova IO,Tyurin VA,Tyurina YY,Gamaley IA,Schepetkin IA

更新日期：2002-08-01 00:00:00

abstract：:Chemokines are small secreted proteins that are essential for the recruitment and activation of specific leukocyte subsets at sites of inflammation and for the development and homeostasis of lymphoid and nonlymphoid tissues. During the past decade, chemokines and their receptors have also emerged as key signaling mole...

journal_title：Neurochemical research

authors： Ambrosini E,Aloisi F

更新日期：2004-05-01 00:00:00

abstract：:The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...

journal_title：Neurochemical research

authors： Xie J,Han F,Shi Y

更新日期：2014-04-01 00:00:00

abstract：:Previous work from this laboratory and others has shown that neurotransmitters can activate phospholipase D. Unlike the phospholipase C that specifically hydrolyzes inositol-containing phospholipids, phospholipase D in neuronal tissue specifically hydrolyzes phosphatidylcholine. One route for the synthesis of phosphat...

journal_title：Neurochemical research

authors： Jacobs TQ,Passarello B,Horwitz J

更新日期：1998-08-01 00:00:00

abstract：:Methylphenidate is commonly used for the treatment of attention deficit/hyperactivity disorder. There are still few works regarding the effects of methylphenidate on brain energy metabolism. Thus, in the present study we evaluated the effect of chronic administration of methylphenidate on the activities of mitochondri...

journal_title：Neurochemical research

authors： Fagundes AO,Aguiar MR,Aguiar CS,Scaini G,Sachet MU,Bernhardt NM,Rezin GT,Valvassori SS,Quevedo J,Streck EL

更新日期：2010-11-01 00:00:00

abstract：:Nicotine has been reported to exert certain protective effect in the Parkinson's and Alzheimer's diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (-)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before t...

journal_title：Neurochemical research

authors： Chen Y,Nie H,Tian L,Tong L,Yang L,Lao N,Dong H,Sang H,Xiong L

更新日期：2013-02-01 00:00:00

abstract：:Mitochondrial division inhibitor 1 (Mdivi-1) is the most effective pharmacological inhibitor of mitochondrial fission. Spinal cord injury (SCI) is a common and serious trauma, which lacks efficient treatment. This study aimed to detect the role of Mdivi-1 in neuronal injury and its underlying mechanism after acute SCI...

journal_title：Neurochemical research

authors： Li G,Jia Z,Cao Y,Wang Y,Li H,Zhang Z,Bi J,Lv G,Fan Z

更新日期：2015-07-01 00:00:00

abstract：:We review some of the older literature concerning metabolic turnover of cholesterol in the nervous system. The overall picture is that incorporation of radioactive precursors into brain cholesterol is roughly proportional to the rate of myelination and that, once incorporated, radioactive cholesterol is relatively sta...

journal_title：Neurochemical research

authors： Morell P,Jurevics H

更新日期：1996-04-01 00:00:00

abstract：:The primary objective of this investigation was to assess the neuroprotective efficacy of spice active principles namely Eugenol (Eug) and isoeugenol (IE) in an acrylamide (ACR) neuropathy model in rats. In the present study, ACR administration (50 mg/kg bw, i.p. 3 times/week) for 5 weeks to growing rats caused typica...

journal_title：Neurochemical research

authors： Prasad SN,Muralidhara

更新日期：2013-02-01 00:00:00

abstract：:The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomers and seed aggregates to initiate the events of nucleation and elongation,...

journal_title：Neurochemical research

authors： Padayachee ER,Arowolo A,Whiteley CG

更新日期：2014-01-01 00:00:00

abstract：:Caspase activation and apoptotic events may take place in terminal regions far removed from the cell body and contribute to synapse loss in neurodegenerative diseases. For examination of events in terminals, we have developed a cell-free assay using quantitative flow cytometric analysis (fluorescence-activated cell so...

journal_title：Neurochemical research

authors： Gylys KH,Fein JA,Cole GM

更新日期：2002-06-01 00:00:00

abstract：:Level of adenosine, an endogenous astrocyte-based neuromodulator, is primarily regulated by adenosine P1 receptors. This study assessed expression of adenosine P1 receptors, ADORA1 (adenosine A1 receptor) and ADORA2A (adenosine A2a receptor) and their association with glioma development and epilepsy in glioma patients...

journal_title：Neurochemical research

authors： Huang J,Chen MN,Du J,Liu H,He YJ,Li GL,Li SY,Liu WP,Long XY

更新日期：2016-07-01 00:00:00

abstract：:A previous study conducted in this laboratory revealed a decrease in total cholinesterase (total ChE) in the cerebral cortex, hippocampus and striatum in aged rats (24 months) of various strains, as compared with young animals (3 months). The purpose of the present experiments was to extend the study to other brain ar...

journal_title：Neurochemical research

authors： Meneguz A,Bisso GM,Michalek H

更新日期：1992-08-01 00:00:00

abstract：:Postnatal developmental patterns of activity for acid and alkaline deoxyribonuclease (DNase) were determined in the cerebellum of the androgenized female rat. Littermates were injected s.c. with either 1.25 mg testosterone propionate (TP) or vehicle 48 hours after birth. The enzymes and DNA content were measured in th...

journal_title：Neurochemical research

authors： Litteria M

更新日期：1985-04-01 00:00:00

abstract：:The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....

journal_title：Neurochemical research

authors： Mishra OP,Delivoria-Papadopoulos M

更新日期：1992-12-01 00:00:00

abstract：:The Editors have retracted this article [1] following an investigation conducted by the journal. After publication concerns were raised regarding interpretation of the data presented in Fig. 4. The Editors requested additional data and clarification to confirm interpretation of data results. After further review, the ...

journal_title：Neurochemical research

authors： Zhang J,Liu Z,Pei Y,Yang W,Xie C,Long S

更新日期：2020-09-01 00:00:00

abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...

journal_title：Neurochemical research

authors： Xu J,Song D,Xue Z,Gu L,Hertz L,Peng L

更新日期：2013-03-01 00:00:00

abstract：:Apoptotic cell death pathways have been implicated in acute brain injuries, including cerebral ischemia, brain trauma, and spinal cord injury, and in chronic neurodegenerative diseases. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and su...

journal_title：Neurochemical research

authors： Chan PH

更新日期：2004-11-01 00:00:00