Effects of neonatal melatonin administration on the extra-hypothalamic regions in rat brains: effects on the serotonergic system.

abstract：:When excised goldfish spinal cord is kept in physiological saline at room temperature, the myelin multilayers swell. As studied by X-ray diffraction, the original repeating distance of 150 A (AS myelin) swells to 177 A (AL myelin); no intermediate distances are seen. At least 70% of the myelin can undergo this gradual...

journal_title：Neurochemical research

authors： Blaurock AE,Yale JL,Roots BI

更新日期：1986-08-01 00:00:00

abstract：:To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI...

journal_title：Neurochemical research

authors： Xie W,Yang SY,Zhang Q,Zhou Y,Wang Y,Liu R,Wang W,Shi J,Ning B,Jia T

更新日期：2018-08-01 00:00:00

abstract：:The aim of this study was to determine the anticancer potential of Leonurus sibiricus extract derived from in vitro transgenic roots transformed by Agrobacetrium rhizogenes with AtPAP1 transcriptional factor, and that of transformed roots without construct, on grade IV human glioma cells and the U87MG cell line, and a...

journal_title：Neurochemical research

authors： Sitarek P,Kowalczyk T,Santangelo S,Białas AJ,Toma M,Wieczfinska J,Śliwiński T,Skała E

更新日期：2018-07-01 00:00:00

abstract：:Glycogen is the main storage form of glucose in the brain. In contrast with previous beliefs, brain glycogen has recently been shown to play important roles in several brain functions. A fraction of metabolized glucose molecules are being shunted through glycogen before reentering the glycolytic pathway, a phenomenon ...

journal_title：Neurochemical research

authors： Jakobsen E,Bak LK,Walls AB,Reuschlein AK,Schousboe A,Waagepetersen HS

更新日期：2017-09-01 00:00:00

abstract：:DYT1 dystonia is caused by a glutamic acid deletion (ΔE) in the endoplasmic reticulum (ER) protein torsinA. Previous studies suggest that torsinA modulates the aggregation of cytosolic misfolded proteins and ER stress responses, although the mechanisms underlying those effects remain unclear. In order to investigate t...

journal_title：Neurochemical research

authors： Gordon KL,Glenn KA,Gonzalez-Alegre P

更新日期：2011-03-01 00:00:00

abstract：:One of the many pharmacological targets of ethanol is the GABA inhibitory system, and chronic ethanol (CE) is known to alter the polypeptide levels of the GABA(A )receptor subunits in rat brain regions. In the present study, we investigated the regulation of the tyrosine kinase phosphorylation of the GABA(A) receptor ...

journal_title：Neurochemical research

authors： Marutha Ravindran CR,Mehta AK,Ticku MK

更新日期：2007-07-01 00:00:00

abstract：:Schwann cell biosynthesis of glycolipids was studied by in vitro incorporation of [3H]galactose into neonatal rat sciatic nerves before and after endoneurial explant culture and in culture of purified Schwann cells. In neonatal nerves prior to culture, [3H]galactose was actively incorporated into galactocerebrosides (...

journal_title：Neurochemical research

authors： Yao JK,Windebank AJ,Poduslo JF,Yoshino JE

更新日期：1990-03-01 00:00:00

abstract：:The hypothalamic paraventricular nucleus (PVN) is a key site for regulating neuroendocrine functions in the magnocellular part and autonomic activities in the parvocellular part. Its anatomical proximity to the third ventricle could be a good target for intrathecal injection of baclofen. We investigated the correlatio...

journal_title：Neurochemical research

authors： Czell D,Efe T,Preuss M,Schofer MD,Becker R

更新日期：2012-02-01 00:00:00

abstract：:We observed a spot on two-dimensional (2-D) gel in the epileptic mutant strain E1 mice with a similar molecular weight but with a different isoelectric point of approximately 0.2, compared with its mother strain ddY mice. The collected protein from the E1 mice was identified as cytosolic NADP+-dependent isocitrate deh...

journal_title：Neurochemical research

authors： Ohmori O,Hirano H,Mita T

更新日期：1999-03-01 00:00:00

abstract：:Studies on primary astrocytes cultured in vitro have shown that process formation involves changes in cytoskeletal proteins and release of tension on the substratum. Actin filament reorganization has previously been found to be the major cytoskeletal change occurring during process formation. These changes are relativ...

journal_title：Neurochemical research

authors： Padmanabhan J,Shelanski ML

更新日期：1998-03-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease, with genetics and environment contributing to the disease onset. The limited pathological cognize of the disease restrained the approaches to improve the clinical treatment. Recently, studies showed that endoplasmic reticulum (ER) stress played an important role...

journal_title：Neurochemical research

authors： Ning B,Deng M,Zhang Q,Wang N,Fang Y

更新日期：2016-08-01 00:00:00

abstract：:Chlorpyrifos (CPF), an organophosphorus insecticide is known to cause ill health in non-target animals by inducing oxidative stress. In this study influence of cold stress (15°C and 20°C) and age as modulating factors on CPF induced oxidative stress was addressed to assess age-related differences and vulnerability in ...

journal_title：Neurochemical research

authors： Basha PM,Poojary A

更新日期：2011-02-01 00:00:00

abstract：:Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervo...

journal_title：Neurochemical research

authors： Nieoczym D,Socała K,Wlaź P

更新日期：2018-05-01 00:00:00

abstract：:Systemic inflammation is present in obesity and emerging evidence, primarily from studies using male rodents fed high-fat diets, suggests neuroimmune signaling also is involved. We investigated early changes in neuroimmune signaling during the weight gain that follows ovariectomy in rats. Ovariectomized (OVX) rats wer...

