SSR2(a) receptor expression and adrenergic/cholinergic characteristics in differentiated SH-SY5Y cells.

abstract：:VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors an...

journal_title：Neurochemical research

authors： Mizoguchi T,Shimazawa M,Ohuchi K,Kuse Y,Nakamura S,Hara H

更新日期：2019-02-01 00:00:00

abstract：:More than a decade has passed since Zic family zinc finger proteins were discovered to be transcription factors controlling neuroectodermal differentiation (neural induction) in Xenopus laevis embryos. Although BMP-signal blocking has been shown to be a major upregulator of Zic genes in neuroectodermal differentiation...

journal_title：Neurochemical research

authors： Aruga J,Mikoshiba K

更新日期：2011-07-01 00:00:00

abstract：:α-Synuclein (α-Syn) plays a crucial role in the pathophysiology of Parkinson's disease (PD), the degeneration of dopaminergic neurons. Previous studies have shown that α-Syn regulates dopamine synthesis by binding to and inhibiting tyrosine hydroxylase (TH). In neurons, protein phosphatases (PPs) play a prominent role...

journal_title：Neurochemical research

authors： Hua G,Xiaolei L,Weiwei Y,Hao W,Yuangang Z,Dongmei L,Yazhuo Z,Hui Y

更新日期：2015-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the aged population. Early-onset familial AD (FAD) involves mutations in a gene on chromosome 21 encoding the amyloid protein precursor or on chromosomes 14 or 1 encoding genes known as presenilins. All mutations examined have been found to increase the p...

journal_title：Neurochemical research

authors： Small DH

更新日期：1998-05-01 00:00:00

abstract：:Exercise has been regarded as an effective rehabilitation strategy to facilitate motor and cognitive functional recovery after stroke, even though the complex effects associated with exercise-induced repair of cerebral ischemic injury are not fully elucidated. The enhancement of angiogenesis and neurogenesis, and the ...

journal_title：Neurochemical research

authors： Chen Z,Hu Q,Xie Q,Wu S,Pang Q,Liu M,Zhao Y,Tu F,Liu C,Chen X

更新日期：2019-04-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:Using a model of middle cerebral artery occlusion (MCAO), we have previously demonstrated that treadmill exercise promotes angiogenesis in the ischemic penumbra through caveolin-1/VEGF signaling pathways. However, the function of caveolin-1/VEGF signaling in neurogenesis after MCAO has not been determined. In this stu...

journal_title：Neurochemical research

authors： Zhao Y,Pang Q,Liu M,Pan J,Xiang B,Huang T,Tu F,Liu C,Chen X

更新日期：2017-02-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...

journal_title：Neurochemical research

authors： Li S,Wang D,Tian Y,Wei H,Zhou Z,Liu L,Wang D,Dong JF,Jiang R,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:A very large body of evidence from in vivo studies has been accumulated on a link between the change of energy and cell survival/apoptosis. Using an in vitro ischemia model, we have previously shown that ischemia could induce apoptosis in astrocytes. In this study, we utilized the same in vitro model to investigate ch...

journal_title：Neurochemical research

authors： Yu AC,Lau AM,Fu AW,Lau LT,Lam PY,Chen XQ,Xu ZY

更新日期：2002-12-01 00:00:00

abstract：:The activation of caspase-3 is considered to be a reliable marker for apoptotic cell death, and a 120-kDa fragment of αII-spectrin is generated by caspase-3 mediated cleavage of this structural protein. In the present study, we compared cleaved αII-spectrin (120-kDa) and cleaved caspase-3-immunoreactive cells and thei...

journal_title：Neurochemical research

authors： Hwang IK,Ahn JH,Yoo DY,Lee CH,Yoo KY,Choi JH,Moon SM,Shin HC,Won MH

更新日期：2012-03-01 00:00:00

abstract：:Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in s...

journal_title：Neurochemical research

authors： Rajesh V,Ilanthalir S

更新日期：2016-10-01 00:00:00

abstract：:With the aid of histochemical and electrophoretic techniques activities for esterase and esterprotease were investigated in the digastric and masseter muscles from normal and dystrophic mice. The substrates used were alpha-naphthyl acetate and N-acetyl-L-alanine alpha-naphthyl ester. According to the microscopic obser...

