Abstract：
:5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GC-MS of the ditrifluoromethylbenzoyl-trimethylsilyl (DTFMB-TMS) derivatives of the compounds. The concentrations of 5- and 6-hydroxydopamine in the urine of DOPA treated Parkinson's patients were significantly higher than the concentrations from patients not treated and from normal controls. Urinary dopamine levels were greatly elevated in DOPA treated Parkinson's patients while p-tyramine levels were suppressed. No marked differences were seen between the three groups in terms of the urinary concentrations of any of the other amines measured.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Andrew R,Watson DG,Best SA,Midgley JM,Wenlong H,Petty RKdoi
10.1007/BF00978370subject
Has Abstractpub_date
1993-11-01 00:00:00pages
1175-7issue
11eissn
0364-3190issn
1573-6903journal_volume
18pub_type
杂志文章abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...
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pub_type： 杂志文章
doi：10.1007/BF00966224
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