Abstract:
:The vanilloid receptor 1(VR1) is a nonselective cation channel that is activated by pungent vanilloid compound, extracellular protons, or noxious heat. mRNA of VR1 and vanilloid receptor 1-like receptor (VRL1) were expressed in PC12 cells, and only VRI mRNA was detected in glioma and A10 cell lines. VRI protein was demonstrated in PC12 cells by immunocytochemistry and Western blotting. Capsaicin (CPS), the VRI receptor agonist, led to an increase in intracellular calcium ion, and this effect was blocked by pretreatment with VR1 receptor antagonist capsazepin (CPZ). Treatment of PC12 cells with low concentration of CPS (5-50 microM) increased reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS) was expressed after CPS treatment for 24 h. These CPS-induced changes are inhibited by pretreatment of CPZ. These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Qiao S,Li W,Tsubouchi R,Murakami K,Yoshino Mdoi
10.1023/b:nere.0000018839.59457.5ckeywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
687-93issue
4eissn
0364-3190issn
1573-6903journal_volume
29pub_type
杂志文章abstract::Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...
journal_title:Neurochemical research
pub_type: 杂志文章
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journal_title:Neurochemical research
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更新日期:2007-09-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00995388
更新日期:1995-10-01 00:00:00
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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更新日期:1979-06-01 00:00:00
abstract::SENP3 (SUMO-specific proteases 3), a member of the small ubiquitin-like modifier specific protease family, was identified as a molecule that deconjugates SUMOylation of modified protein substrates and functions as an isopeptidase by disrupting SUMO homeostasis to facilitate cancer development and progression. However,...
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pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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更新日期:2005-12-01 00:00:00
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更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF01000040
更新日期:1989-04-01 00:00:00
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更新日期:1989-08-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022403224901
更新日期:1997-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11064-017-2366-x
更新日期:2017-11-01 00:00:00
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doi:10.1007/s11064-010-0177-4
更新日期:2010-08-01 00:00:00
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更新日期:2019-04-01 00:00:00
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doi:10.1007/BF00965738
更新日期:1990-10-01 00:00:00
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更新日期:2017-11-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00