Abstract：
:The interactions of S-nitrosoglutathione (GSNO) with the ionotropic glutamate receptors were studied on synaptic membranes isolated from the pig cerebral cortex. GSNO displaced the binding of [3H]glutamate, 3-[(R)-2-carboxypiperazin-4-yl] [3H]propyl-1-phosphonate ([3H]CPP), a competitive N-methyl-D-aspartate (NMDA) antagonist, and [3H]kainate, with IC50 values in the low micromolar range. It failed to displace (S)-5-fluoro-[3H]willardiine, a selective agonist of 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors. Reduced and oxidized glutathione were almost as effective as GSNO in glutamate and CPP binding. Of the three, GSNO was the most potent in kainate binding. They all stimulated [3H]dizocilpine binding in a concentration-dependent manner. This effect was additive to that of glycine and not mimicked by NO donors such as S-nitroso-N-acetylpenicillamine, 5-amino-3-morpholinyl-1,2,3-oxadiazolium chloride (SIN-1) and nitroglycerin. We assume that GSNO may act as an endogenous ligand at the NMDA and non-NMDA classes of glutamate receptors. In this manner it may facilitate NO transfer and target its delivery to specific sites in these receptors.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Hermann A,Varga V,Janáky R,Dohovics R,Saransaari P,Oja SSdoi
10.1023/a:1007626230278keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
1119-24issue
8eissn
0364-3190issn
1573-6903journal_volume
25pub_type
杂志文章abstract：:The effect of isoproterenol, norepinephrine, dopamine, and serotonin on the accumulation of adenosine 3',5'-monophosphate (cAMP) was studied in homogeneous neuronal cultures from 8-day chick embryo hemispheres. Among the catecholamines, isoproterenol had a more pronounced effect on the accumulation of cAMP. Norepineph...
journal_title：Neurochemical research
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更新日期：1984-02-01 00:00:00
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更新日期：2014-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
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更新日期：1992-12-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1007/BF00964728
更新日期：1983-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Neurochemical research
pub_type： 杂志文章
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更新日期：1980-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章
doi：10.1023/a:1027320113151
更新日期：1997-04-01 00:00:00
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journal_title：Neurochemical research
pub_type： 杂志文章,评审
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