Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain.

abstract：:Alzheimer's disease (AD) is the most common form of dementia that progressively disrupts neurocognitive function, which has neither cure nor effective treatment. Hypercholesterolemia might be involved in brain alterations that could evolve into AD. The present study aims to evaluate the potential of omega-3, Co-enzyme...

journal_title：Neurochemical research

authors： Ibrahim Fouad G

更新日期：2020-05-01 00:00:00

abstract：:The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applicat...

journal_title：Neurochemical research

authors： Dinh L,Nguyen T,Salgado H,Atzori M

更新日期：2009-11-01 00:00:00

abstract：:The binding of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) is characterized by its high affinity for receptors on NG108-15 hybrid cells, the affinity constant K = 4.7 X 10(9) M-1 is up to 8-fold that of monomers (0.6 to 1.0 X 10(9) M-1), and a maximal binding capacity equal to one half that of the monomers. Ki...

journal_title：Neurochemical research

authors： Krumins SA,Lutz RA,Costa T,Rodbard D

更新日期：1986-06-01 00:00:00

abstract：:Evidence is presented in support of the working hypothesis that "prenervous" neurotransmitters directly participate in cell-cell interactions occurring during the first several cleavage divisions of sea urchin embryos, a function which may occur during the early development of higher animals as well. This intercellula...

journal_title：Neurochemical research

authors： Buznikov GA,Shmukler YB

更新日期：1981-01-01 00:00:00

abstract：:The diversification of neuronal subtypes during corticogenesis is fundamental to the establishment of the complex cortical structure. Although subtype specification has been assumed to occur in neural progenitor cells, increasing evidence has begun to reveal the plasticity of subtype determination in immature neurons....

journal_title：Neurochemical research

authors： Oishi K,Nakajima K

更新日期：2018-01-01 00:00:00

abstract：:Mutations in presenilin 1 (PS-1) are associated with most early-onset familiar Alzheimer's disease (AD). Previous studies have demonstrated that PS-1 mutations enhance the production of beta-amyloid (Aβ). In this study, we further examined the in vivo effects of PS-1 mutation on tau and synapse protein markers. The da...

journal_title：Neurochemical research

authors： Yang X,Yang Y,Liu J,Li G,Yang E

更新日期：2012-01-01 00:00:00

abstract：:Members of the PDGF family have multiple roles during embryogenesis and in a variety of pathological situations in the adult. One of the major sites of PDGF-B expression in adult mammals are postmitotic CNS neurons. Combined with reported neurotrophic and neuroprotective effects of exogenously administered PDGFs, this...

journal_title：Neurochemical research

authors： Enge M,Wilhelmsson U,Abramsson A,Stakeberg J,Kühn R,Betsholtz C,Pekny M

更新日期：2003-02-01 00:00:00

abstract：:There is increasing evidence to suggest that hepatic encephalopathy in acute liver failure is the result of altered glutamatergic function. In particular, the high affinity uptake of glutamate is decreased in brain slices and synaptosomes from rats with acute liver failure as well as by exposure of cultured astrocytes...

journal_title：Neurochemical research

authors： Chan H,Butterworth RF

更新日期：1999-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common neurodegenerative condition that affects the elderly population. Its primary symptom is memory loss. The memory dysfunction in AD has been associated with cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM). Zizyphus jujube (ZJ) a...

journal_title：Neurochemical research

authors： Rabiei Z,Rafieian-Kopaei M,Heidarian E,Saghaei E,Mokhtari S

更新日期：2014-02-01 00:00:00

abstract：:Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. However, therapeutic strategies against malignant gliomas have not been completely established. Runt-related transcription factor 2 (Runx2) is an essential gene for skeletal development but its regulatory role in the malignant progression of gli...

journal_title：Neurochemical research

authors： Yamada D,Fujikawa K,Kawabe K,Furuta T,Nakada M,Takarada T

更新日期：2018-11-01 00:00:00

abstract：:The human formyl peptide receptor like 1 (FPRL-1) is a variant of the Gi-coupled formyl-peptide receptor. Functional FPRL-1 is endogenously expressed in the U87 astrocytoma cell line and there is accumulating evidence to suggest that FPRL-1 may be involved in neuroinflammation associated with the pathogenesis of Alzhe...

journal_title：Neurochemical research

authors： Kwan DH,Kam AY,Wong YH

更新日期：2008-01-01 00:00:00

abstract：:2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...

journal_title：Neurochemical research

authors： Lanning CL,Wilmarth KR,Abou-Donia MB

更新日期：1994-09-01 00:00:00

abstract：:The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the n...

journal_title：Neurochemical research

authors： Serra I,Cupello A,Gadaleta MN,Viola M,Ragonese P,Giuffrida AM

更新日期：1983-04-01 00:00:00

abstract：:Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three...

journal_title：Neurochemical research

authors： Simon JR,Oderfeld-Nowak B,Felten DL,Aprison MH

更新日期：1981-05-01 00:00:00

abstract：:Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...

journal_title：Neurochemical research

authors： Jiang B,Song L,Huang C,Zhang W

更新日期：2016-05-01 00:00:00

abstract：:Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce informa...