journal_title：Neurochemical research

authors： Kirkeby S,Moe D,Vilmann H

更新日期：1989-03-01 00:00:00

abstract：:Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-old rats and lowest in adults, while the density of muscarinic binding...

journal_title：Neurochemical research

authors： Balduini W,Costa LG,Murphy SD

更新日期：1990-01-01 00:00:00

abstract：:5- and 6-Hydroxydopamine, which we had earlier identified as naturally occurring amines in human urine, were quantified in Parkinson's patients treated with L-DOPA, Parkinson's patients whose treatment did not include L-DOPA and in age matched controls. Analysis was carried out by GC-MS of the ditrifluoromethylbenzoyl...

journal_title：Neurochemical research

authors： Andrew R,Watson DG,Best SA,Midgley JM,Wenlong H,Petty RK

更新日期：1993-11-01 00:00:00

abstract：:Sandhoff disease is an incurable neurodegenerative disorder caused by mutations in the lysosomal hydrolase β-hexosaminidase. Deficiency in this enzyme leads to excessive accumulation of ganglioside GM2 and its asialo derivative, GA2, in brain and visceral tissues. Small molecule inhibitors of ceramide-specific glucosy...

journal_title：Neurochemical research

authors： Arthur JR,Wilson MW,Larsen SD,Rockwell HE,Shayman JA,Seyfried TN

更新日期：2013-04-01 00:00:00

abstract：:It has been reported that central dopaminergic system is implicated in the mechanism underlying general anesthesia. Whether dopamine (DA) neurons in midbrain ventral periaqueductal gray (vPAG) are involved in general anesthesia and how general anesthetics affect these neurons remain sparsely documented. To determine t...

journal_title：Neurochemical research

authors： Li J,Yu T,Shi F,Zhang Y,Duan Z,Fu B,Zhang Y

更新日期：2018-04-01 00:00:00

abstract：:The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic ac...

journal_title：Neurochemical research

authors： Szabó G,Kovács GL,Baláspiri L,Telegdy G

更新日期：1986-12-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain has been described as an animal model of depressive behavior that consumes significantly greater amounts of alcohol compared to the Wistar (WIS) rat strain. Since the mesolimbic dopamine (DA) type-2 (D2) receptors mediate reward-related behaviors, the present study measured the bindin...

journal_title：Neurochemical research

authors： Morganstern I,Tejani-Butt S

更新日期：2010-11-01 00:00:00

abstract：:Isozyme patterns of cholinesterase (ChE) from heart, tongue, and skeletal muscle of normal and dystrophic hamsters are presented. Two principal bands, bands 1 and 2, were evaluated. Band 1 migrates faster towards the anode than does band 2. While bands 1 and 2 stain for AChE and were found in control muscles, only ban...

journal_title：Neurochemical research

authors： Henderson NS,Tweedle CD,Kabara JJ

更新日期：1980-12-01 00:00:00

abstract：:The lysosomal degradation of several sphingolipids requires the presence of four small glycoproteins called saposins, generated by proteolytic processing of a common precursor, prosaposin. Saposins share several structural properties, including six similarly located cysteines forming three disulfide bridges with the s...

journal_title：Neurochemical research

authors： Vaccaro AM,Salvioli R,Tatti M,Ciaffoni F

更新日期：1999-02-01 00:00:00

abstract：:Systemic inflammation triggered by lipopolysaccharide (LPS) administration disrupts blood-brain barrier (BBB) homeostasis in animal models. This event leads to increased susceptibility of several encephalic structures to potential neurotoxicants present in the bloodstream. In this study, we investigated the effects of...

journal_title：Neurochemical research

authors： Gonçalves C,Dos Santos DB,Portilho SS,Lopes MW,Ghizoni H,de Souza V,Mack JM,Naime AA,Dafre AL,de Souza Brocardo P,Prediger RD,Farina M

