Abstract:
:The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed that D-pipecolic acid is capable of counteracting the tolerance effect of ethanol.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Szabó G,Kovács GL,Baláspiri L,Telegdy Gdoi
10.1007/BF00967746subject
Has Abstractpub_date
1986-12-01 00:00:00pages
1677-82issue
12eissn
0364-3190issn
1573-6903journal_volume
11pub_type
杂志文章abstract::Alterations in lysosomal proteases have been implicated in many neurodegenerative diseases. The current study demonstrates a concentration-dependent decrease in PC12 cell viability and transient changes in cystatin C (CYSC), cathepsin B (CATB), cathepsin D (CATD) and caspase-3 following exposure to H2O2. Furthermore, ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9338-5
更新日期:2007-09-01 00:00:00
abstract::Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spect...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1609-y
更新日期:2017-01-01 00:00:00
abstract::The microdialysis technique was used to study the effect of nitric oxide synthase (NOS) activity on taurine release. Taurine release was characterized in rat striatum that was excitotoxically lesioned compared to normal conditions. The basal taurine level of the dialysate decreased during quinolinate (QUIN) lesion in ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022418231496
更新日期:1998-04-01 00:00:00
abstract::Serotonin uptake and metabolism was studied in ependymal primary cultures. Serotonin uptake was facilitated by two different systems, one of which was the neuronal serotonin transporter SERT, exhibiting a Vmax value of 3.8+/-0.1 pmol x min(-1) x (mg protein)(-1) and an apparent Michaelis-Menten constant of 0.41+/-0.03...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000035810.08543.97
更新日期:2004-09-01 00:00:00
abstract::gamma-L-Glutamylglutamate (LGG), an endogenous constituent of the brain, reduced the glutamate-evoked increase in intracellular Ca2+ in cultured cerebellar granule cells. The extent and properties of this inhibition were different at different Mg2+ concentrations. The intracellular Ca2+ response to NMDA was slightly e...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00970596
更新日期:1995-12-01 00:00:00
abstract::Neuronal perikarya were isolated, using bulk preparative procedures, from bovine brains. Synaptosomes, neuronal perikarya, and brain homogenates had similar ganglioside patterns, with the synaptosomes containing at least four times more total ganglioside per mg protein than the neuronal perikarya and twice that of the...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966108
更新日期:1976-04-01 00:00:00
abstract::It is known that the NMDA-R NR1 subunit is needed for the receptor activity and that under hypoxia the evolution toward apoptosis or neuronal survival depends on the balance NR2A/NR2B subunits. This paper analyzes the effect of acute hypoxia on the above mentioned subunits mRNAs during development. The mean percentage...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0221-4
更新日期:2010-10-01 00:00:00
abstract::The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00966726
更新日期:1994-01-01 00:00:00
abstract::Endoplasmic reticulum (ER) and mitochondria are intracellular organelles and their interactions are directly involved in different processes such as Ca(2+) signaling in cell survival and death mechanisms. Bcl-2 is an anti-apoptotic protein intrinsically related to ER and mitochondria, modulating Ca(2+) content in thes...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0600-5
更新日期:2012-02-01 00:00:00
abstract::The tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) is not only a protein, but also a lipid phosphatase that can negatively regulate the serine/threonine kinase Akt. It has been reported that PTEN can be regulated by means of phosphorylation. However, whether PTEN can be regulated by an...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-009-9938-3
更新日期:2009-08-01 00:00:00
abstract::An in vitro model of anoxia-induced brain damage was utilized to help elucidate the biochemical basis of cell damage due to reduced oxygen availability. Previous studies suggest that anoxia-induced damage may vary presynaptically, post-synaptically or in the cell body. Thus, the consequences of an anoxic treatment inc...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00972482
更新日期:1988-04-01 00:00:00
abstract::The incorporation of [gamma-32P]ATP into proteins of rat brain polyribosomes was studied in vitro. The effects of cyclic nucleotides, calcium, hemin, ACTH, GTP, and spermine were examined. The incorporation of phosphate into proteins increased with time and phosphatase activity was very low; thus, the extent of phosph...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973039
更新日期:1984-09-01 00:00:00
abstract::It is well-known that pH changes can influence a lot of cellular processes. In this work, we have specifically studied the influence of alkalinization, which can be developed in spinal cord neurons during hyperventilation (respiratory alkalosis) and chronic renal failure (metabolic alkalosis) on calcium homeostasis. A...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/b:nere.0000035800.65411.3e
更新日期:2004-09-01 00:00:00
abstract::Uridine, a pyrimidine nucleoside, has been proposed to be a potential signaling molecule in the central nervous system. The understanding of uridine release in the brain is therefore of fundamental importance. The present study was performed to determine the characteristics of basal and morphine-induced uridine releas...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-012-0903-1
更新日期:2013-01-01 00:00:00
abstract::The pathophysiology of cerebral oedema (CE) in diabetic ketoacidosis (DKA) remains enigmatic. We investigated the role of the idiogenic osmol taurine and aquaporin channels in an in vitro model, the SH-SY5Y neuroblastoma cell line, by sequentially mimicking DKA-like hyperglycemia/hypertonicity and hypotonic fluid ther...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-011-0598-8
更新日期:2012-01-01 00:00:00
abstract::The particulars regarding the amine precursor therapy for treatment of neuropsychiatric disorders and their neurochemical background are described historically. Furthermore, peculiar or artificial amino acids which are metabolized into the brain amine or their derivatives and promised their clinical application are al...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/BF02529142
更新日期:1996-02-01 00:00:00
abstract::In the present study, we evaluated the expression of some proliferation and differentiation markers in 15 DIV astrocyte cultures pretreated or not with 0.5 mM glutamate for 24 h and than maintained under chronic or acute treatment with 50 μM R(+)enantiomer or raceme alpha-lipoic acid (ALA). GFAP expression significant...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-010-0256-6
更新日期:2010-12-01 00:00:00
abstract:: ...