journal_title：Neurochemical research

authors： Curtis KS,McCracken K,Espinosa E,Ong J,Buck DJ,Davis RL

更新日期：2018-09-01 00:00:00

abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...

journal_title：Neurochemical research

authors： Ono K

更新日期：2017-12-01 00:00:00

abstract：:N-Acetylaspartic and N-acetylaspartylglutamic acid concentrations in human ventricular, subarachnoid and lumbar cerebrospinal fluid were measured by combined gas chromatography-mass spectrometry using selected ion monitoring with deuterated internal standards. N-Acetylaspartate concentrations were in the range 55, 9, ...

journal_title：Neurochemical research

authors： Faull KF,Rafie R,Pascoe N,Marsh L,Pfefferbaum A

更新日期：1999-10-01 00:00:00

abstract：:In the present work we investigated the in vitro effect of the branched-chain amino acids (BCAA) accumulating in maple syrup urine disease (MSUD) on some parameters of energy metabolism in cerebral cortex of rats. 14CO2 production from [1-14C]acetate, [1-5-14C]citrate and [U-14C]glucose, as well as glucose uptake by t...

journal_title：Neurochemical research

authors： Ribeiro CA,Sgaravatti AM,Rosa RB,Schuck PF,Grando V,Schmidt AL,Ferreira GC,Perry ML,Dutra-Filho CS,Wajner M

更新日期：2008-01-01 00:00:00

abstract：:Probenecid inhibits the transport of the small monocarboxylic acids lactate and propionate from blood to brain but does not affect the transport of 5HIAA or HVA. Neither lactate, 5HIAA, HVA, nor probenecid itself inhibits probenecid uptake into brain from blood and neither lactate nor 5HIAA itself inhibits 5HIAA uptak...

journal_title：Neurochemical research

authors： Yuwiler A,Bennett BL,Geller E

更新日期：1982-10-01 00:00:00

abstract：:The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. In the first two experiments corticosterone significantl...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Taljaard JJ

更新日期：1992-03-01 00:00:00

abstract：:Astrocytes transport the monocarboxylate acetate, but synaptosomes do not. The reason for this is unknown, because both preparations express monocarboxylate transporters (MCT). The transport and metabolism of lactate, another monocarboxylate, was examined in these two preparations, and the results were compared to tho...

journal_title：Neurochemical research

authors： Waniewski RA,Martin DL

更新日期：2004-01-01 00:00:00

abstract：:One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melaton...

journal_title：Neurochemical research

authors： Li X,Zhang M,Tang W

更新日期：2013-03-01 00:00:00

abstract：:Endogenous and xenobiotic sulphur-containing convulsant and non-convulsant compounds containing structural moieties of, or bearing a structural resemblance to, GABA and homocysteine were tested in binding studies for their potency in displacing the GABA-mimetic [3H]muscimol from specific, high-affinity sites (Kd = 3.6...

journal_title：Neurochemical research

authors： Egbuta JO,Griffiths R

更新日期：1987-07-01 00:00:00

abstract：:Hyperhomocysteinemia occurs in homocystinuria, an inherited metabolic disease clinically characterized by thromboembolic episodes and a variable degree of neurological dysfunction whose pathophysiology is poorly known. In this study, we induced elevated levels of homocysteine (Hcy) in blood (500 microM), comparable to...

journal_title：Neurochemical research

authors： Streck EL,Matte C,Vieira PS,Rombaldi F,Wannmacher CM,Wajner M,Wyse AT

更新日期：2002-12-01 00:00:00

abstract：:Metabolic turnover of axonally transported glycoproteins has been examined in membranous and soluble subfractions of goldfish optic tectum following intraocular injection of [3H]fucose. Radioactivity in total transported glycoproteins reached a maximum in the tectum after 24-30 hr, then declined with a half-life of ap...

journal_title：Neurochemical research

authors： Ripellino JA,Elam JS

更新日期：1980-04-01 00:00:00

abstract：:We observed that AP-3, an antagonist of metabotropic glutamate receptors, reduced carbachol-induced hydrolysis of phospholipids in hippocampal slices. This inhibition could be explained in different ways, e.g.: 1) AP-3 acts also as antagonist of muscarinic receptors mediating the hydrolysis of phospholipids induced by...

journal_title：Neurochemical research

authors： Llansola M,Hermenegildo C,Miñana MD,Felipo V

更新日期：1998-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the aged population. Early-onset familial AD (FAD) involves mutations in a gene on chromosome 21 encoding the amyloid protein precursor or on chromosomes 14 or 1 encoding genes known as presenilins. All mutations examined have been found to increase the p...

journal_title：Neurochemical research

authors： Small DH

更新日期：1998-05-01 00:00:00

abstract：:The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...

journal_title：Neurochemical research

authors： Xie J,Han F,Shi Y

更新日期：2014-04-01 00:00:00

abstract：:Mice infected with the Venezuelan equine encephalomyelitis virus showed a significant decrease in the GABA content of cerebral hemispheres. Activity of the enzyme which synthetizes GABA, glutamate decarboxylase, is also reduced in whole cerebral hemispheres, neostriatum, and frontal cortex of infected animals, as comp...

journal_title：Neurochemical research

authors： Bonilla E,Ryder E,Ryder S

更新日期：1980-02-01 00:00:00

abstract：:The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebe...

journal_title：Neurochemical research

authors： López-Colomé AM,Ortega A

更新日期：1997-06-01 00:00:00

abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...

journal_title：Neurochemical research

authors： Grove J,Kentroti S,Prasad K,Vernadakis A

更新日期：1997-03-01 00:00:00