Abstract：
:Quantitative measurements were made of choline acetyltransferase (CAT) activity, acetylcholinesterase (AChE) activity and cholinergic muscarinic receptor binding ([3H]QNB) in eight areas of a cross-section of the rat medulla oblongata. A fourth cholinergic parameter, high-affinity choline uptake, was measured in three groups of these areas. CAT, AChE and [3H]QNB binding were found to be highest in the hypoglossal nucleus and the dorsal motor nucleus of the vagus; the lowest value was in the area which contains the inferior olive and the corticospinal tract. The distribution of AChE and CAT activities varied approximately 7- to 10-fold among the eight regions examined, whereas that of the muscarinic receptor varied only about 4-fold. The Na+-dependent high-affinity choline uptake varied approximately 20-fold from the region with the lowest activity (inferior olivary nucleus and corticospinal tract) to that with the highest activity (tissue areas containing the dorsal motor nucleus, hypoglossal nucleus of the solitary tract and nucleus cuneatus). The four cholinergic parameters are statistically correlated throughout all the areas of the medulla which were studied.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Simon JR,Oderfeld-Nowak B,Felten DL,Aprison MHdoi
10.1007/BF00964389subject
Has Abstractpub_date
1981-05-01 00:00:00pages
497-505issue
5eissn
0364-3190issn
1573-6903journal_volume
6pub_type
杂志文章abstract：:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964440
更新日期：1979-10-01 00:00:00
abstract：:Postnatal developmental patterns of activity for acid and alkaline deoxyribonuclease (DNase) were determined in the cerebellum of the androgenized female rat. Littermates were injected s.c. with either 1.25 mg testosterone propionate (TP) or vehicle 48 hours after birth. The enzymes and DNA content were measured in th...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964659
更新日期：1985-04-01 00:00:00
abstract：:6-Hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS) that are associated with various neurodegenerative diseases such as Parkinson's disease. 3,3',4',7-Tetrahydroxyflavone (fisetin), a plant flavonoid has a variety of physiological effects such as antioxidant activity. In this study, we i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2445-z
更新日期：2018-02-01 00:00:00
abstract：:The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately 50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level during a 1-year period of treatment as compared to placebo. Recent studies show that in a certain percentage (approximately 20%) of pa...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1022869222652
更新日期：2003-04-01 00:00:00
abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2486-y
更新日期：2018-04-01 00:00:00
abstract：:Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we int...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03138-4
更新日期：2020-12-01 00:00:00
abstract：:Treatment for epilepsy, particularly temporal lobe epilepsy, is challenging. Baicalein has multiple effects, including anti-inflammatory action. However, little is known about its efficacy in treatment of epilepsy. In this study, we established a pilocarpine-induced rat model and used it for assessment of baicalein ef...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-020-03150-8
更新日期：2020-12-01 00:00:00
abstract：:The calcium-activated phosphodiesteratic hydrolysis of 32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965878
更新日期：1985-08-01 00:00:00
abstract：:The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applicat...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-9966-z
更新日期：2009-11-01 00:00:00
abstract：:Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in isoflurane-induced neuronal damage. Lidocaine has been demonstrated to attenuate the impairment of cognition in aged rats induced by isoflurane in our previous study. In this study, we hypothesized that lidocaine could attenuate...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02799-0
更新日期：2019-07-01 00:00:00
abstract：:Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about...
