Abstract:
:The frontal cortex, hippocampus, and cerebellum of the Fischer 344 rat were examined for an age-dependent change in neuronal and non-neuronal binding. Clonazepam and Ro5-6669 displaceable [3H]diazepam binding were used as indicators of [3H]diazepam binding on neuronal and non-neuronal membranes, respectively. In both the frontal cortex and the hippocampus, clonazepam displaceable [3H]diazepam binding in the senescent rat was significantly less than the young and mature rat. In the frontal cortex, Ro5-6669 did not significantly displace [3H]diazepam binding in any age group. The Ro5-6669 displaceable [3H]diazepam binding in the hippocampus was not altered with age. In the cerebellum clonazepam and Ro5-6669 displaceable binding in the old rat was significantly less and more, respectively, compared to the young rat.
journal_name
Neurochem Resjournal_title
Neurochemical researchauthors
Komiskey HL,MacFarlan MFdoi
10.1007/BF00964927subject
Has Abstractpub_date
1983-09-01 00:00:00pages
1135-41issue
9eissn
0364-3190issn
1573-6903journal_volume
8pub_type
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