Binding of [3H]muscimol to calf cerebrocortical synaptic membranes and the effects of sulphur-containing convulsant and non-convulsant compounds.

abstract：:The expression and localization of syntaxin isoforms 1A and 1B in adrenergic and noradrenergic chromaffin cells were examined by both immunoblot analysis and confocal immunofluorescence microscopy. Syntaxin 1A was found in higher levels in noradrenergic cells, whereas syntaxin 1B was similarly expressed in most noradr...

journal_title：Neurochemical research

authors： Baltazar G,Carvalho AP,Duarte EP

更新日期：2003-10-01 00:00:00

abstract：:The influence of hypothyroidism (HO) induced by treatment with propylthiouracil on lipid composition, receptor responsiveness of M1-muscarinic receptors (M1AChRs) and metabotropic glutamate receptors (mGluRs) as well as on protein kinase C (PKC) activity was investigated in the cerebral cortex of Lewis rats. HO did no...

journal_title：Neurochemical research

authors： Pintor A,Fortuna S,Lorenzini P,Pascale A,Battaini F,Avellino C,Malvezzi Campeggi L,Salvati S

更新日期：1996-05-01 00:00:00

abstract：:Fecal incontinence and constipation still remain the major complications after procedures for anorectal malformations (ARMs). Previous studies have demonstrated a decrease of neural cell in lumbosacral spinal cord of ARMs patients and rat models. However, the underlying mechanism remains elusive. In this study, the ne...

journal_title：Neurochemical research

authors： Yang Z,Geng Y,Yao Z,Jia H,Bai Y,Wang W

更新日期：2017-11-01 00:00:00

abstract：:Treatment for epilepsy, particularly temporal lobe epilepsy, is challenging. Baicalein has multiple effects, including anti-inflammatory action. However, little is known about its efficacy in treatment of epilepsy. In this study, we established a pilocarpine-induced rat model and used it for assessment of baicalein ef...

journal_title：Neurochemical research

authors： Fu P,Yuan Q,Sun Y,Wu X,Du Z,Li Z,Yu J,Lv K,Hu J

更新日期：2020-12-01 00:00:00

abstract：:The central control of growth hormone (GH) secretion from the pituitary gland is ultimately achieved by the interaction between two hypothalamic neurohormones, somatostatin which inhibits and growth hormone-releasing hormone (GHRH) which stimulates GH release. The regulation of the somatostatin and GHRH release from t...

journal_title：Neurochemical research

authors： Fodor M,Kordon C,Epelbaum J

更新日期：2006-02-01 00:00:00

abstract：:The SAM strains, a group of related inbred strains consisting of senescence-prone inbred strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully developed by selective inbreeding of the AKR/J strain of mice donated by the Jackson laboratory in 1968. The characteristic feature of aging com...

journal_title：Neurochemical research

authors： Takeda T

更新日期：2009-04-01 00:00:00

abstract：:The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...

journal_title：Neurochemical research

authors： de Fiebre CM,Wu P,Notabartolo D,Millard WJ,Meyer EM

更新日期：1994-06-01 00:00:00

abstract：:The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...

journal_title：Neurochemical research

authors： Pei DS,Sun YF,Song YJ

更新日期：2009-08-01 00:00:00

abstract：:Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...

journal_title：Neurochemical research

authors： Neidle A,Manigault I,Wajda IJ

更新日期：1979-06-01 00:00:00

abstract：:The effects of acute lorazepam challenges on plasma (p) HVA, MHPG, and 5-HIAA, and their relationship to drug-induced cognitive and motor deficits and the apolipoprotein (APOE)-epsilon4 allele were examined. Eighteen healthy elderly (8 epsilon4 carriers) received placebo or acute oral lorazepam doses (0.5 mg or 1 mg) ...

journal_title：Neurochemical research

authors： Pomara N,Willoughby LM,Hashim A,Sershen H,Sidtis JJ,Wesnes K,Greenblatt DJ,Lajtha A

更新日期：2004-07-01 00:00:00

abstract：:Oxidative stress is a long-hypothesized cause of diverse neurological and psychiatric disorders but the pathways by which physiological redox perturbations may detour healthy brain development and aging are unknown. We reported recently (Foley et al., Neurochem Res 39:2030-2039, 2014) that two-electron oxidations, to ...

journal_title：Neurochemical research

authors： Foley TD,Katchur KM,Gillespie PF

更新日期：2016-10-01 00:00:00

abstract：:Metal ions are often used to block calcium channels in various tissues, including synaptosomes. In the present study, Fura-2 was used to determine the effectiveness of various metal ions as calcium channel blockers in rat brain synaptosomes in vitro. In buffer solutions, La3+ and Cd2+ increased the Fura-2 fluorescence...

journal_title：Neurochemical research

authors： Sun YD,Benishin CG

更新日期：1989-11-01 00:00:00

abstract：:This study was undertaken to evaluate whether chemical hypoxia-induced cell injury is a result of reactive oxygen species (ROS) generation, ATP depletion, mitochondrial permeability transition, and an increase in intracellular Ca2+, in A172 cells, a human glioma cell line. Chemical hypoxia was induced by incubating ce...

journal_title：Neurochemical research

authors： Jeong JI,Lee YW,Kim YK

更新日期：2003-08-01 00:00:00

abstract：:Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...

journal_title：Neurochemical research

authors： Sitges M,Aldana BI,Reed RC

更新日期：2016-06-01 00:00:00

abstract：:In the experimental setting, taurine is known to be released from swollen cells to reestablish their normal volume. However, its clinical relevance has not been fully understood. This study was undertaken to reveal changes in cerebrospinal fluid (CSF) amino acids concentration in patients with severe traumatic brain i...

