Developmental changes of calpain and calpastatin in rabbit brain.

abstract：:The 7S NGF complex from the male mouse submaxillary gland consists of the alpha, gamma, and beta subunits in the ratio alpha 2 gamma 2 beta. The beta (NGF) subunit contains all the known biolocial activity of 7S NGF. The alpha and gamma subunits are both members of glandular kallikrein gene family, yet only gamma subu...

journal_title：Neurochemical research

authors： Burcham TS,Sim I,Bolin LM,Shooter EM

更新日期：1991-06-01 00:00:00

abstract：:The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to multiple forms of cellular stress. p53 expression is elevated in damaged neurons in acute models of injury such as ischemia and epilepsy and i...

journal_title：Neurochemical research

authors： Morrison RS,Kinoshita Y,Johnson MD,Guo W,Garden GA

更新日期：2003-01-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation,...

journal_title：Neurochemical research

authors： Wei N,Wei Y,Li B,Pang L

更新日期：2017-05-01 00:00:00

abstract：:A variety of naturally occurring amino acids, their isomers, and synthetic analogs were tested for their ability to inhibit uptake of [3H]glutamate into presynaptic vesicles from bovine cerebral cortex. Strongest inhibition (Ki < 1mM) was observed for trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and erythr...

journal_title：Neurochemical research

authors： Winter HC,Ueda T

更新日期：1993-01-01 00:00:00

abstract：:The changes in both the levels of some free amino acids and their metabolism in the rat brain during the first 24 hr of postnatal life were studied. The content of glutamic acid decreased for the first 2 hr; it remained at the lowest level for the next 4 hr, when it began to increase. The content of alanine decreased ...

journal_title：Neurochemical research

authors： Noguchi T,Nomura M,Tsukada Y

更新日期：1980-10-01 00:00:00

abstract：:GABAergic and cholinergic synaptosome populations were isolated by immunomagnetophoresis. Analysis of 8 amino acids showed that the GABAergic population was enriched in GABA (3 fold). The cholinergic population was enriched in citrulline (5 fold). CCK was found in both populations, but was enriched in the GABAergic. N...

journal_title：Neurochemical research

authors： Hughes PD,Foley P,Bradford HF,Ghatei M,Khandanian N,Bloom SR,Wu JY

更新日期：1993-04-01 00:00:00

abstract：:The Wistar-Kyoto (WKY) rat strain has been described as an animal model of depressive behavior that consumes significantly greater amounts of alcohol compared to the Wistar (WIS) rat strain. Since the mesolimbic dopamine (DA) type-2 (D2) receptors mediate reward-related behaviors, the present study measured the bindin...

journal_title：Neurochemical research

authors： Morganstern I,Tejani-Butt S

更新日期：2010-11-01 00:00:00

abstract：:Microglia, the resident immune cells of the CNS, are primary regulators of the neuroimmune response to injury. Type I interferons (IFNs), including the IFNαs and IFNβ, are key cytokines in the innate immune system. Their activity is implicated in the regulation of microglial function both during development and in res...

journal_title：Neurochemical research

authors： McDonough A,Lee RV,Weinstein JR

更新日期：2017-09-01 00:00:00

abstract：:2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) was phosphorylated in vivo, in brain slices and in a cell free system. Phosphoamino acid analysis of immunoprecipitated CNP labeled in vivo and in brain slices revealed phosphorylation of phosphoserine (94%) and phosphothreonine (5%) residues. Phosphorylation of CNP in...

journal_title：Neurochemical research

authors： Agrawal HC,Sprinkle TJ,Agrawal D

更新日期：1994-06-01 00:00:00

abstract：:Astrocytes occupy a strategic position in the brain where they can act as an interface between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This location is ideal for functioning as interoceptors, as they may sense changes in brain microenvironment and contribute to the adaptive homeostatic r...

journal_title：Neurochemical research

authors： Teschemacher AG,Gourine AV,Kasparov S

更新日期：2015-12-01 00:00:00

abstract：:Postmortem cerebral neocortical and hippocampal samples were taken from patients who died with dementia of the Alzheimer type (DAT) and individuals without diagnoses of neurological or psychiatric disease (control). Nicotinic binding was assayed with 20 nM [3H]acetylcholine [( 3H]ACh) in the presence of atropine, or w...

