Abstract：
:Tyrosine hydroxylase (TH) activity and levels of tyrosine were measured in whole brains from mice subjected to brief electric foot shock or to single or multiple injections of hydrocortisone acetate (HCA; 20 mg/kg). Adult brain tyrosine levels showed a rapid increase after either foot shock or a single injection of HCA; TH activity was also rapidly increased by foot shock but not by HCA. Multiple injections of HCA over three days increased brain TH activity in neonatal mice, but had no effect in adults. These results suggest that glucocorticoid hormone may have a regulatory influence on brain TH during the neonatal period, and that the hormone may also affect brain tyrosine. The acute effect of foot shock stress on brain TH activity is not a glucocorticoid-mediated event, but can be interpreted as enzyme activation due to neural stimulation.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Diez JA,Sze PY,Ginsburg BEdoi
10.1007/BF00964094subject
Has Abstractpub_date
1977-04-01 00:00:00pages
161-70issue
2eissn
0364-3190issn
1573-6903journal_volume
2pub_type
杂志文章abstract：:An in vitro procedure for labeling of RNA in the excised rat nodose ganglion was used to evaluate the changes in incorporation of [3H]uridine into ganglionic RNA following transection of the abdominal vagus nerves. Significant increases in the incorporation into 28S, 18S and 4S RNA were observed at 1 day after injury,...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00965726
更新日期：1983-03-01 00:00:00
abstract：:The kinetics of the uptake of p-tyramine, m-tyramine, and dopamine were investigated in slices of the hypothalamus and striatum of the rat in the presence of nialamide. When uptake was analyzed by a least-squares fit to a Lineweaver-Burk plot, each amine appeared to be concentrated by both a "low"-affinity and a "high...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964440
更新日期：1979-10-01 00:00:00
abstract：:"Kindling" is a phenomenon of epileptogenesis, which has been widely used as an experimental model of temporal lobe epilepsy. At the present work we investigated the contribution of NMDA receptors in the Pentylenetetrazol-induced "kindling" model in the mouse brain, by using quantitative autoradiography and the radioa...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1021143813935
更新日期：1999-12-01 00:00:00
abstract：:Turnover rate of individual molecular species of sphingomyelin of adult rat brain myelin and microsomal membranes was determined after an intracerebral injection of 100 microCi of [C3H3]choline. Myelin and microsomal membrane sphingomyelins were isolated from the rest of the lipids. The individual molecular species of...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964414
更新日期：1981-10-01 00:00:00
abstract：:Complementary DNA (cDNA) clones containing the entire coding sequence for Diazepam Binding Inhibitor (DBI) peptide, a 10-kDa precursor of putative natural ligands of benzodiazepine recognition sites, were isolated from rat, human and cow libraries. The sequence of all these clones is highly conserved; however, the N-t...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/BF00972202
更新日期：1990-02-01 00:00:00
abstract：:Subunit-specific antibodies to all the gamma subunit isoforms described in mammalian brain (gamma(1), gamma(2S), gamma(2L), and gamma(3) have been made. The proportion of GABA(A) receptors containing each gamma subunit isoform in various brain regions has been determined by quantitative immunoprecipitation. In all tes...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02529132
更新日期：1996-02-01 00:00:00
abstract：:Ion channels are targets of various antiepileptic drugs. In cerebral presynaptic nerve endings Na(+) and Ca(2+) channels are particularly abundant, as they control neurotransmitter release, including the release of glutamate (Glu), the most concentrated excitatory amino acid neurotransmitter in the brain. Several pre-...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-015-1749-0
更新日期：2016-04-01 00:00:00
abstract：:Metabotropic glutamate receptors (mGluR) play a role in synaptic transmission, neuronal modulation and plasticity but their action in epileptic activity is still controversial. On the other hand adenosine acts as a neuromodulator with endogenous anticonvulsive properties. Since cerebellum from epileptic patients has s...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-006-9275-8
更新日期：2007-07-01 00:00:00
abstract：:The putative dopamine D4 receptor protein in rat brain was labelled and quantified autoradiographically using two selective benzamides: [3H]YM-09151-2 which labels D2, D3 and D4 dopamine receptors and [3H]Raclopride which labels D2 and D3. The difference in densities of both ligands at saturable concentrations, show a...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027399408608
更新日期：1997-04-01 00:00:00
abstract：:In this review article, we summarize recently accumulated knowledge regarding the molecular mechanisms, which control retinal development. Retinal neurons are born in two waves of cytogenesis. In the first wave, neurons of cone circuitry are generated, whereas in the second wave, rod circuitry is added. Neurons genera...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1023/a:1007696112956
更新日期：2000-10-01 00:00:00
abstract：:Estrogen action is necessary for evidencing the stimulatory action of mifepristone and naloxone on prolactin (PRL) secretion during late pregnancy. Our aim is to determine the mechanism mediating this facilitator action of estrogens. To investigate the hypothalamic mechanisms involved in estrogen actions in PRL secret...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-2067-x
更新日期：2016-12-01 00:00:00
abstract：:Fecal incontinence and constipation still remain the major complications after procedures for anorectal malformations (ARMs). Previous studies have demonstrated a decrease of neural cell in lumbosacral spinal cord of ARMs patients and rat models. However, the underlying mechanism remains elusive. In this study, the ne...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-017-2354-1
更新日期：2017-11-01 00:00:00
abstract：:This study attempted to investigate the possible involvement of the brain stem noradrenergic system in the development of hypertension in spontaneously hypertensive rats. Steady-state norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid concentrations and norepinephrine turnover were determined in the in...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969761
