Amine precursor amino acid therapy: from neurochemical basis to clinical aspects.

abstract：:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) an...

journal_title：Neurochemical research

authors： Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SS

更新日期：2000-08-01 00:00:00

abstract：:We identify and characterize two classes of immediate-early genes: (i) genes, induced by depolarization in neurons, that play a role in depolarization-induced neuronal plasticity and (ii) genes, induced in neuronal precursors by neurotrophins, that play a causal role in neurotrophin-directed neuronal differentiation. ...

journal_title：Neurochemical research

authors： Herschman HR,Ferguson GD,Feldman JD,Farias-Eisner R,Vician L

更新日期：2000-05-01 00:00:00

abstract：:Repeated electroconvulsive shock is an effective treatment for affective disorders. Striatum, hippocampus and brainstem are involved in affective disorders. Sodium-potassium/ATPase is of paramount importance for the proper functioning of the brain and its involvement in the affective disorders has been claimed for a l...

journal_title：Neurochemical research

authors： Bignotto M,Benedito MA

更新日期：2006-04-01 00:00:00

abstract：:The goal of this study was to examine the responsiveness of an immortalized catecholaminergic neuronal line, 2N27, to various growth factors and identify those which promote catecholaminergic expression. 2N27 is a newly established neural cell line derived from fetal rat mesencephalic tissue and, thus, contains tyrosi...

journal_title：Neurochemical research

authors： Grove J,Kentroti S,Prasad K,Vernadakis A

更新日期：1997-03-01 00:00:00

abstract：:Somatostatin (SS) is an inhibitory regulator of secretory and proliferative responses that activates a group of receptors in the plasma membrane termed SSR1-5. SSR2 is one of the most abundant SSR, which also is expressed in high numbers in many neuroendocrine tumor types. Here, we describe a study of the presence and...

journal_title：Neurochemical research

authors： Hashemi SH,Li JY,Ahlman H,Dahlström A

更新日期：2003-04-01 00:00:00

abstract：:Due to the biological importance of sodium and its relative scarcity within many natural environments, 'salt appetite' has evolved whereby dietary salt is highly sought after and palatable when tasted. In addition to peripheral responses, salt depletion is detected within the brain via circumventricular organs and 11β...

journal_title：Neurochemical research

authors： Smith CM,Lawrence AJ

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to investigate potential therapeutic effects of IFN-γ primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs) transplantation on experimental autoimmune encephalomyelitis (EAE) in mice. In this study, EAE mouse model was established by MOG35-55 immunization method. Outcomes of the E...

journal_title：Neurochemical research

authors： Zhou X,Liu X,Liu L,Han C,Xie Z,Liu X,Xu Y,Li F,Bi J,Zheng C

更新日期：2020-07-01 00:00:00

abstract：:Focal epileptic seizures can in some patients be managed by inhibiting γ-aminobutyric acid (GABA) uptake via the GABA transporter 1 (GAT1) using tiagabine (Gabitril®). Synergistic anti-seizure effects achieved by inhibition of both GAT1 and the betaine/GABA transporter (BGT1) by tiagabine and EF1502, compared to tiaga...

journal_title：Neurochemical research

authors： Lie MEK,Kickinger S,Skovgaard-Petersen J,Ecker GF,Clausen RP,Schousboe A,White HS,Wellendorph P

更新日期：2020-07-01 00:00:00

abstract：:Astrocytes transport the monocarboxylate acetate, but synaptosomes do not. The reason for this is unknown, because both preparations express monocarboxylate transporters (MCT). The transport and metabolism of lactate, another monocarboxylate, was examined in these two preparations, and the results were compared to tho...

journal_title：Neurochemical research

authors： Waniewski RA,Martin DL

更新日期：2004-01-01 00:00:00

abstract：:The incubation of neuronal nitric oxide synthase with the five amyloid peptide fragments [Aβ17-21; Aβ25-29; Aβ29-33; Aβ33-37; Aβ25-37] catalyzed the formation of fibrils. The role of neuronal isomer (nNOS) involved the entrapment of free monomers and seed aggregates to initiate the events of nucleation and elongation,...

