Abstract:
:The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered intraventricularly one day before and immediately following occlusion. Rats were sacrificed at 1, 4 and 7 days after occlusion. NT-4/5 treatment reduced infarction volume by 34% when compared to control rats 1 day after occlusion. Infarction volume was unaltered by treatment 4 to 7 days after occlusion. Middle cerebral artery occlusion led to a significant reduction in levels of mRNAs coding for catalytic and truncated TrkB receptors. This expression was unaffected by NT-4/5 treatment.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Chan KM,Lam DT,Pong K,Widmer HR,Hefti Fdoi
10.1007/BF02532298subject
Has Abstractpub_date
1996-07-01 00:00:00pages
763-7issue
7eissn
0364-3190issn
1573-6903journal_volume
21pub_type
杂志文章abstract::The presence and specificity of insulin receptors was investigated in culture cells obtained from 15-16 days old embryonic mouse cerebra. Developmental studies suggested that the maximum insulin binding occurred at about 11 days in vitro (DIV). Scatchard analysis of binding data revealed two types of binding sites. On...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01268877
更新日期:1988-05-01 00:00:00
abstract::During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1545-x
更新日期:2015-12-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is an adult-onset, irreversible neurodegenerative disease that leads to progressive paralysis and inevitable death 3-5 years after diagnosis. The mechanisms underlying this process remain unknown, but new evidence indicates that accumulating levels of D-serine result from the downre...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-2131-6
更新日期:2017-04-01 00:00:00
abstract::Hypoxia-induced oxidative stress is one of the major hallmark reasons underlying brain dysfunction. In the present manuscript, we have used CoCl2-induced hypoxic mice to investigate alterations in the activities of chief antioxidative stress enzymes- superoxide dismutase (SOD) and catalase (CAT) and expression of thei...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1388-x
更新日期:2014-09-01 00:00:00
abstract::In the unrestrained rat, the hyperphagic-like ingestion of food evoked by the sustained elevation of neuropeptide-Y (NPY) in the hypothalamus was correlated with the release and turnover of monoaminergic transmitters in this structure. A single guide tube was implanted stereotaxically in the perifornical region of the...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00967290
更新日期:1992-11-01 00:00:00
abstract::The wobbler mouse suffers an autosomal recessive mutation producing severe neurodegeneration and astrogliosis in spinal cord. It has been considered a model for amyotrophic lateral sclerosis. We have studied in these animals the expression of two proteins, the growth-associated protein (GAP-43) and the NADPH-diaphoras...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020918310281
更新日期:1999-01-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disease, with genetics and environment contributing to the disease onset. The limited pathological cognize of the disease restrained the approaches to improve the clinical treatment. Recently, studies showed that endoplasmic reticulum (ER) stress played an important role...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1922-0
更新日期:2016-08-01 00:00:00
abstract::Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1840-1
更新日期:2016-06-01 00:00:00
abstract::Specific [3H]MK801 binding to rat brain NMDA receptors after the administration of the convulsant drug 3-mercaptopropionic acid (MP) and the adenosine analogue cyclopentyladenosine (CPA) was studied by means of a quantitative autoradiographic method. MP administration (150 mg/kg, i.p.) caused significant decreases in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020708603495
更新日期:1998-10-01 00:00:00
abstract::The incidence of acute and chronic spinal cord injury (SCI) in the United States is more than 10,000 per year, resulting in 720 cases per million persons enduring permanent disability each year. The economic impact of SCI is estimated to be more than 4 billion dollars annually. Preclinical studies, case reports, and s...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-013-0991-6
更新日期:2013-05-01 00:00:00
abstract::The monoclonal antibody 14E immunocytochemically stains the nuclear membrane of oligodendrocytes but not myelin in tissue sections of adult normal human white matter. The nuclear membranes of Schwann cells in human peripheral nerve and cerebellar Bergmann glia were also visualized with this antibody. In actively demye...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00993270
更新日期:1992-09-01 00:00:00
abstract::The effects of 100microg melatonin injection at postnatal day 5 (PD 5) on the development of the central serotonergic systems in male and female rats were investigated. The contents of serotonin (5-HT) and 5-hydroxy-3-indolacetic acid (5-HIAA) were measured in several extrahypothalamic regions at 3, 10 and 42 weeks of...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1007517524179
更新日期:2000-06-01 00:00:00
abstract::The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0809-y
更新日期:2012-09-01 00:00:00
abstract::Oligodendrocytes (OL) are the only myelinating cells of the central nervous system thus interferences, either environmental or genetic, with their maturation or function have devastating consequences. Albeit so far neglected, one of the less appreciated, nevertheless possible, regulators of OL maturation and function ...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-019-02778-5
