Danhong injection attenuates ischemia/reperfusion-induced brain damage which is associating with Nrf2 levels in vivo and in vitro.

abstract：:In order to obtain further evidence of putative neurotransmitters in primary sensory neurons and interneurons in the dorsal spinal cord, we have studied the effects of unilateral section of dorsal roots and unilateral occlusion of the dorsal spinal artery on cholinergic enzyme activity and on selected amino acid level...

journal_title：Neurochemical research

authors： Fujita K,Nagata Y

更新日期：1989-05-01 00:00:00

abstract：:Hemin is a breakdown product of the blood protein, hemoglobin and is responsible for much of the secondary damage caused following a hemorrhagic stroke. Hemin is toxic to cultured astrocytes and it is thought that this toxicity is due to iron that is liberated when hemin is degraded. However, free iron applied to astr...

journal_title：Neurochemical research

authors： Owen JE,Bishop GM,Robinson SR

更新日期：2016-02-01 00:00:00

abstract：:Cerebral deposition of amyloid β-peptide (Aβ), a fundamental feature of Alzheimer's disease (AD), damages the neurocytes and impairs the cognition functions and associative learning memory of AD patients. A series of novel 2-arylethenylquinoline derivatives were synthesized and evaluated in our previous study, which i...

journal_title：Neurochemical research

authors： He Q,Huang G,Chen Y,Wang X,Huang Z,Chen Z

更新日期：2017-11-01 00:00:00

abstract：:Cerebral blood flow (CBF) and cerebellar blood flow (CeBF) were measured and correlated with brain lactate, pyruvate and adenosine triphosphate concentrations from groups representing 3-week old suckling (n = 10), 18-22-week old adult (n = 9) and 70-week old aged (n = 7) Sprague-Dawley rats before and during bilateral...

journal_title：Neurochemical research

authors： He Z,Ibayashi S,Sugimori H,Fujii K,Sadoshima S,Fujishima M

更新日期：1997-01-01 00:00:00

abstract：:A role for protein phosphorylation in the process of neurite outgrowth has been inferred from many studies of the effects of protein kinase inhibitors and activators on cultured neurotumor cells and primary neuronal cells from developing brain or ganglia. Here we re-examine this issue, using a culture system derived f...

journal_title：Neurochemical research

authors： Heacock AM,Agranoff BW

更新日期：1997-10-01 00:00:00

abstract：:Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...

journal_title：Neurochemical research

authors： Rochelle JM,Grossfeld RM,Bunting DL,Tytell M,Dwyer BE,Xue ZY

更新日期：1991-05-01 00:00:00

abstract：:GABAergic and cholinergic synaptosome populations were isolated by immunomagnetophoresis. Analysis of 8 amino acids showed that the GABAergic population was enriched in GABA (3 fold). The cholinergic population was enriched in citrulline (5 fold). CCK was found in both populations, but was enriched in the GABAergic. N...

journal_title：Neurochemical research

authors： Hughes PD,Foley P,Bradford HF,Ghatei M,Khandanian N,Bloom SR,Wu JY

更新日期：1993-04-01 00:00:00

abstract：:Rats fed a vitamin E-deficient diet for 7--8 weeks postweaning showed no change in brain weight or the activity in brain of various enzymes involved in neurotransmitter synthesis and metabolism. Body and muscle weights were markedly reduced. Muscle choline acetyltransferase and acetylcholinesterase activities were sig...

journal_title：Neurochemical research

authors： Sung SC,Sandberg PR,McGeer EG

更新日期：1978-12-01 00:00:00

abstract：:It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...

journal_title：Neurochemical research

authors： Potapenko E,Kostyuk E,Voitenko N,Kostyuk P

更新日期：2004-09-01 00:00:00

abstract：:Propofol and ketamine may provide certain degree of neuroprotection, but the underlying mechanism remains unclear to date. The cAMP response element-binding protein (CREB) was proposed that its phosphorylation at Ser133 (P-CREB) constituted a convergence point involved in neuroprotection. The purpose of this study was...