journal_title:Neurochemical research
pub_type: 传,社论,历史文章
doi:10.1007/s11064-018-02702-3
更新日期:2019-01-01 00:00:00
abstract::The current study investigated the neuroprotective activity of idebenone against pilocarpine-induced seizures and hippocampal injury in rats. Idebenone is a ubiquinone analog with antioxidant, and ATP replenishment effects. It is well tolerated and has low toxicity. Previous studies reported the protective effects of ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1236-z
更新日期:2014-02-01 00:00:00
abstract::A rapid and specific method for assaying 4-aminobutyrate-2-oxoglutarate aminotransferase was developed. The method was based on the selectivity of ion exchange resin and the speed of vacuum filtration. With this new method, the aminotransferase activity in various tissues has been determined as follows: brain, 10.2; s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964061
更新日期:1978-04-01 00:00:00
abstract::Despite immense advances in the treatment strategies, the effective treatment of patients suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti-inflammatory activity. However, the role of saikosaponin a in neuropathic pain is still unclear. Therefore, the objective of this study was to inv...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-014-1407-y
更新日期:2014-11-01 00:00:00
abstract::In vitro synthesis of myelin proteolipid protein (PLP) was explored at different ages using rat brain total homogenates, incubated for 30 min with [3H]glycine. Total proteolipids, extracted from the incubated samples, were separated by SDS-PAGE and the radioactivity was measured in the band corresponding to myelin PLP...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00973044
更新日期:1984-09-01 00:00:00
abstract::The Ca(2+)-dependent release of aspartate from hippocampal preparations was first reported 35 years ago, but the functional significance of this process remains uncertain. Aspartate satisfies all the criteria normally required for identification of a CNS transmitter. It is synthesized in nerve terminals, is accumulate...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-010-0291-3
更新日期:2011-04-01 00:00:00
abstract::We have shown that acute ammonia toxicity is mediated by activation of the NMDA type of glutamate receptors. Although it is well known that L-carnitine prevents acute ammonia toxicity, the underlying molecular mechanism is not clear. We suspected that L-carnitine would prevent ammonia toxicity by preventing the toxic ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00971588
更新日期:1994-03-01 00:00:00
abstract::Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00964537
更新日期:1985-06-01 00:00:00
abstract::Tyrosinemia type II, also known as Richner-Hanhart syndrome, is an autosomal recessive inborn error of metabolism caused by a deficiency of hepatic cytosolic tyrosine aminotransferase, and is associated with neurologic and development difficulties in numerous patients. Considering that the mechanisms underlying the ne...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-013-1180-3
更新日期:2013-12-01 00:00:00
abstract::Protein kinase C (PKC) plays a key role in cellular events including proliferation, survival and differentiation. Our previous study showed the effect of phorbol 12-myristate 13-acetate (PMA), a PKC activator, inducing a decrease in retinal cells proliferation. This effect was mediated by muscarinic type 1 receptors (...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9847-x
更新日期:2009-05-01 00:00:00
abstract::Hypoxia is one of the major common components of vascular risk factors for pathogenesis of Alzheimer's disease. This study investigated the possible relationship between hypoxia and alternative splicing of the excitatory amino acid transporter 2 (EAAT2) in a transgenic model for Alzheimer's disease. We used an APP23 m...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-007-9540-5
更新日期:2008-06-01 00:00:00
abstract::A cortical cup model with continuous perfusion of artificial cerebrospinal fluid (containing 134 mM NaCl) was used to investigate the effects of anion channel blockers on the hyposmotically-induced release of amino acids from the in vivo rat cerebral cortex. The hyposmotic stimulus (25 mM NaCl) evoked a release of tau...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1020902104056
更新日期:1999-03-01 00:00:00
abstract::Development of the central somatosensory system is profoundly modulated by the sensory periphery. Cauterization of facial whiskers alters the segregation pattern of barrels in rodents only during a few days just after birth (critical period). Although a molecular basis of the segregation of barrel neurons and the crit...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1023/a:1022075508176
更新日期:1997-07-01 00:00:00