更新日期:2020-03-01 00:00:00
abstract::One hour incubation of rat cortical slices in a medium without oxygen and glucose (oxygen-glucose deprivation, OGD) increased S100B release to 6.53 ± 0.3 ng/ml/mg protein from its control value of 3.61 ± 0.2 ng/ml/mg protein. When these slices were then transferred to a medium containing oxygen and glucose (reoxygenat...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1301-7
更新日期:2014-07-01 00:00:00
abstract::Previous studies have shown that chronic administration of SR-3 (a 1:4 mixture of alpha-linolenic and linoleic acid) affects spatial learning, thermoregulation, pain threshold and protection from seizures. The mode of action is unknown. One possible explanation is that the preparation induces changes in the fatty acid...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022430620205
更新日期:1998-05-01 00:00:00
abstract::We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1185-y
更新日期:2013-12-01 00:00:00
abstract::Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain, many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, man...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0280-6
更新日期:2011-01-01 00:00:00
abstract::Deprenyl has been discovered by Knoll and co-workers. The R-enantiomer of deprenyl (selegiline) is a selective and irreversible inhibitor of the B-isoform of monoamine oxidase (MAO-B) enzyme. Due to its dopamine potentiating and possible neuroprotective properties it has an established role in the treatment of parkins...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0238-8
更新日期:2010-12-01 00:00:00
abstract::Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress....
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1360-9
更新日期:2014-09-01 00:00:00
abstract::Traumatic brain injury (TBI) initiates a series of neurochemical and signaling changes that could eventually lead to neuronal apoptosis. Recent studies indicated that mature neurons cell cycle re-enter played a crucial role in neuronal apoptosis. In this study, we identified that the chaperonin containing TCP-1, subun...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1683-1
更新日期:2015-09-01 00:00:00
abstract::The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the extern...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-005-7412-4
更新日期:2005-09-01 00:00:00
abstract::The effect of phenobarbital (100 mg/kg i.p.) and 6-aminonicotinamide (6AN) (35 mg/kg i.p.) on enzyme activities related to energy transduction was investigated on the homogenate "in toto", non-synaptic mitochondrial fraction and synaptosomal fraction isolated from different rat brain areas (cerebral cortex, hippocampu...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971361
更新日期:1987-01-01 00:00:00
abstract::It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0221-4
更新日期:2010-10-01 00:00:00
abstract::Treatment of neural membranes from rat cerebral cortex with phospholipase C (phosphatidylcholine cholinephosphohydrolase) inhibited the binding of radiolabelled antagonists to muscarinic acetylcholine receptors. This inhibition was incomplete, was not competitive, and did not appear to be related to the production of ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964517
更新日期:1984-05-01 00:00:00
abstract::After rapid inactivation of the enzymes responsible for glucose metabolism by microwave irradiation, concentrations of glucose in 20 regions of the mouse brain were estimated with combined gas chromatography-mass spectrometry (GC-MS). The highest concentrations of glucose were found in the periventricular nuclei of th...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00963774
更新日期:1977-12-01 00:00:00
abstract::During pregnancy, emergence of endogenous opioid inhibition of oxytocin neurons is revealed by increased oxytocin secretion after administration of the opioid receptor antagonist, naloxone. Here we show that prolonged estradiol-17beta and progesterone treatment (mimicking pregnancy levels) potentiates naloxone-induced...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9506-7
更新日期:2008-04-01 00:00:00
abstract::To clarify the molecular basis of the cytoprotective properties of immunophilin ligands (IPLs), the anti-apoptotic effects of IPLs were determined in human glioma U251 cells. GPI1046 and V10367, non-immunosuppressive IPLs (NI-IPLs), as well as FK506, an immunosuppressive IPL (I-IPL), had cytoprotective effects against...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000029565.92587.25
更新日期:2004-08-01 00:00:00
abstract::Bilateral injection of 6-hydroxydopamine into the medial forebrain bundle (MFB) significantly decreased monoamine concentrations in the hypothalamus. The noradrenaline and serotonin content of the paraventricular nucleus (PVN) was also significantly reduced. These drastic decreases in neurotransmitter concentration di...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01474679
更新日期:1993-02-01 00:00:00
abstract::Endoplasmic reticulum (ER) and mitochondria are intracellular organelles and their interactions are directly involved in different processes such as Ca(2+) signaling in cell survival and death mechanisms. Bcl-2 is an anti-apoptotic protein intrinsically related to ER and mitochondria, modulating Ca(2+) content in thes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0600-5
更新日期:2012-02-01 00:00:00