journal_title：Neurochemical research

authors： Padayachee ER,Arowolo A,Whiteley CG

更新日期：2014-01-01 00:00:00

abstract：:3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...

journal_title：Neurochemical research

authors： Tsang TM,Haselden JN,Holmes E

更新日期：2009-07-01 00:00:00

abstract：:The synthetic Liver X receptor (LXR) activator T0901317 has been reported to exert neuroprotective effect in Alzheimer's disease, but the relationship between LXR activation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) remains uncertain. This study investigated the effect of T0901317 on membrane ...

journal_title：Neurochemical research

authors： Cui W,Sun Y,Wang Z,Xu C,Xu L,Wang F,Chen Z,Peng Y,Li R

更新日期：2011-10-01 00:00:00

abstract：:The dorsal raphe nucleus (DRN) has been suggested playing an important role in the pathophysiology of post-traumatic stress disorder (PTSD), however the underlying cellular mechanisms are not fully understood. The endoplasmic reticulum (ER) is a critical organelle for synthesis of membrane and secretory proteins, and ...

journal_title：Neurochemical research

authors： Xie J,Han F,Shi Y

更新日期：2014-04-01 00:00:00

abstract：:Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been proposed as a treatment strategy for gait disorder in patients with Parkinson's disease (PD). We thus performed a systematic review and meta-analysis of randomized and nonrandomized controlled trials to assess the effect of this treatment on g...

journal_title：Neurochemical research

authors： Lin F,Wu D,Lin C,Cai H,Chen L,Cai G,Ye Q,Cai G

更新日期：2020-04-01 00:00:00

abstract：:Incomplete ischemia of the spinal cord was produced in dogs by 40 min occlusion of the abdominal aorta that was followed by 5-40 min of recirculation. Amino acid incorporation into ribosomes in vitro in the presence of venous blood sera was estimated. The most significant reduction in incorporation was produced by ser...

journal_title：Neurochemical research

authors： Chavko M,Burda J,Marsala J

更新日期：1986-06-01 00:00:00

abstract：:It was found that acute ethanol intoxication caused an imbalance of the neurotransmitters in the CNS: accumulation of GABA and serotonin and depletion of catecholamines. Alcohol depression was characterized by suppression of the evoked potentials of the various rat brain structures. Under chronic ethanol intoxication ...

journal_title：Neurochemical research

authors： Blagova OE,Budantsev AY,Sytinsky IA,Lajtha A

更新日期：1982-11-01 00:00:00

abstract：:Tanshinone I (TsI) is an important lipophilic diterpene extracted from Danshen (Radix Salvia miltiorrhizae) and has been used in Asia for the treatment of cerebrovascular diseases such as ischemic stroke. In this study, we examined the neuroprotective effect of TsI against ischemic damage and its neuroprotective mecha...

journal_title：Neurochemical research

authors： Park JH,Park Ok,Cho JH,Chen BH,Kim IH,Ahn JH,Lee JC,Yan BC,Yoo KY,Lee CH,Hwang IK,Kwon SH,Lee YL,Won MH,Choi JH

更新日期：2014-07-01 00:00:00

abstract：:VGF nerve growth factor inducible (VGF) is a neuropeptide precursor induced by brain-derived neurotrophic factor and nerve growth factor. VGF is increased in the prefrontal cortex and cerebrospinal fluid in schizophrenia patients. In our previous study, VGF-overexpressing mice exhibited schizophrenia-like behaviors an...

journal_title：Neurochemical research

authors： Mizoguchi T,Shimazawa M,Ohuchi K,Kuse Y,Nakamura S,Hara H

更新日期：2019-02-01 00:00:00

abstract：:The role of repulsive guidance molecule A (RGMa) in cerebral ischemia remains unclear. In the study, we examined the expression of RGMa in ischemic brain tissues following focal cerebral ischemia/reperfusion (IR) in rats. An established middle cerebral artery suture occlusion model was employed. A dipolar electrode wa...

journal_title：Neurochemical research

authors： Jiang F,Yin H,Qin X

更新日期：2012-09-01 00:00:00

abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...

