Abstract:
:The central control of growth hormone (GH) secretion from the pituitary gland is ultimately achieved by the interaction between two hypothalamic neurohormones, somatostatin which inhibits and growth hormone-releasing hormone (GHRH) which stimulates GH release. The regulation of the somatostatin and GHRH release from the hypothalamus is regulated by a range of other neuropeptides, neurotransmitters, neurohormones. In this mini review we attempt to provide a short summary covering the anatomy and chemical characteristics of the various cell populations regulating GH secretion as a tribute to Miklós Palkovits who pioneered the field of functional neuroanatomy of hypothalamic networks.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Fodor M,Kordon C,Epelbaum Jdoi
10.1007/s11064-005-9017-3keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
137-43issue
2eissn
0364-3190issn
1573-6903journal_volume
31pub_type
杂志文章,评审abstract::Evidence is presented that multiple forms of cyclic nucleotide phophodiesterase (PDE) activity chromatographically separated from the soluble fraction of bovine hypothalamus are co-eluted with multiple forms of 5'-nucleotidase (5'N) activity. The enzymes could not be resolved from each other by anion-exchange chromato...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965512
更新日期:1989-12-01 00:00:00
abstract::The microdialysis technique was used to study the effect of nitric oxide synthase (NOS) activity on taurine release. Taurine release was characterized in rat striatum that was excitotoxically lesioned compared to normal conditions. The basal taurine level of the dialysate decreased during quinolinate (QUIN) lesion in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022418231496
更新日期:1998-04-01 00:00:00
abstract::It is an honour to have this opportunity write an article in recognition of the immense contributions of Bruce Ransom to the field of glial research. For me (BAM) personally there are many highlights both as a colleague and a friend that come to mind when I reflect on the many years that I have known Bruce. My own ent...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-017-2315-8
更新日期:2017-09-01 00:00:00
abstract::Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022421001288
更新日期:2003-02-01 00:00:00
abstract::Several studies showed that the up-regulation of glial glutamate transporter-1 (GLT-1) participates in the acquisition of brain ischemic tolerance induced by cerebral ischemic preconditioning or ceftriaxone pretreatment in rats. To explore whether GLT-1 plays a role in the acquisition of brain ischemic tolerance induc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0639-3
更新日期:2012-03-01 00:00:00
abstract::The δ subunit of the GABAAR is highly expressed in the dentate gyrus of the hippocampus where it mediates a tonic extrasynaptic inhibitory current that is sensitive to neurosteroids. In female mice, the expression level of the δ subunit within the dentate gyrus is elevated in the diestrous relative to estrous phase of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1282-6
更新日期:2014-06-01 00:00:00
abstract::The present investigation evaluates the anti-stress activity of risperidone (RIS) in the cold restraint stress (CRS) model and related stress pathways. Rats were pretreated with RIS (0.1 and 1.0 mg/kg) for 21 days before subjecting to CRS. Ultra low dose of RIS (ULD; 0.1 mg/kg) in contrast to higher dose (1.0 mg/kg) s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0490-6
更新日期:2011-10-01 00:00:00
abstract::A case-control study was undertaken to investigate the status of platelet monoamine oxidase-B (MAO-B) activity in Indian cases of idiopathic Parkinson's disease. A significant increase in the activity of platelet MAO-B was observed in Parkinson's cases (n = 26) as compared to controls (n = 26). No significant change i...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9929-4
更新日期:2009-08-01 00:00:00
abstract::We have previously shown that extracellular ATP caused cell death in PC12 cells through activation of its receptors. Oxidative stress has been implicated as a mechanism of cell death caused by extracellular ATP. In the present study we examined the possible signal transduction cascades leading to cell death by extrace...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022438703271
更新日期:1998-04-01 00:00:00
abstract::The effects of phenylalanine (PHE) and its deaminated metabolites phenylpyruvate (PHP), phenyllactate (PHL) and phenylacetate (PHA) on sodium and potassium activated adenosinetriphosphatase (Na+,K+-ATPase) in synaptosomes from rat brain were investigated. At very low concentrations (5-10 microM). PHE, PHL and PHA inhi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965524
更新日期:1982-06-01 00:00:00
abstract::It has been established that oligodendrocytes, the myelin forming cells, participate in iron homeostasis through the synthesis and secretion of transferrin. Here we investigated whether a correlation exists between myelination, the commonly studied function of oligodendrocytes, and that of transferrin synthesis and se...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-004-1826-2
更新日期:1999-02-01 00:00:00
abstract::This study investigated the effects of aging on the actions of a specific glutamate reuptake blocker, L-trans-pyrrolidine-2, 4-dicarboxylic acid (PDC), in extracellular glutamate and glutamine in striatum of the awake rat. Microdialysis experiments were performed on young (2-3 months), middle-aged (12-14 months), aged...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007624531077
更新日期:2001-01-01 00:00:00
abstract::Hypoxia is one of the major common components of vascular risk factors for pathogenesis of Alzheimer's disease. This study investigated the possible relationship between hypoxia and alternative splicing of the excitatory amino acid transporter 2 (EAAT2) in a transgenic model for Alzheimer's disease. We used an APP23 m...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9540-5
