Abstract：
:We have investigated gene expression changes produced by acute and chronic daily treatment with a prototypical antidepressant, imipramine, using DNA microarrays. The analysis of similarities in gene expression patterns among functionally related genes revealed four expression profile cluster areas that showed a highly significant overrepresentation of several functional classes. Genes encoding for proteins involved in cAMP metabolism, postsynaptic membrane proteins, and proto-oncogenes were overrepresented in different cluster areas. Furthermore, we found that serine proteases as a group were similarly regulated by chronic antidepressant treatment. Our data suggest that cAMP metabolism, synaptic function, and protein processing by serine proteases may be important targets of antidepressant treatment and potential objects for antidepressant drug development.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Knuuttila JE,Törönen P,Castrén Edoi
10.1023/b:nere.0000023610.89631.d6keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
1235-44issue
6eissn
0364-3190issn
1573-6903journal_volume
29pub_type
杂志文章abstract：:A study of separate and combined actions of cobra venom (CV) and a new hypothalamic proline-rich polypeptide (PRP) isolated from magnocellular cells (NPV and NSO) on intoxication- and trauma-induced neuronal injury (during 3-4 weeks after hemisection with and without PRP treatment) was carried out. The registration of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1012353005489
更新日期：2001-09-01 00:00:00
abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007696112956
更新日期：2000-10-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-016-1829-9
更新日期：2016-06-01 00:00:00
abstract：:Glutamate is the primary excitatory neurotransmitter in brain. By stimulating neuronal activity, glutamate increases cellular energy utilization, enhances ATP hydrolysis and promotes the formation of adenosine. Adenosine has receptor-mediated effects that reduce or oppose the excitatory effects of glutamate. As a poss...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1014955111742
更新日期：2002-04-01 00:00:00
abstract：:The inflammatory response mediated by microglia in the central nervous system is closely related to epilepsy. Notch signaling plays an important role in the microglial activation during hypoxia. This study aimed to investigate whether Notch signaling is involved in microglial activation and subsequent inflammation-rel...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-018-2544-5
更新日期：2018-06-01 00:00:00
abstract：:The influence of phosphatidylserine (PS) on the isoniazid-induced convulsions has been studied in mice. Sonicated dispersions of this phospholipid given intravenously do not show anticonvulsant activity but they do so when gamma-aminobutyric acid (GABA) is simultaneously injected. GABA alone is inactive. The synergism...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964802
更新日期：1984-08-01 00:00:00
abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022482520358
更新日期：1997-03-01 00:00:00
abstract：:The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532298
更新日期：1996-07-01 00:00:00
abstract：:Convulsant doses of penicillin and elevated ambient pressure of 41 bar enhance the excitability of neurons. Their effects have been studied in neostriatal tissue with methods allowing differentiation between transmitter and metabolic glutamate pools. Levels of glutamate (Glu), glutamine (Gln), aspartate (Asp); gamma-a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965621
更新日期：1989-11-01 00:00:00
abstract：:During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-015-1545-x
更新日期：2015-12-01 00:00:00
abstract：:Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963809
更新日期：1979-06-01 00:00:00
abstract：:Tyrosinemia type II, also known as Richner-Hanhart syndrome, is an autosomal recessive inborn error of metabolism caused by a deficiency of hepatic cytosolic tyrosine aminotransferase, and is associated with neurologic and development difficulties in numerous patients. Considering that the mechanisms underlying the ne...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-1180-3
更新日期：2013-12-01 00:00:00
abstract：:We evaluated oxidative stress associated with a model of experimental epilepsy. Male Wistar rats were injected i.p. with 150 mg/kg convulsant 3-mercaptopropionic acid and decapitated in two stages: during seizures or in the post-seizure period. Spontaneous chemiluminescence, levels of thiobarbituric acid reactive subs...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF03177490
更新日期：1998-12-01 00:00:00
abstract：:Some crustacean axons remain functional for months after injury. This unusual property may require stress proteins synthesized by those neurons or provided to them by glial cells. To begin to explore this hypothesis, we examined the conditions that stimulated stress protein synthesis by crayfish CNS tissue in vitro. I...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00974871
更新日期：1991-05-01 00:00:00
abstract：:The major breakthrough discovery of enkephalins as endogenous opiates led our attempts to determine their inactivation mechanisms. Because the NH2-terminal tyrosine is absolutely necessary for the neuropeptides to exert analgesic effects, and aminopeptidase activities are extraordinarily high in the brain, a specific ...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-007-9356-3
更新日期：2007-12-01 00:00:00
