Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus.

abstract：:Mitochondrially bound brain hexokinase is solubilized by anesthetics and this effect has been suggested to contribute to anesthesia. In the present investigation the influence of the metabolic inhibitor 2-deoxy-D-glucose (2-DOG) was studied. An isolated rat brain preparation was used to avoid the contribution of perip...

journal_title：Neurochemical research

authors： Krieglstein J,Sperling G,Stock R

更新日期：1982-06-01 00:00:00

abstract：:The overlapping distribution of opioid and cholecystokinin (CCK) peptides and their receptors (mu and delta opioid receptors; CCK-A and CCK-B receptors) in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides. Most of the phar...

journal_title：Neurochemical research

authors： Roques BP,Noble F

更新日期：1996-11-01 00:00:00

abstract：:The aim of the present study was to investigate possible membrane and genomic effects of corticosterone on the noradrenergic system of the rat brain. Corticosterone effects were studied in vivo by treating rats s.c. with 10 mg/kg corticosterone for 7 or 14 days. In the first two experiments corticosterone significantl...

journal_title：Neurochemical research

authors： de Villiers AS,Russell VA,Taljaard JJ

更新日期：1992-03-01 00:00:00

abstract：:An analytical method for the determination of saturated very long chain (VLC) fatty acids in the serum has been devised. Free fatty acids obtained after hydrolysis of total lipid extracts were converted into p-bromophenacyl esters. The derivatives were purified in two sequential steps by clean-up on C18 reversed-phase...

journal_title：Neurochemical research

authors： Alberghina M,Fiumara A,Pavone L,Giuffrida AM

更新日期：1984-12-01 00:00:00

abstract：:Cathepsin B (EC 3.4.22.1) was purified 746-fold with a 21% recovery from bovine brain by autolysis, fractional precipitation with acetone, carboxy-methyl-Sephadex chromatography, affinity chromatography on a cystamine containing column and gel filtration chromatography. The purified cathepsin B eluted on gel filtratio...

journal_title：Neurochemical research

authors： Bradley JD,Whitaker JN

更新日期：1986-06-01 00:00:00

abstract：:Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxa...

journal_title：Neurochemical research

authors： Wang XP,Ye P,Lv J,Zhou L,Qian ZY,Huang YJ,Mu ZH,Wang X,Liu XJ,Wan Q,Yang ZH,Wang F,Zou YY

更新日期：2019-04-01 00:00:00

abstract：:Abnormal myo-[2-3H]inositol incorporation into phosphatidylinositol has been found in phentolamine-treated synaptosomes that were isolated from the cerebral hemispheres of galactose toxic rats and incubated with [33P]Pi and myo-[2-3H] inositol. In galactose toxic rats phentolamine-stimulated myo-[2-3H]inositol labelin...

journal_title：Neurochemical research

authors： Berry G,Yandrasitz JR,Segal S

更新日期：1982-01-01 00:00:00

abstract：:In membranes of rat striatum, phorbol 12-myristate 13-acetate (PMA), a potent activator of Ca2+/phospholipid-dependent protein kinase, enhanced adenylate cyclase activity by counteracting the inhibition elicited by GTP. Exposure to pertussis toxin caused a similar alteration of the GTP-regulation of the enzyme activit...

journal_title：Neurochemical research

authors： Olianas MC,Onali P

更新日期：1990-11-01 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP(+)) or 6-hydroxydopamine (6-OHDA) caused a nuclear damage, the mitochondrial membrane permeability changes, leading to the cytochrome c release and caspase-3 activation, the formation of reactive oxygen species and the depletion of GSH in PC12 cells. Nicardipine (a calcium channel bloc...

journal_title：Neurochemical research

authors： Lee DH,Han YS,Han ES,Bang H,Lee CS

更新日期：2006-07-01 00:00:00

abstract：:Exposure to sevoflurane and other inhalational anesthetics can induce cognitive impairment in elderly patients. Studies have indicated that methylene blue (MB) has beneficial effects on multiple neurodegenerative diseases and the mechanism involves mitochondrial function preservation. However, whether MB can attenuate...