更新日期:2008-06-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-016-1829-9
更新日期:2016-06-01 00:00:00
abstract::Niemann-Pick disease type C (NPC) is a neurovisceral disorder characterized by lysosomal sequestration of endocytosed LDL-cholesterol, premature and abnormal enrichment of cholesterol in trans Golgi cisternae and accompanying anomalies in intracellular sterol trafficking. In addition to cholesterol, the NPC lesion has...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1022575511354
更新日期:1999-04-01 00:00:00
abstract::The modulation of intracellular GABA activated 36Cl- in-->out permeation across single Deiters' neuron membranes has been studied in a microchamber system. Addition of Mg2+/ATP on the membrane cytoplasmic side reduces strongly the GABA effect as does ATP alone. However, the greatest inhibition of the GABA effect is gi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021073230464
更新日期:1999-08-01 00:00:00
abstract::The mortality of patients with malignant gliomas remains high despite the advancement in multi-modal therapy including surgery, radio- and chemotherapy. Glioma stem cells (GSCs), sharing some characteristics with normal neural stem cells (NSCs), contribute to the cellular origin for primary gliomas and the recurrence ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-012-0879-x
更新日期:2012-12-01 00:00:00
abstract::The phospholipid requirement for Ca2+-stimulated, Mg2+-dependent ATP hydrolysis (Ca2+/Mg2+-ATPase) and Mg2+-stimulated ATP hydrolysis (Mg2+-ATPase) in rat brain synaptosomal membranes was studied employing partial delipidation of the membranes with phospholipase A2 (Hog pancreas), phospholipase C (Bacillus cereus) and...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966224
更新日期:1986-10-01 00:00:00
abstract::To assess the therapeutic effects of microRNA-21 (miR-21) knockdown (KD) for acute thoracic spinal cord contusion using a mouse model. Forty C57/BL6 mice were randomly divided into four groups: mice in the sham-operated (Sham) group received surgical procedure without spinal cord contusion; the spinal cord injury (SCI...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2580-1
更新日期:2018-08-01 00:00:00
abstract::Disturbance in cholesterol homeostasis appears to be an important factor in the pathogenesis of neurodegenerative disorders. The aim of the present study was to investigate sterol regulatory element binding protein (SREBP) levels in the nuclear extracts of human neuroblastoma cells and the possible interaction of beta...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9832-4
更新日期:2009-05-01 00:00:00
abstract::The endogenous sialidase (N-acetylneuraminidase) activity of membranes prepared from goldfish retina and optic tectum displays characteristics similar to those reported for neural plasma membrane sialidases of other organisms. Endogenous membrane sialidase activity was found to be optimal at ph 4.0, and maximal releas...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965657
更新日期:1983-01-01 00:00:00
abstract::The number of c-Fos protein-like immunoreactive (c-Fos-IR) neurons in the spinal dorsal horn evoked by noxious stimulation was previously shown to be increased following peripheral nerve injury, and this increase was proposed to reflect the neuropathic pain state. The aim of this study was to investigate whether anoma...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1484-y
更新日期:2015-03-01 00:00:00
abstract::The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate. Caspase-independent death caused by high levels of NO is also partially prevented by 8-Br-cGMP. Inhibitors of protein kinase G (cGM...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-006-9187-7
更新日期:2007-02-01 00:00:00
abstract::Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%, daily, for 21 days) o...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1662-6
更新日期:2015-09-01 00:00:00
abstract::Experimental studies demonstrate that inhaled anesthetics can cause neurodegeneration and neurobehavioral dysfunctions. Evidence suggests changes in cerebral metabolism following inhaled anesthetics treatment can perturb cerebral homeostasis, which may be associated with their induced neurotoxicity. Seven-day-old rat ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1529-x
更新日期:2015-04-01 00:00:00
abstract::This review summarizes the recent research development on mammalian sialidase molecular cloning. Sialic acid-containing compounds are involved in several physiological processes, and sialidases, as glycohydrolytic enzymes that remove sialic acid residues, play a pivotal role as well. Sialidases hydrolyze the nonreduci...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1023/a:1020276000901
更新日期:2002-08-01 00:00:00
abstract::An in vitro model of anoxia-induced brain damage was utilized to help elucidate the biochemical basis of cell damage due to reduced oxygen availability. Previous studies suggest that anoxia-induced damage may vary presynaptically, post-synaptically or in the cell body. Thus, the consequences of an anoxic treatment inc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972482
更新日期:1988-04-01 00:00:00
abstract::We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00975043
更新日期:1993-12-01 00:00:00
abstract::This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00969761
更新日期:1989-01-01 00:00:00
abstract::The anterograde axonal transport of choline-phosphoglycerides was studied in sciatic nerve motoneurons of adult (3-month-old) and aged (24-month-old) rats. After the spinal cord injection of [2-3H]glycerol, choline-phosphoglycerides; the major phospholipid class was transported along the nerve. The axonal transport ra...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971365
更新日期:1987-01-01 00:00:00