更新日期：2018-03-01 00:00:00

abstract：:Ischemic brain injury continues to be of major concern in patients undergoing cardiopulmonary bypass (CPB) surgery for congenital heart disease. Striatum and hippocampus are particularly vulnerable to injury during these processes. Our hypothesis is that the neuronal injury resulting from CPB and the associated circul...

journal_title：Neurochemical research

authors： Pastuszko P,Schears GJ,Greeley WJ,Kubin J,Wilson DF,Pastuszko A

更新日期：2014-11-01 00:00:00

abstract：:Ciliary ganglion neurons and nonneurons can be separated from each other, based on the greater adhesivity of the nonneurons to untreated tissue culture plastic in the presence of serum. When the separation was carried out in the presence of Serum Plus (a commercially available supplemented serum), two populations of n...

journal_title：Neurochemical research

authors： Needels DL,Nieto-Sampedro M,Cotman CW

更新日期：1987-10-01 00:00:00

abstract：:Exposure of guinea pig brain slices to low concentrations (10 microM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher concentrations caused further increases in lactate and decreases in N...

journal_title：Neurochemical research

authors： Thatcher NM,Badar-Goffer RS,Ben-Yoseph O,McLean MA,Morris PG,Prior MJ,Taylor A,Bachelard HS

更新日期：2002-02-01 00:00:00

abstract：:Guanine nucleotides (GN) have been implicated in many intracellular mechanisms. Extracellular actions, probably as glutamate receptor antagonists, have also been recently attributed to these compounds. GN may have a neuroprotective role by inhibiting excitotoxic events evoked by glutamate. Effects of extracellular GN ...

journal_title：Neurochemical research

authors： Tasca CI,Souza DO

更新日期：2000-02-01 00:00:00

abstract：:A synthetic peptide corresponding to the first 28 amino acids of the Alzheimer disease amyloid beta/A4 peptide (3.2 kDa) aggregated to a high molecular weight (15 kDa) on SDS/urea polyacrylamide gels. Proteinase K, V8 protease, trypsin, and endopeptidase Lys-C readily degraded the aggregate. By contrast, when digested...

journal_title：Neurochemical research

authors： Honda T,Marotta CA

更新日期：1992-04-01 00:00:00

abstract：:T-588(R(-)-1-(benzo(b)thiophen-5yl)-2-[2(N,N-diethylamino)ethoxy]ethanol hydrochloride) is a novel compound which has been shown to exhibit a wide range of neurotrophic effects both in vivo and in vitro. This compound can slow the motor deterioration of wobbler mouse motor neuron disease. However, it is not known whet...

journal_title：Neurochemical research

authors： Iwasaki Y,Ikeda K,Ichikawa Y,Igarashi O,Kinoshita M,Marubuchi S,Ono S

更新日期：2002-03-01 00:00:00

abstract：:The importance of astrocytic K(+) uptake for extracellular K(+) ([K(+)](e)) clearance during neuronal stimulation or pathophysiological conditions is increasingly acknowledged. It occurs by preferential stimulation of the astrocytic Na(+),K(+)-ATPase, which has higher K(m) and V(max) values than its neuronal counterpa...

journal_title：Neurochemical research

authors： Xu J,Song D,Xue Z,Gu L,Hertz L,Peng L

更新日期：2013-03-01 00:00:00

abstract：:Epileptogenesis, induced by status epilepticus (SE), is a chronic process, and intervention in this progress may prevent chronic epilepsy. It has been proposed that DNA methylation might be related with epileptogenesis. RASgrf1 has a differentially methylated region at the promoter which can silence gene expression. W...

journal_title：Neurochemical research

authors： Bao Y,Chen X,Wang L,Zhou J,Fu X,Wang X,Xiao Z

更新日期：2018-10-01 00:00:00

abstract：:One pathway by which tryptophan is metabolized in the brain as well as in the periphery is through cleavage of the indole ring to formylkynurenine and then kynurenine. Indoleamine-2,3-dioxygenase, the enzyme that catalyzes this cleavage, and kynurenine are distributed all across the different anatomic regions of brain...

journal_title：Neurochemical research

authors： Gál EM,Sherman AD

更新日期：1980-03-01 00:00:00