journal_title：Neurochemical research

authors： Zheng F,Fang P,Chang J,Chen M,Zhong Q,Chen T,Chen C,Zhang Z

更新日期：2020-04-01 00:00:00

abstract：:The phosphoinositide signal transduction system, and particularly, phospholipase Cbeta isozymes, are relevant in the etiopathogeny of human neuropsychiatric pathologies such as depression. Stimulation of phospholipase Cbeta activity by muscarinic receptors and G proteins was determined in crude and synaptosomal membra...

journal_title：Neurochemical research

authors： Garro MA,López de Jesús M,Ruíz de Azúa I,Callado LF,Meana JJ,Sallés J

更新日期：2004-07-01 00:00:00

abstract：:The potassium-stimulated release of acetylcholine, norepinephrine, serotonin, glutamate, and 4-aminobutyrate from superfused rat cortical slices was studied during hypoxia. A reduction in oxygen tensions from 603 +/- 6 to 22 +/- 2 mm Hg selectively altered the calcium-dependent efflux of these neurotransmitters, but d...

journal_title：Neurochemical research

authors： Hirsch JA,Gibson GE

更新日期：1984-08-01 00:00:00

abstract：:In this review properties of lipid acetyltransferase enzymes are outlined. The three activities of interest are lyso PAF acetyltransferase (acetyl CoA: 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase), AGP acetyltransferase (acetyl CoA: 1-alkyl sn-glycero-3-phosphate acetyltransferase) and a transacetylase activ...

journal_title：Neurochemical research

authors： Baker RR

更新日期：2000-05-01 00:00:00

abstract：:Adult rabbit brain contains the enzymatic machinery to convert deoxyuridine to deoxyuridine triphosphate (dUTP). Although dUTP as dUMP can be readily incorporated into DNA in place of thymidine monophosphate, we detected no (3H)dUMP in newly synthesized (3H)DNA in adult rabbit brain after the intraventricular injectio...

journal_title：Neurochemical research

authors： Spector R,Boose B

更新日期：1983-08-01 00:00:00

abstract：:Cholinesterase activities in rat forebrain, erythrocytes, and plasma were assessed after a single oral administration of metrifonate or dichlorvos. In 3-month-old rats, the dichlorvos (10 mg/kg p.o.)induced inhibition of cholinesterase reached its peak in brain after l5-45 min and after 10-30 min in erythrocytes and p...

journal_title：Neurochemical research

authors： Hinz V,Grewig S,Schmidt BH

更新日期：1996-03-01 00:00:00

abstract：:Using the replication-defective adenovirus vector, we overexpressed rat glia maturation factor (GMF) in primary astrocyte cultures derived from embryonic rat brains. Among the three isoforms of MAP kinase, there was a big increase in the phosphorylation of p38, as detected with Western blotting using the phosphospecif...

journal_title：Neurochemical research

authors： Zaheer A,Yorek MA,Lim R

更新日期：2001-12-01 00:00:00

abstract：:Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I pro...

journal_title：Neurochemical research

authors： Shen Y,Zhao H,Li P,Peng Y,Cui P,Miao F,Zhang Y,Zhang A,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Turmeric has been in use since ancient times as a condiment and due to its medicinal properties. Curcumin, the yellow colouring principle in turmeric, is polyphenolic and major active constituent. Besides anti-inflammatory, thrombolytic and anticarcinogenic activities, curcumin also possesses strong antioxidant proper...

journal_title：Neurochemical research

authors： Shukla PK,Khanna VK,Ali MM,Khan MY,Srimal RC

更新日期：2008-06-01 00:00:00

abstract：:Pre-eclampsia (PE) is a pregnancy complicated syndrome that affects multiple organs including the brain that continue post- delivery in both mother and the offspring. We evaluated the expression of oligodendrocytes in the brain of PE rat model through development as well as the cognitive changes and other behavioural ...

journal_title：Neurochemical research

authors： Ijomone OK,Shallie PD,Naicker T

更新日期：2020-04-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...