journal_title：Neurochemical research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00975048
更新日期：1993-12-01 00:00:00
abstract：:Neuronal perikarya were isolated, using bulk preparative procedures, from bovine brains. Synaptosomes, neuronal perikarya, and brain homogenates had similar ganglioside patterns, with the synaptosomes containing at least four times more total ganglioside per mg protein than the neuronal perikarya and twice that of the...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966108
更新日期：1976-04-01 00:00:00
abstract：:With the aid of histochemical and electrophoretic techniques activities for esterase and esterprotease were investigated in the digastric and masseter muscles from normal and dystrophic mice. The substrates used were alpha-naphthyl acetate and N-acetyl-L-alanine alpha-naphthyl ester. According to the microscopic obser...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971312
更新日期：1989-03-01 00:00:00
abstract：:Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1729-4
更新日期：2015-10-01 00:00:00
abstract：:Blood-brain barrier formed by brain capillary endothelial cells, being in contact with astrocytes endfeet and pericytes, separates extracellular fluid from plasma. Supply of necessary nutrients and removal of certain metabolites takes place due to the activity of transporting proteins from ABC (ATP binding cassette) a...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-016-2030-x
更新日期：2017-03-01 00:00:00
abstract：:The neurotrophins brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are both expressed in developing cerebellum in addition to their tyrosine kinase receptors. TrkB and TrkC. In contrast to BDNF.NT-3 has only a negligible or a transient survival activity on cultured cerebellar granule neurons. The gra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532309
更新日期：1996-07-01 00:00:00
abstract：:Role of the orexinergic system in pain modulation is well studied and involvement of the spinal orexin-1 receptors is well documented. In this study, we examined role of the spinal orexin-2 receptors in modulation of inflammatory pain in rat. Fifty-one adult male Wistar rats were implanted unilaterally with a guide ca...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02749-w
更新日期：2019-05-01 00:00:00
abstract：:The cellular uptake of the GABA-transaminase inhibitors gamma-vinyl GABA (GVG) and gamma-acetylenic GABA (GAG) was studied in cultured neurons and astrocytes. By the use of the individual enantiomers R- and S-GVG and R- and S-GAG it could be shown that in both cell types only the S-enantiomers could be actively transp...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965769
更新日期：1986-11-01 00:00:00
abstract：:The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines. VRI protein was de...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000018839.59457.5c
更新日期：2004-04-01 00:00:00
abstract：:Glutamate and its receptors are expressed very early during development and may play important roles in neurogenesis, synapse formation and brain wiring. The levels of glutamate and activity of its receptors can be influenced by exogenous factors, leading to neurodevelopmental disorders. To investigate the role of NMD...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9213-9
更新日期：2007-02-01 00:00:00
abstract：:BCL-2-associated athanogene-1(BAG-1) is a multifunctional and anti-apoptotic protein that was first identified as a binding partner of BCL-2. But the effects and mechanisms for BAG-1 against hypoxic damage is unclear up to now. Whether BAG-1 could protect the human brain against hypoxic damage through up-regulating 70...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2304-y
更新日期：2017-10-01 00:00:00
abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1078-0
更新日期：2013-08-01 00:00:00
abstract：:It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000035800.65411.3e
更新日期：2004-09-01 00:00:00
abstract：:The immediate and long-term effects of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) on rat striatal serotonergic neurons were examined after its intracerebroventricular administration using in vivo voltammetry. Extracellular concentration of 5-hydroxyindoles increased immediately following i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022460216822
更新日期：1998-01-01 00:00:00
abstract：:The effect of isoproterenol, norepinephrine, dopamine, and serotonin on the accumulation of adenosine 3',5'-monophosphate (cAMP) was studied in homogeneous neuronal cultures from 8-day chick embryo hemispheres. Among the catecholamines, isoproterenol had a more pronounced effect on the accumulation of cAMP. Norepineph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966167
更新日期：1980-10-01 00:00:00
abstract：:Recent studies have demonstrated a scrutinized association of diabetes mellitus with depressive symptoms and major depression. Glycogen synthase kinase-3 (GSK-3) is a protein kinase enzyme constitutively active in non-stimulated cells and in multiple signalings. Independent lines of research provide a converging evide...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1670-6
更新日期：2015-09-01 00:00:00
abstract：:Lewy bodies and Lewy neurites in the brain constitute the main histopathological features of Parkinson's disease (PD) and dementia with Lewy bodies. They comprise amyloid-like fibrils composed of α-synuclein (αS), a small protein (~14 kDa). Because the aggregation of αS in the brain has been implicated as a critical s...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-017-2382-x
更新日期：2017-12-01 00:00:00
abstract：:The study examined (a) whether there is sex difference in spinal cord and plasma oxidative stress profiles in Dark Agouti rats immunised for experimental autoimmune encephalomyelitis (EAE), the principal experimental model of multiple sclerosis, and (b) whether there is correlation between the oxidative stress in spin...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2094-7
更新日期：2017-02-01 00:00:00
abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1975-0
更新日期：2016-10-01 00:00:00
abstract：:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966062
更新日期：1982-11-01 00:00:00