journal_title：Neurochemical research

authors： Rojas DB,Gemelli T,de Andrade RB,Campos AG,Dutra-Filho CS,Wannmacher CM

更新日期：2012-05-01 00:00:00

abstract：:Synaptosomal membrane proteins solubilized with 8% CHAPS-8 M urea were analyzed with two-dimensional electrophoresis (2DE). The membrane proteins were resolved up to 250 spots on a 2DE map, ranging in isoelectric points (pI) from 3.5 to 10.0 and molecular weights (MW) from 10 kDa to 200 kDa. Comparison of the mapped p...

journal_title：Neurochemical research

authors： Ishioka N,Oda T,Natake Y,Kurioka S

更新日期：1990-05-01 00:00:00

abstract：:Deposition of amyloid beta peptide in human brain in the form of senile plaques is a neuropathological hallmark of Alzheimer's disease (AD). Levels of a phospholipid breakdown product, glycerophosphocholine (GPC), also increase in AD brain. The effect of GPC on amyloid beta(1-40) peptide (Abeta) aggregation in PBS buf...

journal_title：Neurochemical research

authors： Mandal PK,McClure RJ,Pettegrew JW

更新日期：2004-12-01 00:00:00

abstract：:In order to obtain further evidence of putative neurotransmitters in primary sensory neurons and interneurons in the dorsal spinal cord, we have studied the effects of unilateral section of dorsal roots and unilateral occlusion of the dorsal spinal artery on cholinergic enzyme activity and on selected amino acid level...

journal_title：Neurochemical research

authors： Fujita K,Nagata Y

更新日期：1989-05-01 00:00:00

abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...

journal_title：Neurochemical research

authors： Bates DJ,Sirkos S,Moses EK,Austin L

更新日期：1983-03-01 00:00:00

abstract：:The pineal gland is a neuroendocrine gland responsible for nocturnal synthesis of melatonin. During early development of the rodent pineal gland from the roof of the diencephalon, homeobox genes of the orthodenticle homeobox (Otx)- and paired box (Pax)-families are expressed and are essential for normal pineal develop...

journal_title：Neurochemical research

authors： Rath MF,Rohde K,Klein DC,Møller M

更新日期：2013-06-01 00:00:00

abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...

journal_title：Neurochemical research

authors： Grove J,Kentroti S,Prasad K,Vernadakis A

更新日期：1997-03-01 00:00:00

abstract：:Evidence suggests that apoptosis contributes significantly to cell death after cerebral ischemia. Our recent studies that utilized human umbilical cord blood-derived mesenchymal stem cells (hUCBSCs) demonstrated the potential of hUCBSCs to inhibit neuronal apoptosis in a rat model of CNS injury. Therefore, we hypothes...

journal_title：Neurochemical research

authors： Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Veeravalli KK

更新日期：2014-08-01 00:00:00

abstract：:The present study investigated the expression patterns of glial cells and interleukin-1beta (IL-1beta) in the rat spinal cord after a surgical incision, which is closely related with clinical postoperative pain. Microglia and astrocytes became activated in the spinal cord following incision. Real-time polymerase chain...

journal_title：Neurochemical research

authors： Fu D,Guo Q,Ai Y,Cai H,Yan J,Dai R

更新日期：2006-03-01 00:00:00

abstract：:Exposure of rat pheochromocytoma PC12 cells to 0.1 mM 6-aminonicotinamide (6AN) for 24 hours resulted in a 500-fold increase in 6-phosphogluconate indicating active metabolism of glucose via the oxidative enzymes of the pentose phosphate pathway. Amounts of 6-phosphogluconate that accumulated in 6AN-treated cells at 2...

journal_title：Neurochemical research

authors： Davis LH,Kauffman FC

更新日期：1987-06-01 00:00:00

abstract：:Recent studies provide solid evidence for the importance to delineate the co-relationship between preconditioning stimuli and therapeutic efficacy of drugs commonly used in clinic. However, very little is known about this important topic. In the present study, we investigated the effects of hyperthermia on the protect...

journal_title：Neurochemical research

authors： Du F,Qian ZM,Zhu L,Wu XM,Yung WH,Ke Y

更新日期：2011-02-01 00:00:00

abstract：:Diurnal changes in Chordc1 mRNA were recently described in mouse hypothalamus. This report shows that Chordc1 mRNA changes rhythmically throughout the entire adult brain with highest expression levels occurring around the dark-light transition. The rhythmic cycling pattern of Chordc1 was retained under various light-d...

journal_title：Neurochemical research

authors： Gerstner JR,Landry CF

更新日期：2007-02-01 00:00:00

abstract：:DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conforma...

journal_title：Neurochemical research

authors： Ivanov TR,Brown IR

更新日期：1989-02-01 00:00:00

abstract：:Neuropeptides are derived from large and inactive proteins which require endoproteolytic processing for the biosynthesis of the bioactive peptides. The maturation of pro-neuropeptide to neuropeptide is believed to be performed by ortholog pro-protein convertase EGL-3 in Caenorhabditis elegans (C. elegans). Furthermore...

journal_title：Neurochemical research

authors： Salem JB,Nkambeu B,Arvanitis DN,Beaudry F

更新日期：2018-11-01 00:00:00

abstract：:Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...

journal_title：Neurochemical research

authors： Lie MEK,Kickinger S,Skovgaard-Petersen J,Ecker GF,Clausen RP,Schousboe A,White HS,Wellendorph P

更新日期：2020-07-01 00:00:00