journal_title：Neurochemical research

authors： Li S,Wang D,Tian Y,Wei H,Zhou Z,Liu L,Wang D,Dong JF,Jiang R,Zhang J

更新日期：2015-07-01 00:00:00

abstract：:NMDA, the specific agonist of glutamate gated ion channels permeable to calcium, is implicated as a causal factor in the pathogenesis of several neurobiological disorders such as stroke, seizures, ischemia, and chronic neurodegenerative diseases. On the other hand, evidence on the roles of oxidative mechanisms involve...

journal_title：Neurochemical research

authors： Küçükkaya B,Haklar G,Yalçin AS

更新日期：1996-12-01 00:00:00

abstract：:Ménière's disease (MD) is characterized by the triad of fluctuating hearing loss, episodic vertigo and tinnitus, and by endolymphatic hydrops found on post-mortem examination. Increasing evidence suggests that oxidative stress is involved in the development of endolymphatic hydrops and that cellular damage and apoptot...

journal_title：Neurochemical research

authors： Calabrese V,Cornelius C,Maiolino L,Luca M,Chiaramonte R,Toscano MA,Serra A

更新日期：2010-12-01 00:00:00

abstract：:We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathi...

journal_title：Neurochemical research

authors： Tasset I,Drucker-Colín R,Peña J,Jimena I,Montilla P,Medina FJ,Túnez I

更新日期：2010-08-01 00:00:00

abstract：:Rats were long-term morphine-intoxicated by a fluid-diet model ensuring an equal nutrient intake in morphinized and control rats. Uptake of neurotransmitters and D-ala2-met5-enkephalinamide (Enk) was studied in the particulate fractions (obtained at 10,000 g) from well defined brain regions of long-term intoxicated an...

journal_title：Neurochemical research

authors： Rönnbäck L,Hansson E,Cupello A,Rapallino MV,Zeuchner J,Rosengren L

更新日期：1986-02-01 00:00:00

abstract：:Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope...

journal_title：Neurochemical research

authors： Elkon K,Weissbach H,Brot N

更新日期：1990-04-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. The spelling of the author Tommaso Ianniti was incorrect and has been corrected as Tommaso Iannitti. The original article has been corrected. ...

journal_title：Neurochemical research

authors： Monfil T,Vázquez Roque RA,Camacho-Abrego I,Tendilla-Beltran H,Iannitti T,Meneses-Morales I,Aguilar-Alonso P,Flores G,Morales-Medina JC

更新日期：2018-02-01 00:00:00

abstract：:A major part of the Ca-activated proteolytic activity in the soluble fraction from rabbit brain could be due to the activity of the neutral thiol-proteases calpain I and II. The activity of calpains exceeded that of the endogenous inhibitor, calpastatin, at all developmental stages studied. The level of calpains incre...

journal_title：Neurochemical research

authors： Blomgren K,Karlsson JO

更新日期：1989-11-01 00:00:00

abstract：:Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...

journal_title：Neurochemical research

authors： Sitges M,Aldana BI,Reed RC

更新日期：2016-06-01 00:00:00

abstract：:Levels of free amino acids were determined quantitatively in whole ocular tissues of the rat eye with aid of a sensitive amino acid analyzer. The tissues studied were the retina, vitreous, lens, iris-ciliary body, and cornea. The retina and lens contained a more concentrated free amino acid pool than other tissues. Th...

journal_title：Neurochemical research

authors： Heinämäki AA,Muhonen AS,Piha RS

更新日期：1986-04-01 00:00:00

abstract：:Abnormally high levels of iron are observed in the brain of patients suffering from neurodegenerative disorders. The mechanisms involved in iron accumulation in neurodegenerative disorders remain poorly understood. In the present study we investigated the effects of aging and neonatal iron overload on the mRNA express...

journal_title：Neurochemical research

authors： Dornelles AS,Garcia VA,de Lima MN,Vedana G,Alcalde LA,Bogo MR,Schröder N

更新日期：2010-04-01 00:00:00