Changes of ATP and ADP in cultured astrocytes under and after in vitro ischemia.

abstract：:The current studies focus on what mechanisms regulate the concentration of PLP mRNA in cells. The PLP mRNA is very stable and these studies suggest that its stability is regulated by a trans-acting factor specific to oligodendrocytes. In order to test whether the 3'untranslated region (3'UTR) of the PLP mRNA might reg...

journal_title：Neurochemical research

authors： Mallon BS,Macklin WB

更新日期：2002-11-01 00:00:00

abstract：:The current study investigated the neuroprotective activity of idebenone against pilocarpine-induced seizures and hippocampal injury in rats. Idebenone is a ubiquinone analog with antioxidant, and ATP replenishment effects. It is well tolerated and has low toxicity. Previous studies reported the protective effects of ...

journal_title：Neurochemical research

authors： Ahmed MA

更新日期：2014-02-01 00:00:00

abstract：:The tyrosine phosphatase inhibitor BpV(phen) stimulated a concentration-dependent increase of phospholipase C (PLC) activity in bovine adrenal medullary chromaffin cells. This response was accompanied by an increase in PLCgamma1 tyrosine phosphorylation and its cytosketetal translocation. Insulin, at high concentratio...

journal_title：Neurochemical research

authors： Roberts-Thomson EL,Herd LM,Saunders HI,Dunkley PR,Bunn SJ

更新日期：2004-10-01 00:00:00

abstract：:Proteasome inhibition has been observed in many neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Here, the effect of proteasome inhibition on the morphology of cultured rat cortical astrocytes was investigated. Increasing evidence suggests that the function of astrocytes is related close...

journal_title：Neurochemical research

authors： Ren QG,Yu Y,Pan DJ,Luo X,Wang XZ,Wang W

更新日期：2009-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a common progressive neurodegenerative disorder, for which at present no causal treatment is available. On the understanding that the causes of PD are mainly oxidative stress and mitochondrial dysfunction, antioxidants and other drugs are expected to be used. In the present study, we demons...

journal_title：Neurochemical research

authors： Jimenez-Del-Rio M,Guzman-Martinez C,Velez-Pardo C

更新日期：2010-02-01 00:00:00

abstract：:In this study, we observed the effects of metformin, one of the most widely prescribed drugs for the treatment of type 2 diabetes, on cell proliferation and neuroblast differentiation in the subgranular zone of the hippocampal dentate gyrus (SZDG) in Zucker diabetic fatty (ZDF) rats, which are a model for type 2 diabe...

journal_title：Neurochemical research

authors： Hwang IK,Kim IY,Joo EJ,Shin JH,Choi JW,Won MH,Yoon YS,Seong JK

更新日期：2010-04-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) activity and levels of tyrosine were measured in whole brains from mice subjected to brief electric foot shock or to single or multiple injections of hydrocortisone acetate (HCA; 20 mg/kg). Adult brain tyrosine levels showed a rapid increase after either foot shock or a single injection of HC...

journal_title：Neurochemical research

authors： Diez JA,Sze PY,Ginsburg BE

更新日期：1977-04-01 00:00:00

abstract：:The ketone body, β-hydroxybutyrate (βOHB), is metabolised by the brain alongside the mandatory brain fuel glucose. To examine the extent and circumstances by which βOHB can supplement glucose metabolism, we studied guinea pig cortical brain slices using increasing concentrations of [U-13C]D-βOHB in conjunction with [1...

journal_title：Neurochemical research

authors： Achanta LB,Rowlands BD,Thomas DS,Housley GD,Rae CD

更新日期：2017-06-01 00:00:00

abstract：:Recently we have demonstrated that extracellular ATP acts as an excitatory neurotransmitter and enhances cell death in the presence of ferrous ions. By using a newly developed cis-parinaric acid fluorescence technique, we demonstrated that ATP, in a dose dependent manner, enhanced the increased membrane lipid peroxida...

journal_title：Neurochemical research

authors： Cheng Y,Chen M,James-Kracke M,Wixom P,Sun AY

更新日期：1996-01-01 00:00:00

abstract：:Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...

