Abstract:
:This review summarizes the recent research development on mammalian sialidase molecular cloning. Sialic acid-containing compounds are involved in several physiological processes, and sialidases, as glycohydrolytic enzymes that remove sialic acid residues, play a pivotal role as well. Sialidases hydrolyze the nonreducing, terminal sialic acid linkage in various natural substrates, such as glycoproteins, glycolipids, gangliosides, and polysaccharides. Mammalian sialidases are present in several tissues/organs and cells with a typical subcellular distribution: they are the lysosomal, the cytosolic, and the plasma membrane-associated sialidases. Starting in 1993, 12 different mammalian sialidases have been cloned and sequenced. A comparison of their amino acid sequences revealed the presence of highly conserved regions. These conserved regions are shared with viral and microbial sialidases that have been characterized at three-dimensional structural level, allowing us to perform the molecular modeling of the mammalian proteins and suggesting a monophyletic origin of the sialidase enzymes. Overall, the availability of the cDNA species encoding mammalian sialidases is an important step leading toward a comprehensive picture of the relationships between the structure and biological function of these enzymes.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Monti E,Preti A,Venerando B,Borsani Gdoi
10.1023/a:1020276000901keywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
649-63issue
7-8eissn
0364-3190issn
1573-6903journal_volume
27pub_type
杂志文章,评审abstract::Disturbance in cholesterol homeostasis appears to be an important factor in the pathogenesis of neurodegenerative disorders. The aim of the present study was to investigate sterol regulatory element binding protein (SREBP) levels in the nuclear extracts of human neuroblastoma cells and the possible interaction of beta...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9832-4
更新日期:2009-05-01 00:00:00
abstract::Acrylamide, a prototype neurotoxin, alters neurofilament protein (NF) gene expression in rat brain. Levels of mRNA coding for neurofilament protein subunits NF-L, NF-M, and NF-H have been determined by Northern blot analysis using 32P-labeled cDNA probes. Acrylamide given acutely (100 mg/kg, single intraperitoneal inj...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967449
更新日期:1994-07-01 00:00:00
abstract::Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1609-y
更新日期:2017-01-01 00:00:00
abstract::The K-stimulated release of [3H]ACh from rat midbrain slices prelabeled by incubation with [3H]choline was dependent on extracellular Ca. Phenobarbital inhibited the K-stimulated [3H]ACh release and the IC50 was equal to that found for K-stimulated endogenous ACh release. These results support the suggestion that barb...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964710
更新日期:1980-07-01 00:00:00
abstract::Altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of Alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adapt...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-018-2469-z
更新日期:2018-03-01 00:00:00
abstract::Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX2 in this effect has not been illuminated. So this study explored the role of NOX2 in TBI models treated with DHA, aiming to complete the mechanism of DHA...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03078-z
更新日期:2020-08-01 00:00:00
abstract::Astrocytes occupy a strategic position in the brain where they can act as an interface between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This location is ideal for functioning as interoceptors, as they may sense changes in brain microenvironment and contribute to the adaptive homeostatic r...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1562-9
更新日期:2015-12-01 00:00:00
abstract::Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964958
更新日期:1980-12-01 00:00:00
abstract::Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-02969-5
更新日期:2020-04-01 00:00:00
abstract::The characteristics of endogenous Ca2+/calmodulin (CaM)- and Ca2+/phosphatidylserine (PS)-stimulated phosphorylated proteins in the striatum of rat were partially determined and compared in this study. The Ca2+/CaM-dependent phosphoproteins were associated with serine and threonine residues. The sensitivity of these p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968670
更新日期:1990-03-01 00:00:00
abstract::This investigation was performed to evaluate the effects of ACPD [(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid], a metabotropic glutamate receptor agonist, on cerebral O2 consumption during focal cerebral ischemia. Male Wistar rats were placed in control (n = 7) and ACPD (n = 7) groups under isoflurane anesthesia...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1026159422237
更新日期:2003-12-01 00:00:00
abstract::3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9904-5
更新日期:2009-07-01 00:00:00
abstract::Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the nervous system. We have now investigated the pattern of adenosine formation with different concentrations of extracellular ATP in rat hippocampal nerve terminals. It was found that adenosine...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1012392719601
更新日期:2001-09-01 00:00:00
abstract::Ion fluxes in mammalian myelinated axons are restricted to the nodes of Ranvier, where, in particular, voltage-gated Na+ channels are clustered at a high density. The node of Ranvier is separated from the internode by two distinct domains of the axolemma, the paranode and the juxtaparanode. Each axonal domain is chara...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1021608514646
更新日期:2003-01-01 00:00:00