journal_title：Neurochemical research

authors： Shu L,Li T,Han S,Ji F,Pan C,Zhang B,Li J

更新日期：2012-01-01 00:00:00

abstract：:This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice ...

journal_title：Neurochemical research

authors： Huang XF,Yu Y,Li Y,Tim S,Deng C,Wang Q

更新日期：2008-09-01 00:00:00

abstract：:Brief limb ischemia was reported to protect neurons against injury induced by subsequent cerebral ischemia-reperfusion, and this phenomenon is known as limb ischemic preconditioning (LIP). To explore the role of nitric oxide (NO) in neuroprotection of LIP in rats, we observed changes in the content of nitric oxide (NO...

journal_title：Neurochemical research

authors： Zhao HG,Sun XC,Xian XH,Li WB,Zhang M,Li QJ

更新日期：2007-11-01 00:00:00

abstract：:Several previous studies utilizing selective pharmacological antagonists have demonstrated that type 5 metabotropic glutamate receptors (mGluR5) are potential therapeutic targets for the treatment of numerous disorders of the central nervous system, but the role of mGluR5 activation in traumatic brain injury (TBI) is ...

journal_title：Neurochemical research

authors： Chen T,Cao L,Dong W,Luo P,Liu W,Qu Y,Fei Z

更新日期：2012-05-01 00:00:00

abstract：:Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure ...

journal_title：Neurochemical research

authors： Berríos VO,Boukli NM,Rodriguez JW,Negraes PD,Schwindt TT,Trujillo CA,Oliveira SL,Cubano LA,Ferchmin PA,Eterović VA,Ulrich H,Martins AH

更新日期：2015-10-01 00:00:00

abstract：:Cathepsin B (EC 3.4.22.1) was purified 746-fold with a 21% recovery from bovine brain by autolysis, fractional precipitation with acetone, carboxy-methyl-Sephadex chromatography, affinity chromatography on a cystamine containing column and gel filtration chromatography. The purified cathepsin B eluted on gel filtratio...

journal_title：Neurochemical research

authors： Bradley JD,Whitaker JN

更新日期：1986-06-01 00:00:00

abstract：:Primary malignant brain cancer, one of the most deadly diseases, has a high rate of recurrence after treatment. Studies in the past several years have led to the hypothesis that the root of the recurrence may be brain tumor stem cells (BTSCs), stem-like subpopulation of cells that are responsible for propagating the t...

journal_title：Neurochemical research

authors： Xie Z

更新日期：2009-12-01 00:00:00

abstract：:An analytical method for the determination of saturated very long chain (VLC) fatty acids in the serum has been devised. Free fatty acids obtained after hydrolysis of total lipid extracts were converted into p-bromophenacyl esters. The derivatives were purified in two sequential steps by clean-up on C18 reversed-phase...

journal_title：Neurochemical research

authors： Alberghina M,Fiumara A,Pavone L,Giuffrida AM

更新日期：1984-12-01 00:00:00

abstract：:Evidence that brain glutamatergic activity is pathologically elevated in bipolar disorder suggests that mood stabilizers are therapeutic in the disease in part by downregulating glutamatergic activity. Such activity can involve the second messenger, arachidonic acid (AA, 20:4n - 6). We tested this hypothesis with rega...

journal_title：Neurochemical research

authors： Basselin M,Chang L,Chen M,Bell JM,Rapoport SI

更新日期：2008-11-01 00:00:00

abstract：:Apoptotic cell death pathways have been implicated in acute brain injuries, including cerebral ischemia, brain trauma, and spinal cord injury, and in chronic neurodegenerative diseases. Experimental ischemia and reperfusion models, such as transient focal/global ischemia in rodents, have been thoroughly studied and su...

journal_title：Neurochemical research

authors： Chan PH

更新日期：2004-11-01 00:00:00

abstract：:During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...

journal_title：Neurochemical research

authors： Vardjan N,Zorec R

更新日期：2015-12-01 00:00:00

abstract：:5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GC-MS of the ditrifluoromethylbenzoyl...