journal_title：Neurochemical research

authors： Seki Y,Kimura M,Mizutani N,Fujita M,Aimi Y,Suzuki Y

更新日期：2005-01-01 00:00:00

abstract：:McGill-R-Thy1-APP rats express the human amyloid precursor protein carrying the Swedish and Indiana mutations. We examined the neurochemical content of the dorsal hippocampus in three-months-old male and female transgenic rats and healthy age- and gender-matched controls using in vivo (1)H MRS in order to assess early...

journal_title：Neurochemical research

authors： Nilsen LH,Melø TM,Witter MP,Sonnewald U

更新日期：2014-02-01 00:00:00

abstract：:Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...

journal_title：Neurochemical research

authors： Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

更新日期：2019-04-01 00:00:00

abstract：:The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undert...

journal_title：Neurochemical research

authors： Kar F,Hacioglu C,Uslu S,Kanbak G

更新日期：2019-08-01 00:00:00

abstract：:The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...

journal_title：Neurochemical research

authors： Nakajima T

更新日期：1996-02-01 00:00:00

abstract：:There is increasing evidence that proteins normally involved in the cell cycle play a role in the regulation of neuronal apoptotic death following various insults. However, it is not clear if the same mechanisms regulate cell death of oligodendrocytes as well. In this study, we investigated the mechanism of ceramide-i...

journal_title：Neurochemical research

authors： Strazza M,Luddi A,Brogi A,Carbone M,Riccio M,Santi S,Melli M,Costantino-Ceccarini E

更新日期：2004-05-01 00:00:00

abstract：:Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%, daily, for 21 days) o...

journal_title：Neurochemical research

authors： Hritcu L,Bagci E,Aydin E,Mihasan M

更新日期：2015-09-01 00:00:00

abstract：:It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...

journal_title：Neurochemical research

authors： Espinosa de los Monteros A,Kumar S,Zhao P,Huang CJ,Nazarian R,Pan T,Scully S,Chang R,de Vellis J

更新日期：1999-02-01 00:00:00

abstract：:Cathepsin B (EC 3.4.22.1) was purified 746-fold with a 21% recovery from bovine brain by autolysis, fractional precipitation with acetone, carboxy-methyl-Sephadex chromatography, affinity chromatography on a cystamine containing column and gel filtration chromatography. The purified cathepsin B eluted on gel filtratio...

journal_title：Neurochemical research

authors： Bradley JD,Whitaker JN

更新日期：1986-06-01 00:00:00

abstract：:Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria-nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from huma...

journal_title：Neurochemical research

authors： Suneetha LM,Satish PR,Korula RJ,Suneetha SK,Job CK,Balasubramanian AS

更新日期：1998-06-01 00:00:00

abstract：:Hyperprolinemia type II (HPII) is an autosomal recessive disorder caused by the severe deficiency of enzyme delta1-pyrroline-5-carboxylic acid dehydrogenase leading to tissue accumulation of proline. Chronic administration of Pro led to significant reduction of cytosolic ALT activity of olfactory lobes (50.57%), cereb...

journal_title：Neurochemical research

authors： Shanti ND,Shashikumar KC,Desai PV

更新日期：2004-12-01 00:00:00

abstract：:We investigated the ability of hydrogen peroxide (H2O2) to cause apoptotic cell death in cultured rat forebrain neurons and the potential mechanisms by which oxidative stress triggers delayed neuronal death. H2O2 (25 microM for 5 min) reduced cell viability to 34.5 +/- 8.3% of untreated controls 20 h after exposure, a...

journal_title：Neurochemical research

authors： Hoyt KR,Gallagher AJ,Hastings TG,Reynolds IJ

更新日期：1997-03-01 00:00:00

abstract：:The search for neuronotrophic factors addressing CNS neurons requires CNS neuronal cell cultures to quantitate putative effects on neuronal survival. Investigation of neurons dissociated from several embryonic CNS tissues have shown that their short-term survival requires supplementation of the culture medium with eit...

journal_title：Neurochemical research

authors： Chau RM,Skaper SD,Varon S

更新日期：1988-07-01 00:00:00

abstract：:Mice with a heterozygous knock-out of the myelin protein P0 gene (P0+/-) develop a neuropathy similar to human Charcot-Marie-Tooth disease. They are indistinguishable from wild-types (WT) at birth and develop a slowly progressing demyelinating neuropathy. The aim of this study was to investigate whether the regenerati...

journal_title：Neurochemical research

authors： Rosberg MR,Alvarez S,Krarup C,Moldovan M

更新日期：2013-06-01 00:00:00

abstract：:Neuronal differentiation and aging are known to involve many genes, which may also be differentially expressed during these developmental processes. From primary cultured cerebral cortical neurons, we have previously identified various differentially expressed gene transcripts from cultured cortical neurons using the ...

journal_title：Neurochemical research

authors： Yu AC,Sun CX,Li Q,Liu HD,Wang CR,Zhao GP,Jin M,Lau LT,Fung YW,Liu S

更新日期：2005-10-01 00:00:00

abstract：:Folic acid plays an important role in neuroplasticity and acts as a neuroprotective agent, as observed in experimental brain ischemia studies. The aim of this study was to investigate the effects of folic acid on locomotor activity, aversive memory and Na(+),K(+)-ATPase activity in the frontal cortex and striatum in a...

journal_title：Neurochemical research

authors： Carletti JV,Deniz BF,Miguel PM,Rojas JJ,Kolling J,Scherer EB,de Souza Wyse AT,Netto CA,Pereira LO

更新日期：2012-08-01 00:00:00