journal_title：Neurochemical research

authors： Maliszewski-Hall AM,Alexander M,Tkáč I,Öz G,Rao R

更新日期：2017-01-01 00:00:00

abstract：:The changes in both the levels of some free amino acids and their metabolism in the rat brain during the first 24 hr of postnatal life were studied. The content of glutamic acid decreased for the first 2 hr; it remained at the lowest level for the next 4 hr, when it began to increase. The content of alanine decreased ...

journal_title：Neurochemical research

authors： Noguchi T,Nomura M,Tsukada Y

更新日期：1980-10-01 00:00:00

abstract：:The present study was designed to evaluate the potential role of miR-93 in cerebral ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice via middle cerebral artery occlusion (MCAO) for 1 h followed by reperfusion. And miR-93 antagomir was transfected to down-regulate the miR-93 le...

journal_title：Neurochemical research

authors： Wang P,Liang X,Lu Y,Zhao X,Liang J

更新日期：2016-10-01 00:00:00

abstract：:Beta-amyloid (Abeta) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Abeta on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Abeta(25-35) at 3 and 10 microM for 12 and 24 h followed by...

journal_title：Neurochemical research

authors： Buntup D,Skare O,Solbu TT,Chaudhry FA,Storm-Mathisen J,Thangnipon W

更新日期：2008-02-01 00:00:00

abstract：:A cortical cup model with continuous perfusion of artificial cerebrospinal fluid (containing 134 mM NaCl) was used to investigate the effects of anion channel blockers on the hyposmotically-induced release of amino acids from the in vivo rat cerebral cortex. The hyposmotic stimulus (25 mM NaCl) evoked a release of tau...

journal_title：Neurochemical research

authors： Estevez AY,O'Regan MH,Song D,Phillis JW

更新日期：1999-03-01 00:00:00

abstract：:Serotonin-synthesizing raphé/parapyramidal neurons (5-HT neurons) may function as sympathetic premotor neurons regulating sympathetic outflow to the cutaneous vascular bed. In the present study a genetically engineered pseudorabies virus (PRV) expressing green fluorescent protein (GFP) was injected into the rat tail. ...

journal_title：Neurochemical research

authors： Tóth IE,Tóth DE,Boldogkoi Z,Hornyák A,Palkovits M,Blessing WW

更新日期：2006-02-01 00:00:00

abstract：:The exposure to hypobaric hypoxia increased lipid peroxidation as indicated by thiobarbituric acid-reactive substances [TBARS] in rat brain. Plasma lactate/pyruvate ratio was used as a marker of hypoxia. We compared the protective effect of alpha-tocopherol with the effect of L-carnitine or phosphocreatine. Rats pretr...

journal_title：Neurochemical research

authors： Rauchová H,Koudelová J,Drahota Z,Mourek J

更新日期：2002-09-01 00:00:00

abstract：:Ethylcholine mustard aziridinium ion (ECMA) was infused intracerebroventricularly (icv) to rats followed by measurement of two markers of presynaptic cholinergic neurons, choline acetyltransferase (ChAT) activity and high affinity choline transport (HAChT), in the hippocampus and cortex. Bilateral icv administration o...

journal_title：Neurochemical research

authors： Johnson GV,Simonato M,Jope RS

更新日期：1988-08-01 00:00:00

abstract：:One of the main pathological symptoms of early diabetic retinal neuropathy is retina neuronal apoptosis. In the present work we investigated the effects of indoleamine hormone melatonin, a powerful free radical scavenger, on streptozotocin-induced retina neuronal cell apoptosis in high blood glucose rat. After melaton...

journal_title：Neurochemical research

authors： Li X,Zhang M,Tang W

更新日期：2013-03-01 00:00:00

abstract：:Ciliary ganglion neurons and nonneurons can be separated from each other, based on the greater adhesivity of the nonneurons to untreated tissue culture plastic in the presence of serum. When the separation was carried out in the presence of Serum Plus (a commercially available supplemented serum), two populations of n...

journal_title：Neurochemical research

authors： Needels DL,Nieto-Sampedro M,Cotman CW

更新日期：1987-10-01 00:00:00

abstract：:The vesicular hypothesis has stimulated fruitful investigations on many secreting systems. In the case of rapid synaptic transmission, however, the hypothesis has been found difficult to reconcile with a number of well established observations. Brief impulses of transmitter molecules (quanta) are emitted from nerve te...