journal_title：Neurochemical research

authors： Shen Y,Zhao H,Li P,Peng Y,Cui P,Miao F,Zhang Y,Zhang A,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Pathophysiological concentrations of branched chain keto-acids (BCKAs), such as those that occur in maple syrup urine disease, inhibit oxygen consumption in liver homogenates and brain slices and the enzymatic activity of alpha-ketoglutarate- and pyruvate dehydrogenase complexes. Consistent with previous work, studies...

journal_title：Neurochemical research

authors： Shestopalov AI,Kristal BS

更新日期：2007-04-01 00:00:00

abstract：:Changes in serotonin (5-HT) and 5-hydroxy indole acetic acid (5-HIAA), its major metabolite, in cerebral cortex, corpus striatum and hippocampus were investigated at 10th and 21st days of chronic ethanol ingestion in Wistar rats. Ethanol (7.2% v/v) was given to rats in a modified liquid diet. Biochemical analysis was ...

journal_title：Neurochemical research

authors： Uzbay IT,Usanmaz SE,Akarsu ES

更新日期：2000-02-01 00:00:00

abstract：:The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5-10 mM); a hig...

journal_title：Neurochemical research

authors： Meyer EM,Otero DH

更新日期：1989-02-01 00:00:00

abstract：:Zinc oxide nanoparticles (ZnO NPs) have diverse utility these days ranging from being part of nanosensors to be ingredient of cosmetics. Present study was designed to report the effect of variable doses of ZnO NPs on selected aspects of male albino mice behavior. Nano particles were synthesized by sol-gel auto-combust...

journal_title：Neurochemical research

authors： Zahra J,Iqbal S,Zahra K,Javed Z,Shad MA,Akbar A,Ashiq MN,Iqbal F

更新日期：2017-02-01 00:00:00

abstract：:The characteristics and properties of the increase in cytosolic [Ca2+] that occurs in bovine adrenal medullary chromaffin cells on exposure to angiotensin 11 have been investigated. In fura-2 loaded cells exposure to a maximally effective concentration of angiotensin II (100 nM) caused a rapid, but transient increase ...

journal_title：Neurochemical research

authors： Powis DA,Zerbes M,Herd LM,Dunkley PR

更新日期：2003-09-01 00:00:00

abstract：:The chemical warfare nerve agent (CWNA) soman irreversibly inhibits acetylcholinesterase (AChE) causing seizure, neuropathology and neurobehavioral deficits. Pyridostigmine bromide (PB), the currently approved pretreatment for soman, is a reversible AChE inhibitor that does not cross the blood-brain barrier (BBB) to p...

journal_title：Neurochemical research

authors： Wang Y,Wei Y,Oguntayo S,Jensen N,Doctor BP,Nambiar MP

更新日期：2011-12-01 00:00:00

abstract：:In order to develop a simplified method for long-term primary culture of highly-pure rat embryonic hippocampal neurons of low-density (10(3) cells/cm(2)), we optimized and modified conventional culturing methods. The modifications of our simplified method include: (1) combinational application of two growth substrates...

journal_title：Neurochemical research

authors： Yang H,Cong R,Na L,Ju G,You SW

更新日期：2010-09-01 00:00:00

abstract：:Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified thro...

journal_title：Neurochemical research

authors： Yarom M,Bao J,Tang XW,Wu E,Lee YH,Tsai WH,Wu JY

更新日期：1992-01-01 00:00:00

abstract：:This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice ...

journal_title：Neurochemical research

authors： Huang XF,Yu Y,Li Y,Tim S,Deng C,Wang Q

更新日期：2008-09-01 00:00:00

abstract：:The present studies examined the inhibitory effect of veratridine (a Na+ channel activator) on carbachol (a cholinergic agonist) stimulated inositol 1,3,4,5-tetrakisphosphate accumulation in rat brain cortical slices. Veratridine inhibited carbachol stimulation of inositol 1,3,4,5-tetrakisphosphate formation (after a ...

journal_title：Neurochemical research

authors： Myles ME,Gokmen-Polar Y,Fain JN

更新日期：1995-09-01 00:00:00