journal_title：Neurochemical research

authors： Andrew R,Watson DG,Best SA,Midgley JM,Wenlong H,Petty RK

更新日期：1993-11-01 00:00:00

abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...

journal_title：Neurochemical research

authors： Brockerhoff H,Wisniewski HM,Lipton LC,Deshmukh DS

更新日期：1980-06-01 00:00:00

abstract：:Brain regional 5-HT (5-hydroxytryptamine) and 5-HIAA (5-hydroxyindole-3-acetic acid) concentrations in male LE rats at three times were measured by a fluorescence method, to evaluate effects of intracranial surgery and administration of melatonin on the changes in these compounds during the first part of the dark phas...

journal_title：Neurochemical research

authors： Quay WB

更新日期：1989-10-01 00:00:00

abstract：:We previously reported that vanilloid receptor type 1 (VR1, or TRPV1) was up-regulated in dorsal root ganglion (DRG) and the spinal dorsal horn after chronic inflammatory pain produced by complete Freund's adjuvant (CFA) injection into the plantar of rat hind paw. In the present study, we found that subcutaneous or in...

journal_title：Neurochemical research

authors： Luo H,Xu IS,Chen Y,Yang F,Yu L,Li GX,Liu FY,Xing GG,Shi YS,Li T,Han JS,Wan Y

更新日期：2008-10-01 00:00:00

abstract：:Excitatory and inhibitory neurotransmission in the central nervous system can be modulated by neurosteroids. We previously found that in rat hippocampal slices allopregnanolone (3α-hydroxy-5α-pregnan-20-one), a positive GABA(A) receptor modulator, suppresses the epileptic discharges induced by 4-aminopyridine (4-AP), ...

journal_title：Neurochemical research

authors： Salazar P,Tapia R

更新日期：2012-03-01 00:00:00

abstract：:A case-control study was undertaken to investigate the status of platelet monoamine oxidase-B (MAO-B) activity in Indian cases of idiopathic Parkinson's disease. A significant increase in the activity of platelet MAO-B was observed in Parkinson's cases (n = 26) as compared to controls (n = 26). No significant change i...

journal_title：Neurochemical research

authors： Husain M,Shukla R,Dikshit M,Maheshwari PK,Nag D,Srimal RC,Seth PK,Khanna VK

更新日期：2009-08-01 00:00:00

abstract：:The modulation of intracellular GABA activated 36Cl- in-->out permeation across single Deiters' neuron membranes has been studied in a microchamber system. Addition of Mg2+/ATP on the membrane cytoplasmic side reduces strongly the GABA effect as does ATP alone. However, the greatest inhibition of the GABA effect is gi...

journal_title：Neurochemical research

authors： Rapallino MV,Cupello A,Hydén H

更新日期：1999-08-01 00:00:00

abstract：:Exploring the neurochemical continuum between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) with respect to monoamines and kynurenines in cerebrospinal fluid (CSF) and serum, may be useful to identify possible new research/therapeutic targets. Hence, we analysed monoamines and kynurenines in CS...

journal_title：Neurochemical research

authors： Janssens J,Vermeiren Y,van Faassen M,van der Ley C,Kema IP,De Deyn PP

更新日期：2020-05-01 00:00:00

abstract：:When excised goldfish spinal cord is kept in physiological saline at room temperature, the myelin multilayers swell. As studied by X-ray diffraction, the original repeating distance of 150 A (AS myelin) swells to 177 A (AL myelin); no intermediate distances are seen. At least 70% of the myelin can undergo this gradual...

journal_title：Neurochemical research

authors： Blaurock AE,Yale JL,Roots BI

更新日期：1986-08-01 00:00:00

abstract：:The current study investigated the neuroprotective activity of idebenone against pilocarpine-induced seizures and hippocampal injury in rats. Idebenone is a ubiquinone analog with antioxidant, and ATP replenishment effects. It is well tolerated and has low toxicity. Previous studies reported the protective effects of ...

journal_title：Neurochemical research

authors： Ahmed MA

更新日期：2014-02-01 00:00:00