Abstract:
:The potassium A-current (IK(A)) is important in regulating the membrane potential between action potentials. The whole-cell patch-clamp technique was applied to cultured Drosophila neurons derived from embryonic neuroblasts. IK(A) was measured from neurons before and after application of 0.1 mM lanthanum to the external saline. IK(A) was smaller in the lanthanum-containing saline (7+/-1 pA) than in the control saline (34+/-6 pA). Activation and inactivation of IK(A) were unchanged by lanthanum. These results suggest that lanthanum neurotoxicity may lead to increased neuronal excitability. Moreover, given this inhibition of IK(A), lanthanum should not be used to block calcium current in studies of K+ currents.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Alshuaib WB,Mathew MVdoi
10.1007/s11064-005-7412-4keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1087-92issue
9eissn
0364-3190issn
1573-6903journal_volume
30pub_type
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