abstract::The composition of retrogradely transported axonal proteins was examined by acrylamide gel electrophoresis and gel autoradiography in the experimental neuropathy induced in rats by p-bromophenylacetylurea (BPAU). Protein composition was normal during the early phase of retrograde transport but showed significant abnor...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966781
更新日期:1993-06-01 00:00:00
abstract::Single exposure of adult male rats to low environmental temperature (LET, 12 +/- 0.5 degrees C) for 2 h significantly increased the hypothalamic and striatal GABA levels without affecting those in other regions of brain. The activity of glutamate decarboxylase (GAD) was elevated in hypothalamus (H) and corpus striatum...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00968559
更新日期:1990-08-01 00:00:00
abstract::Parkinson's disease (PD) is a common progressive neurodegenerative disorder, for which at present no causal treatment is available. On the understanding that the causes of PD are mainly oxidative stress and mitochondrial dysfunction, antioxidants and other drugs are expected to be used. In the present study, we demons...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-0046-1
更新日期:2010-02-01 00:00:00
abstract::The kinetics and specificity of taurine and beta-alanine uptake were studied in primary cultures of rat astrocytes under identical experimental conditions. The uptake consisted of nonsaturable penetration and saturable high-affinity transport that was strictly sodium dependent. The cells accumulated taurine more effec...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967969
更新日期:1986-02-01 00:00:00
abstract::Tetrahydrobiopterin and the folate coenzymes can reciprocally interact in ways that would be useful to the metabolic pathways subserved by both of these coenzymes. Thus, through one of the reactions catalyzed by methylene tetrahydrofolate reductase, 5-CH3-H4-folate can regenerate BH4 from q-BH2 and q-BH2 can provide a...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF00965847
更新日期:1991-09-01 00:00:00
abstract::Convulsant doses of penicillin and elevated ambient pressure of 41 bar enhance the excitability of neurons. Their effects have been studied in neostriatal tissue with methods allowing differentiation between transmitter and metabolic glutamate pools. Levels of glutamate (Glu), glutamine (Gln), aspartate (Asp); gamma-a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965621
更新日期:1989-11-01 00:00:00
abstract::Emerging data suggests that mitochondrial dysfunction is prominently involved in Alzheimer disease (AD) progression. Sirtuin-3 (Sirt3) is a member of the sirtuin family of nicotinamide adenine dinucleotide dependent deacetylases that regulates a variety of mitochondrial functions and suppresses mitochondria-related ph...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1630-1
更新日期:2015-08-01 00:00:00
abstract::Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Here, the effect of proteasome inhibition on the morphology of cultured rat cortical astrocytes was investigated. Increasing evidence suggests that the function of astrocytes is related close...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9830-6
更新日期:2009-05-01 00:00:00
abstract::The synaptic glutamate level homeostasis is mainly maintained by the astrocytes membrane bound glutamate transporter type-1 (GLT-1/EAAT2). Alterations in its expression during development and aging and the underlying mechanisms are not well studied. Here, we report that NF-κB interaction was highest in both cerebral a...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1200-3
更新日期:2014-01-01 00:00:00
abstract::28-O-caffeoyl betulin (B-CA) has been demonstrated to reduce the cerebral infarct volume caused by transient middle cerebral artery occlusion (MCAO) injury. B-CA is a novel derivative of naturally occurring caffeoyl triterpene with little information associated with its pharmacological target(s). To date no data is av...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-020-03202-z
更新日期:2021-01-03 00:00:00
abstract::Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964537
更新日期:1985-06-01 00:00:00
abstract::The Wistar-Kyoto (WKY) rat strain has been described as an animal model of depressive behavior that consumes significantly greater amounts of alcohol compared to the Wistar (WIS) rat strain. Since the mesolimbic dopamine (DA) type-2 (D2) receptors mediate reward-related behaviors, the present study measured the bindin...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0233-0
更新日期:2010-11-01 00:00:00
abstract::Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0327-8
更新日期:2011-02-01 00:00:00
abstract::The axonal transport of tRNA has been investigated in the chick optic system. Chicks were injected with [3H]uridine intraocularly or intracranially and the RNA of the retina, nerve complex, and tecta separated by polyacrylamide gel electrophoresis and then counted. The ratio of tRNA to rRNA specific activities increas...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966323
更新日期:1978-08-01 00:00:00
abstract::Nicotinic agonists stimulate 22Na flux in rat pheochromocytoma PC12 cells. The stimulatory effect of carbamylcholine is maximal at 1 mM, while the stimulatory effect of nicotine and anatoxin maximize at the same level at 100 microM and 10 microM, respectively. The tertiary amines arecolone and isoarecolone have no eff...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965571
更新日期:1991-04-01 00:00:00
abstract::Antidepressive drugs offer considerable symptomatic relief in mood disorders and, although commonly discovered by screening with single biological targets, most interact with multiple receptors and signaling pathways. Antidepressants require a treatment regimen of several weeks before clinical efficacy is achieved in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-8513-9
更新日期:2005-11-01 00:00:00