journal_title：Neurochemical research

authors： Dunant Y,Israël M

更新日期：1998-05-01 00:00:00

abstract：:The effects of the following drugs: nimodipine (1 mg/kg b.w., i.p.), 2-amino-5-phosphonovaleric acid (4 mg/kg b.w., i.p.) and propentofylline (25 mg/kg b.w., i.p.), administered (alone or in combination) at the end of 15 min bilateral ischemia in gerbils were evaluated on mitochondrial superoxide dismutase (SOD), glut...

journal_title：Neurochemical research

authors： Stanimirovic DB,Micic DV,Markovic M,Spatz M,Mrsulja BB

更新日期：1994-02-01 00:00:00

abstract：:The participation of voltage-sensitive Na+ channels (VSSC) on the changes on internal (i) Na+, K+, Ca2+, and on DA, Glu, and GABA release caused by different concentrations of 4-AP was investigated in striatum synaptosomes. TTX, which abolished the increase in Na(i) (as determined with SBFI), induced by 0.1 mM 4-AP on...

journal_title：Neurochemical research

authors： Galván E,Sitges M

更新日期：2004-02-01 00:00:00

abstract：:Uridine, a pyrimidine nucleoside, has been proposed to be a potential signaling molecule in the central nervous system. The understanding of uridine release in the brain is therefore of fundamental importance. The present study was performed to determine the characteristics of basal and morphine-induced uridine releas...

journal_title：Neurochemical research

authors： Song W,Wu CF,Liu P,Xiang RW,Wang F,Dong YX,Yang JY

更新日期：2013-01-01 00:00:00

abstract：:Senescence of the central nervous system is characterized by a progressive loss of neurons that can result in physiological and behavioral impairments. Reduction in the levels of central neurotrophic factors or of neurotrophin receptors may be one of the causes of the onset of these degenerative events. Thus, a proper...

journal_title：Neurochemical research

authors： Taglialatela G,Navarra D,Olivi A,Ramacci MT,Werrbach-Perez K,Perez-Polo JR,Angelucci L

更新日期：1995-01-01 00:00:00

abstract：:Omega-conotoxin GVIA (omega-CTX), as a selective blocker for an N-type Ca2+ channel, has been conveniently used in many molecular biochemical and pharmacological experiments. There has been little elucidation of 125I-omega-CTX binding sites (mainly the 135-kDa band) in the crude membranes from chick brain, although th...

journal_title：Neurochemical research

authors： Wada T,Abe J,Minami T,Masuko T,Ichida S

更新日期：2003-05-01 00:00:00

abstract：:The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...

journal_title：Neurochemical research

authors： Zhu MY,Kyle PB,Hume AS,Ordway GA

更新日期：2004-02-01 00:00:00

abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...

journal_title：Neurochemical research

authors： Xu J,Song D,Xue Z,Gu L,Hertz L,Peng L

更新日期：2013-03-01 00:00:00

abstract：:Lipid synthesis from acetoacetate and 3-hydroxybutyrate was studied in chick embryo from 15 to 21 days and in chick neonate from 1 to 21 days. Embryonic spinal cord showed higher ability than brain to incorporate acetoacetate into total lipids, although a sharp decrease was found at hatching. 3-Hydroxybutyrate incorpo...

journal_title：Neurochemical research

authors： Linares A,Caamaño GJ,Diaz R,Gonzalez FJ,Garcia-Peregrin E

更新日期：1993-10-01 00:00:00

abstract：:We describe an attempt to incorporate a metabolically inert phospholipid analog into animal membranes, especially myelin, in vivo, with the view of eventual long-term membrane modification or membrane engineering. A sonicated suspension of a mixture of [14C]phosphatidylcholine and its dialkyl analog, [3H] tetradecylo...

journal_title：Neurochemical research

authors： Brockerhoff H,Wisniewski HM,Lipton LC,Deshmukh DS

更新日期：1980-06-01 00:00:00

abstract：:Malformations of cortical development (MCD) are critical brain development disorders associated with varied abnormalities in both anatomic structures and neural functioning. It is also a very common etiology to the epilepsy, in which the alteration on excitability of cortical neurons is hypothesized as one of importan...

journal_title：Neurochemical research

authors： Wang Y,Sun D,Yue Z,Tang W,Xiao B,Feng L

更新日期：2016-09-01 00:00:00