更新日期：1989-01-01 00:00:00
abstract：:The anterograde axonal transport of choline-phosphoglycerides was studied in sciatic nerve motoneurons of adult (3-month-old) and aged (24-month-old) rats. After the spinal cord injection of [2-3H]glycerol, choline-phosphoglycerides; the major phospholipid class was transported along the nerve. The axonal transport ra...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00971365
更新日期：1987-01-01 00:00:00
abstract：:The primary objective of this investigation was to assess the neuroprotective efficacy of spice active principles namely Eugenol (Eug) and isoeugenol (IE) in an acrylamide (ACR) neuropathy model in rats. In the present study, ACR administration (50 mg/kg bw, i.p. 3 times/week) for 5 weeks to growing rats caused typica...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-012-0924-9
更新日期：2013-02-01 00:00:00
abstract：:The effects of delta 9-tetrahydrocannabinol (delta 9-THC) administration on the central serotoninergic system were evaluated by biochemical assays of tissue levels of indoleamines; a measure of the serotonin (5-HT) innervation was obtained by using [3H]paroxetine as a marker of 5-HT uptake sites. Two different delta 9...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00978372
更新日期：1993-11-01 00:00:00
abstract：:Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-014-1407-y
更新日期：2014-11-01 00:00:00
abstract：:The study provides detailed biochemical correlates to the common histopathological diagnoses in epilepsy. A dot immunobinding procedure was used for quantification of NSE, GFA, S-100, NCAM, NF 68 and NF 200. The material consisted of samples from 48 patients either selected for surgical treatment of partial epilepsy o...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00967255
更新日期：1993-04-01 00:00:00
abstract：:The effect of maternal hypoxia on the modification of the fetal brain cell membrane N-methyl-D-aspartate (NMDA) receptor and its modulatory sites was investigated. Experiments were conducted in pregnant guinea pigs of 60 days of gestation. Guinea pig fetuses were exposed to maternal hypoxia (FiO2 = 7%) for 60 minutes....
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00968402
更新日期：1992-12-01 00:00:00
abstract：:Somatostatin (SS) is an inhibitory regulator of secretory and proliferative responses that activates a group of receptors in the plasma membrane termed SSR1-5. SSR2 is one of the most abundant SSR, which also is expressed in high numbers in many neuroendocrine tumor types. Here, we describe a study of the presence and...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1022848718109
更新日期：2003-04-01 00:00:00
abstract：:Blue light impinging on the many mitochondria associated with retinal ganglion cells (RGCs) in situ has the potential of eliciting necroptosis through an action on RIP1/RIP3 to stimulate RGC death in diseases like glaucoma and diabetic retinopathy. Cells in culture die when exposed to blue light. The death process is ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1946-5
更新日期：2016-09-01 00:00:00
abstract：:This work evaluated the in vitro effect of thiazolidin-4-ones on the activity of AChE (total and isoforms) isolated from the cerebral cortex, hippocampus, and lymphocytes. Kinetic parameters were evaluated and molecular docking was performed. Our results showed that thiazolidinones derived from 4-(methylthio)benzaldeh...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-019-02929-8
更新日期：2020-02-01 00:00:00
abstract：:The presynaptic dopamine (DA) D2 receptor-mediated regulation of ATP-sensitive potassium (K+ATP) channels was examined in slices of the rat caudate-putamen. When slices were incubated with the specific D2 receptor antagonist (-)-sulpiride (SLP), a concentration-dependent increase of extracellular DA release was observ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1026620316090
更新日期：2000-12-01 00:00:00
abstract：:Excessive hyperbilirubinemia can cause irreversible neurological damage in the neonatal period. However, the complete understanding of the pathogenesis of unconjugated bilirubin (UCB) encephalopathy remains a matter of debate. This study investigates whether UCB inhibits the endocytosis of cationized ferritin (CF) by ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1011608017870
更新日期：2001-07-01 00:00:00
abstract：:The present study examined the potential membrane retention of desipramine (DMI) following exposures of 293-hNET cells to DMI, and its effect on [3H]NE uptake. Incubation of cells with 500 nM DMI for 1 h or 1 day persistently inhibited the uptake of [3H]NE up to 7 days, despite daily repeated washing of cells with dru...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/b:nere.0000013747.04964.46
更新日期：2004-02-01 00:00:00
abstract：:The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...
journal_title：Neurochemical research
pub_type： 杂志文章,评审
doi：10.1007/s11064-010-0291-3
更新日期：2011-04-01 00:00:00
abstract：:Recent evidence reveals that prolactin gene expression (PRL-GE) in mammotropes occurs in pulses, but the molecular process(es) underlying this phenomenon remains unclear. Earlier, we have identified an E-box (E-box133) in the rat PRL promoter that binds several circadian elements and is critical for this dynamic proce...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/s11064-016-1843-y
更新日期：2016-06-01 00:00:00
abstract：:Rat tissues were tested for their ability to inhibit the binding of [3H]dihydromorphine or [3H]naloxone to membrane-bound opiate receptors. By this criterion, morphine-like substances were found in lung, heart, liver, and kidney as well as in brain. The relative activity of the extracts, based on initial tissue weight...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00963809
更新日期：1979-06-01 00:00:00
abstract：:A Zn(2+)-glycerophosphocholine cholinephosphodiesterase was purified with a specific activity of 4.6 mumole/min.mg protein from bovine brain membranes by procedures involving PI-PLC solubilization, concanavalin A affinity chromatography, CM-sephadex chromatography and Sephadex G-150 chromatography. Based on molecular ...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF02532395
更新日期：1996-10-01 00:00:00
abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...
journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00969632
更新日期：1989-02-01 00:00:00