journal_title：Neurochemical research

authors： London ED,Ball MJ,Waller SB

更新日期：1989-08-01 00:00:00

abstract：:Hypoxia-induced oxidative stress is one of the major hallmark reasons underlying brain dysfunction. In the present manuscript, we have used CoCl2-induced hypoxic mice to investigate alterations in the activities of chief antioxidative stress enzymes- superoxide dismutase (SOD) and catalase (CAT) and expression of thei...

journal_title：Neurochemical research

authors： Rani A,Prasad S

更新日期：2014-09-01 00:00:00

abstract：:We tested the action of proline-rich peptide (PRP-1) and cobra venom Naja Naja Oxiana (NOX) on Deiters' nucleus neurons at 3rd, 15th and 35th days after unilateral labyrinthectomy (UL). Early and late tetanic, post-tetanic potentiation and depression of Deiters'neurons to bilateral high frequency stimulation of hypoth...

journal_title：Neurochemical research

authors： Galoyan AA,Khalaji N,Hambardzumyan LE,Manukyan LP,Meliksetyan IB,Chavushyan VA,Sarkisian VH,Sarkissian JS

更新日期：2010-11-01 00:00:00

abstract：:The regional distribution of 2-amino-4-phosphonobutyrate (APB)/chloride-insensitive L-[3H]glutamate binding sites in the rat central nervous system was compared with that of APB/chloride-sensitive and with sodium-dependent binding sites. The distribution of APB-sensitive and APB-insensitive sites was not correlated, b...

journal_title：Neurochemical research

authors： Larder AP,McLennan H

更新日期：1984-03-01 00:00:00

abstract：:Neuronal excitation leads to an increase of the extracellular K(+) concentration ([K(+)]o) in brain. This increase has at least two energy-consuming consequences: (1) a depolarization-mediated change in intracellular pH (pHi) in astrocytes due to depolarization-mediated increased activity of the acid-extruding Na(+)/b...

journal_title：Neurochemical research

authors： Song D,Man Y,Li B,Xu J,Hertz L,Peng L

更新日期：2013-11-01 00:00:00

abstract：:The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and G...

journal_title：Neurochemical research

authors： Battistin L,Varotto M,Berlese G,Roman G

更新日期：1984-02-01 00:00:00

abstract：:The influence of theophylline (2.5--100 mg/kg p.o.) on cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5'-guanosine monophosphate (cGMP) in brain of Sprague-Dawley rats (0.5--3.0 hr after administration of theophylline) was investigated. It was found that theophylline increases cAMP and cGMP levels when admi...

journal_title：Neurochemical research

authors： Stefanovich V

更新日期：1979-10-01 00:00:00

abstract：:Microdissection of selected regions of central nervous system (CNS) has provided the basis of modern chemoarchitectonics. Laser microdissection is a modern variant of the "Palkovits punch" technique and used together with gene array analysis has revolutionalized CNS molecular analysis. Here we describe the use of such...

journal_title：Neurochemical research

authors： Mutsuga N,Gainer H

更新日期：2006-02-01 00:00:00

abstract：:The ability of Sendai virosomes or Lipofectin to introduce an AAV vector into primary rat brain astroglial cultures was characterized. The pJDT95npy vector was constructed by inserting rat NPY cDNA downstream from the indigenous AAV p5, p19 and p40 promoters in pJDT95. Lipofectin-mediated transfection with pJDT95npy (...

journal_title：Neurochemical research

authors： de Fiebre CM,Wu P,Notabartolo D,Millard WJ,Meyer EM

更新日期：1994-06-01 00:00:00

abstract：:We have measured the postnatal development and GABA modulation of benzodiazepine receptors in neuronal membranes from vitamin B-6 deficient and normal rats. In rats fed vitamin B-6 adequate and deficient diets there were age-dependent changes in [3H]flunitrazepam binding site affinity and in the number of binding site...

journal_title：Neurochemical research

authors： Pilachowski J,Guilarte TR

更新日期：1993-12-01 00:00:00

abstract：:This review summarizes the recent research development on mammalian sialidase molecular cloning. Sialic acid-containing compounds are involved in several physiological processes, and sialidases, as glycohydrolytic enzymes that remove sialic acid residues, play a pivotal role as well. Sialidases hydrolyze the nonreduci...