abstract：:In order to obtain further evidence of putative neurotransmitters in primary sensory neurons and interneurons in the dorsal spinal cord, we have studied the effects of unilateral section of dorsal roots and unilateral occlusion of the dorsal spinal artery on cholinergic enzyme activity and on selected amino acid level...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964851
更新日期：1989-05-01 00:00:00
abstract：:Endoplasmic reticulum (ER) and mitochondria are intracellular organelles and their interactions are directly involved in different processes such as Ca(2+) signaling in cell survival and death mechanisms. Bcl-2 is an anti-apoptotic protein intrinsically related to ER and mitochondria, modulating Ca(2+) content in thes...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-011-0600-5
更新日期：2012-02-01 00:00:00
abstract：:In the experimental setting, taurine is known to be released from swollen cells to reestablish their normal volume. However, its clinical relevance has not been fully understood. This study was undertaken to reveal changes in cerebrospinal fluid (CSF) amino acids concentration in patients with severe traumatic brain i...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-004-9693-4
更新日期：2005-01-01 00:00:00
abstract：:Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in re...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965332
更新日期：1986-05-01 00:00:00
abstract：:The effect of isoproterenol, norepinephrine, dopamine, and serotonin on the accumulation of adenosine 3',5'-monophosphate (cAMP) was studied in homogeneous neuronal cultures from 8-day chick embryo hemispheres. Among the catecholamines, isoproterenol had a more pronounced effect on the accumulation of cAMP. Norepineph...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966167
更新日期：1980-10-01 00:00:00
abstract：:Sandhoff disease is an incurable neurodegenerative disorder caused by mutations in the lysosomal hydrolase β-hexosaminidase. Deficiency in this enzyme leads to excessive accumulation of ganglioside GM2 and its asialo derivative, GA2, in brain and visceral tissues. Small molecule inhibitors of ceramide-specific glucosy...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-013-0992-5
更新日期：2013-04-01 00:00:00
abstract：:Metabolism of triacylglycerol (TAG) in developing brain has been examined. TAG is a relatively minor fraction of brain lipid in both suckling and adult rats and cannot be accounted for as entrapped blood. When glycerol tri[1-14C]oleate and [2-3H]glycerol trioleate were simultaneously injected intracerebrally into suck...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00966679
更新日期：1981-11-01 00:00:00
abstract：:Single prolonged stress (SPS) rats is a rodent model of post traumatic stress disorder (PTSD). Abnormal hippocampal morphology and function were found in the PTSD patients. Our previous study has shown that SPS induce loss of hippocampal neurons. But the effects of SPS on glial cells in the hippocampus have not been e...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1549-6
更新日期：2015-05-01 00:00:00
abstract：:Abnormally high levels of iron are observed in the brain of patients suffering from neurodegenerative disorders. The mechanisms involved in iron accumulation in neurodegenerative disorders remain poorly understood. In the present study we investigated the effects of aging and neonatal iron overload on the mRNA express...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-009-0100-z
更新日期：2010-04-01 00:00:00
abstract：:The insoluble fraction of ox-brain, which had previously been shown to have a non-linear affinity for Na+ and K+, was prepared. Acetylcholine (1 x 10(-8) mol/l and 1 x 10(-7) mol/l) reduced the affinity of the fraction for Na+ and K+ to zero, while at 1 x 10(-6) mol/l, the affinity for the cations was almost as high a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969636
更新日期：1989-02-01 00:00:00
abstract：:Ochratoxin A (OA) is a mycotoxin produced by several storage fungi, such as Aspergillus ochraceus and several Penicillium species. OA (3 mg/kg) was given intraperitoneally to pregnant mice on day 11 of gestation (day 1 = day of insemination), and neurochemical changes in brains of their offspring were examined at feta...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971631
更新日期：1988-12-01 00:00:00
abstract：:Staurosporine was found to bring about complete growth inhibition of human glioma cell lines. U87 MG cells were arrested in S phase while U373 MG cells in G2/M phase on staurosporine treatment. Consistent with this observation, no change in G1 phase regulators viz., Cyclin D1, D3 and CDK4 was seen on staurosporine tre...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9068-0
更新日期：2006-05-01 00:00:00
abstract：:The specific precursors for neurotransmitter pools of glutamate giving rise to GABA in GABAergic neurons and nerve endings have not been clearly established. Glutamate is the immediate precursor for the production of GABA and it is suggested that ornithine (from arginine) might be serving as one of the precursors of g...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964593
更新日期：1984-11-01 00:00:00
abstract：:The steady-state mRNA levels of NGF, BDNF and NT-3, and the mRNA levels of their receptors p75NGFR, trk, trkB, and trkC were examined in various human peripheral neuropathies, to determine the correlation with myelinated fiber pathology and T cell and macrophage invasions in the diseased nerves. Steady state levels of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022434209787
更新日期：1998-06-01 00:00:00
abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965726
更新日期：1983-03-01 00:00:00
