Abstract:
:Pig brain extracts from both soluble and membrane fractions were found to contain potent inhibitors for GABA synthesizing enzyme, GAD, referred to as endogenous GAD inhibitors (EGIs) and for the binding of GABA agonist, muscimol, referred to as muscimol binding inhibitors (MBIs). EGIs and MBIs were first purified through gel-filtration Bio-Gel P-2 columns, in which multiple activity peaks were observed. One of them appears to be co-eluted with either L-glutamate or GABA. However, others are clearly separated from L-glutamate or GABA. EGIs were found to be low MW (less than 1,800 dalton), heat and acid-base stable, negatively charged, non hydrophobic substances. MBIs were found to be low MW (less than 1,800 dalton) neutral or positively charged substances. MBIs had no effect on [3H]flunitrazepam (FNZP) binding, indicating that they are not endogenous benzodiazepine receptor ligands and they may act specifically on GABA binding site.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Yarom M,Bao J,Tang XW,Wu E,Lee YH,Tsai WH,Wu JYdoi
10.1007/BF00966871keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
107-14issue
1eissn
0364-3190issn
1573-6903journal_volume
17pub_type
杂志文章abstract::In this review properties of lipid acetyltransferase enzymes are outlined. The three activities of interest are lyso PAF acetyltransferase (acetyl CoA: 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase), AGP acetyltransferase (acetyl CoA: 1-alkyl sn-glycero-3-phosphate acetyltransferase) and a transacetylase activ...
journal_title:Neurochemical research
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journal_title:Neurochemical research
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journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF00965323
更新日期:1986-04-01 00:00:00
abstract::Regional cerebral glucose utilization (RCGU) and behavior were studied during naloxone-precipitated withdrawal in rats after chronic intravenous (IV) or intracerebroventricular (ICV) administration of sufentanil citrate, a potent, highly selective mu opiate agonist. Changes in RCGU were indistinguishable between the t...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/BF01006813
更新日期:1994-10-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:1984-12-01 00:00:00
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abstract::Lipid synthesis from acetoacetate and 3-hydroxybutyrate was studied in chick embryo from 15 to 21 days and in chick neonate from 1 to 21 days. Embryonic spinal cord showed higher ability than brain to incorporate acetoacetate into total lipids, although a sharp decrease was found at hatching. 3-Hydroxybutyrate incorpo...
journal_title:Neurochemical research
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doi:10.1007/BF02527668
更新日期:1996-01-01 00:00:00
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journal_title:Neurochemical research
pub_type: 杂志文章,评审
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journal_title:Neurochemical research
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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更新日期:2016-05-01 00:00:00
abstract::Metformin is the most frequently used drug for the treatment of type 2 diabetes in humans. However, only little is known about effects of metformin on brain metabolism. To investigate potential metabolic consequences of an exposure of brain cells to metformin, we incubated rat astrocyte-rich primary cultures with this...
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更新日期:2017-01-01 00:00:00
abstract::3-Nitropropionic acid (3-NP)-induced neurotoxicity can be used as a model for the genetic neurodegenerative disorder Huntington's disease (HD). A metabolic profiling strategy was adopted to explore the biochemical consequences of 3-NP administered to rats in specific brain regions. (1)H NMR spectroscopy was used to ch...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-008-9904-5
更新日期:2009-07-01 00:00:00
abstract::2,5-Hexanedione (2,5-HD) induces central-peripheral axonpathy characterized by the accumulation of 10-nm neurofilaments proximal to the nodes of Ranvier and a Wallerian-type degeneration. It has been postulated that neurofilament crosslinking may be involved in the production of this axonopathy. A potential initiating...
journal_title:Neurochemical research
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