journal_title：Neurochemical research

authors： Monti E,Preti A,Venerando B,Borsani G

更新日期：2002-08-01 00:00:00

abstract：:Hyperprolinemia type II (HPII) is an autosomal recessive disorder caused by the severe deficiency of enzyme delta1-pyrroline-5-carboxylic acid dehydrogenase leading to tissue accumulation of proline. Chronic administration of Pro led to significant reduction of cytosolic ALT activity of olfactory lobes (50.57%), cereb...

journal_title：Neurochemical research

authors： Shanti ND,Shashikumar KC,Desai PV

更新日期：2004-12-01 00:00:00

abstract：:The axonal transport of tRNA has been investigated in the chick optic system. Chicks were injected with [3H]uridine intraocularly or intracranially and the RNA of the retina, nerve complex, and tecta separated by polyacrylamide gel electrophoresis and then counted. The ratio of tRNA to rRNA specific activities increas...

journal_title：Neurochemical research

authors： Por S,Gunning PW,Jeffrey PL,Austin L

更新日期：1978-08-01 00:00:00

abstract：:Using a model of middle cerebral artery occlusion (MCAO), we have previously demonstrated that treadmill exercise promotes angiogenesis in the ischemic penumbra through caveolin-1/VEGF signaling pathways. However, the function of caveolin-1/VEGF signaling in neurogenesis after MCAO has not been determined. In this stu...

journal_title：Neurochemical research

authors： Zhao Y,Pang Q,Liu M,Pan J,Xiang B,Huang T,Tu F,Liu C,Chen X

更新日期：2017-02-01 00:00:00

abstract：:Amphiphile dependency, solubility in aqueous solutions, and sensitivity to proteolysis of acetylcholinesterase (AChE) and nonspecific cholinesterase (nsChE) in the rat superior cervical ganglion were studied and compared to properties of soluble plasma cholinesterases. Ganglion AChE shows strong amphiphile dependency:...

journal_title：Neurochemical research

authors： Klinar B,Kamarić L,Sketelj J,Brzin M

更新日期：1985-06-01 00:00:00

abstract：:Agonist occupancy of muscarinic cholinergic receptors in human SH-SY-5Y neuroblastoma cells elicited two kinetically distinct phases of phosphoinositide hydrolysis when monitored by either an increased mass of inositol 1,4,5-trisphosphate, or the accumulation of a total inositol phosphate fraction. Within 5s of the ad...

journal_title：Neurochemical research

authors： Fisher SK,Slowiejko DM,McEwen EL

更新日期：1994-05-01 00:00:00

abstract：:The effects of chronic pentobarbital (PB) treatment on the binding characteristics of [3H]flunitrazepam (FLU) in rat brain were examined. Saline or sodium PB (500 micrograms/10 microliters/hr) was infused into the lateral cerebral ventricles of rats for 6 days using osmotic pumps. Immediately before withdrawal, there ...

journal_title：Neurochemical research

authors： Miyaoka T,Kimura T,Saunders PA,Tseng YT,Ho IK

更新日期：1994-01-01 00:00:00

abstract：:Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine an...

journal_title：Neurochemical research

authors： Ferreira GK,Jeremias IC,Scaini G,Carvalho-Silva M,Gomes LM,Furlanetto CB,Morais MO,Schuck PF,Ferreira GC,Streck EL

更新日期：2013-08-01 00:00:00

abstract：:Berberine and palmatine exhibit a mild and competitive inhibition on bovine adrenal tyrosine hydroxylase (EC 1.14.16.2; TH). In this study, the inhibitory effects of protoberberine alkaloids (such as berberine, palmatine and coptisine) on dopamine biosynthesis in PC12 cells were investigated. Treatment with berberine ...

journal_title：Neurochemical research

authors： Shin JS,Kim EI,Kai M,Lee MK

更新日期：2000-03-01 00:00:00

abstract：:The labeling of RNA in young and adult rat brain has been studied by measuring in vitro (tissue slices incubation) the incorporation of labeled uridine into RNA of total tissue and of the various subcellular fractions purified from cerebral hemispheres of 1- and 10-month-old rats. Gel electrophoretic analysis of the n...

journal_title：Neurochemical research

authors： Serra I,Cupello A,Gadaleta MN,Viola M,Ragonese P,Giuffrida AM

更新日期：1983-04-01 00:00:00